Polynomial Wavelet Trees for Bidirectional Texture Functions

International audiencePolynomial Wavelet Tree is a new tool for accurate and efficient compression of BTFs. The key idea is to separate directional and spatial variations by projecting the spatial BTF domain (i.e., the light-dependent textures) onto a wavelet basis and to approximate these light-dependent wavelet coefficients with a polynomial function. Fitting wavelet coefficients instead of data themselves is a more efficient approximation compared to previous solutions since low frequency light transitions are smooth and higher frequency coefficients can be quantized with less importance. This wavelet projection and the light-dependent polynomial approximation is done for each view-point. Our solution is also designed for efficient high quality materials rendering on GPU

Trajectoires des travailleurs recevant un programme de retour au travail : étude exploratoire des discussions d’une équipe interdisciplinaire

Sujet : Cette étude exploratoire a pour objectif de décrire différents types de trajectoires de travailleurs présentant des troubles musculo-squelettiques pendant un programme de réadaptation. Les trajectoires sont tracées à partir des visions d’une équipe interdisciplinaire.Méthode : Le devis de recherche est une méthode de cas unique où l’unité d’analyse principale est une équipe interdisciplinaire. Cette équipe a discuté de la progression de 18 travailleurs, durant un programme de réadaptation. Les analyses des discussions ont été inspirées par la phénoménologie. Toutes les discussions de l’équipe ont été enregistrées et retranscrites. L’analyse de contenu a été effectuée par deux chercheurs. Résultats : Quatre types de trajectoires ont émergé : 1) trajectoires de retour au travail sans obstacle ; 2) trajectoires de retour au travail avec obstacles ; 3) trajectoires de non-retour au travail avec épisodes de progression et 4) trajectoires de non-retour au travail sans progression. Trois facteurs clefs ont émergé de ces analyses comme déterminant au processus de retour au travail : 1) la complaisance des travailleurs face au programme de réadaptation, 2) les différentes façons dont le travailleur aborde et vit la première exposition au travail et 3) la collaboration avec les différents partenaires. Les résultats de cette étude suggèrent aussi que l’absence de message unique entre les professionnels de la santé face au travailleur peut entraîner de la confusion et devenir un frein à la reprise des activités.Conclusions : Les résultats soulignent encore une fois la complexité pour les cliniciens de la prise en charge en réadaptation au travail de travailleurs en phase chronique. Cette intervention doit agir à la fois sur le travailleur et également sur les interactions entre les travailleurs et les différents partenaires concernés. Aussi, cette étude souligne le processus non linéaire de la réadaptation au travail pour des individus présentant des incapacités prolongées d’origine musculo-squelettique, tel que décrit par une équipe interdisciplinaire.Purpose : Based on the viewpoint of an interdisciplinary team, this exploratory study aimed to identify different types of trajectories followed by workers with musculoskeletal disorders and the factors contributing to them.Methods : The research design used a single-case study in which the main unit of analysis was an interdisciplinary work team. This team discussed eighteen workers’ progression during a work rehabilitation programme. Analytical methods were based on phenomenology. All team discussions were audiotaped and transcribed, and two researchers completed the content analysis.Results : Four types of trajectories emerged : (1) return-to-work trajectories without obstacles ; (2) return-to-work trajectories with obstacles ; (3) non-return-to-work trajectories with episodes of progression ; and (4) non-return-to-work trajectories without progression. Moreover, three outlines emerged from the data analysis : (1) the worker’s compliance with the programme ; (2) the way the worker coped with exposure to work ; and (3) stakeholder collaboration. The results of this study also suggested that the absence of a single consistent message among participating health professionals could create confusion for workers and pose a major impediment to the resumption of their activities.Conclusion : The results underscore, for clinicians, the complexity in managing this type of chronic work rehabilitation population, related to both the worker and the worker’s interactions with the stakeholders. Also, this study casts light on the non-linear work rehabilitation processes of individuals with prolonged disabilities of musculoskeletal origin, as described by an interdisciplinary team.Tema : Este estudio exploratorio se propone identificar diferentes tipos de trayectorias de trabajadores que presentan lesiones músculo-esqueléticas en el marco de un programa de readaptación. Las trayectorias se definen a partir de las visiones de un equipo interdisciplinar.Método : El método utilizado, llamado « devis de investigación » es un método basado en el estudio de casos y en el cual la unidad de análisis principal es un equipo interdisciplinar. En este caso, el equipo ha intercambiado opiniones acerca de la progresión de dieciocho trabajadores durante un programa de readaptación. El análisis de los intercambios ha seguido un enfoque fenomenológico. Todas las discusiones del equipo han sido grabadas y desgrabadas posteriormente. El análisis del contenido ha sido efectuado por dos investigadores.Resultados : Cuatro tipos de trayectorias han emergido : 1) trayectorias de reinsecion laboral sin obstaculos ; 2) Trayectorias de reinserción laboral con obstáculos ; 3) trayectorias sin reinserción laboral y con episodios de progresión ; y 4) trayectorias sin reinserción laboral y sin progresión. Tres factores clave han emergido de estos análisis en tanto determinates del proceso de reinserción laboral : 1) el hecho de que los trabajadores respeten el programa de readaptación, 2) las diferentes formas en las que el trabajador aborda y vive su primera exposición al trabajo, 3) la colaboracion con los diferentes compañeros de trabajo. Los resultados de este estudio sugieren tambien que la ausencia de unidad en los mensajes enviados por los profesionales de la salud al trabajador puede generar confusión y transformarse en un freno en el proceso de retorno a la actividad.Conclusiones : Los resultados obtenidos resaltan una vez más la complejidad que significa, desde un enfoque clínico, el hacerce cargo de la readaptación del trabajador en fase crónica. Esta intervención debe actuar a la vez sobre el trabajador y sobre las interacciones entre los trabajadores y las diferentes personas implicadas. Asimismo, este estudio subraya la no linealidad de la readaptación laboral para los individuos que presentan incapacidades prolongadas de origen musculoesquelético, tal como lo describe un equipo interdisciplinar

Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women123

Background: Whereas the negative effect of consuming trans fatty acids found in partially hydrogenated vegetable oils on cardiovascular disease (CVD) risk is well established, the effect of trans fatty acids from ruminant sources (rTFAs) on CVD risk factors has not yet been established, particularly among women

Reliability and Validity of Simplified Chinese Version of Roland-Morris Questionnaire in Evaluating Rural and Urban Patients with Low Back Pain

OBJECTIVE: The causes of low back pain in China and Western countries are extremely different. We attempted to analyze the risk factors of low back pain in urban and rural patients under the dual economy with the simplified Chinese version of Roland-Morris disability questionnaire (SC-RMDQ) to demonstrate that SC-RMDQ could evaluate patients with low back pain arising from different causes. METHODS: Roland-Morris disability questionnaire was translated into SCRMDQ according to international guidelines for questionnaire adaptation. In this study, causes of low back pain of 187 outpatients and inpatients (99 urban patients and 88 rural patients) were analyzed. All patients underwent simplified Chinese version of Roland-Morris disability questionnaire (SC-RMDQ), simplified Chinese Oswestry disability index (SCODI) and visual analogue scale (VAS). Reliability was tested using reproducibility (intraclass coefficient of correlation--ICC) and internal consistency (Cronbach's alpha). Validity was tested using Pearson correlation analysis. RESULTS: The leading causes for low back pain were sedentariness (38.4%) and vibration (18.1%) in urban patients and waist bending (48.9%) and spraining (25%) in rural patients. Although causes of low back pain in the two groups of population were completely different, SCRMDQ had high internal consistency (Cronbach's α value of 0.874 in urban patients and 0.883 in rural patients) and good reproducibility (ICC value of .952 in urban patients and 0.949 in rural patients, P<0.01). SCRMDQ also showed significant correlation with Simplified Chinese version of Oswestry disability index (SCODI) and visual analogue scale (VAS) in rural areas (SCRMDQ-SCODI r = 0.841; SCRMDQ-VAS: r = 0.685, P<0.01) and in urban areas (SCRMDQ-SCODI: r = 0.818, P<0.01; SCRMDQ-VAS: r = 0.666, P<0.01). CONCLUSIONS: Although causes of low back pain are completely different in rural and urban patients, SCRMDQ has a good reliability and validity, which is a reliable clinical method to evaluate disability of rural and urban patients

Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and study set-up

Background Following a 30-year development process, RTS,S/AS01E (GSK, Belgium) is the first malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Programme (MVIP) is coordinating the delivery of RTS,S/AS01E through routine national immunization programmes in areas of 3 countries in sub-Saharan Africa. The first doses were given in the participating MVIP areas in Malawi on 23 April, Ghana on 30 April, and Kenya on 13 September 2019. The countries participating in the MVIP have little or no baseline incidence data on rare diseases, some of which may be associated with immunization, a deficit that could compromise the interpretation of possible adverse events reported following the introduction of a new vaccine in the paediatric population. Further, effects of vaccination on malaria transmission, existing malaria control strategies, and possible vaccine-mediated selective pressure on Plasmodium falciparum variants, could also impact long-term malaria control. To address this data gap and as part of its post-approval commitments, GSK has developed a post-approval plan comprising of 4 complementary Phase IV studies that will evaluate safety, effectiveness and impact of RTS,S/AS01E through active participant follow-up in the context of its real-life implementation. Methods EPI-MAL-002 (NCT02374450) is a pre-implementation safety surveillance study that is establishing the background incidence rates of protocol-defined adverse events of special interest. EPI-MAL-003 (NCT03855995) is an identically designed post-implementation safety and vaccine impact study. EPI-MAL-005 (NCT02251704) is a cross-sectional pre- and post-implementation study to measure malaria transmission intensity and monitor the use of other malaria control interventions in the study areas, and EPI-MAL-010 (EUPAS42948) will evaluate the P. falciparum genetic diversity in the periods before and after vaccine implementation. Conclusion GSK’s post-approval plan has been designed to address important knowledge gaps in RTS,S/AS01E vaccine safety, effectiveness and impact. The studies are currently being conducted in the MVIP areas. Their implementation has provided opportunities and posed challenges linked to conducting large studies in regions where healthcare infrastructure is limited. The results from these studies will support ongoing evaluation of RTS,S/AS01E’s benefit-risk and inform decision-making for its potential wider implementation across sub-Saharan Africa

SAND, un protocole de chiffrement symétrique incompressible à structure simple

Nous avons développé un cryptosystème à clé symétrique hautement sécuritaire qui est basé sur un réseau de substitutions et de permutations. Il possède deux particularités importantes. Tout d'abord, il utilise de très grandes S-Boxes incompressibles dont la taille peut varier entre 256 Kb et 32 Gb bits d'entrée et qui sont générées aléatoirement. De plus, la phase de permutation est effectuée par un ensemble de fonctions linéaires choisies aléatoirement parmi toutes les fonctions linéaires possibles. Chaque fonction linéaire est appliquée sur tous les bits du bloc de message. Notre protocole possède donc une structure simple qui garantit l'absence de portes dérobées. Nous allons expliquer que notre cryptosystème résiste aux attaques actuellement connues telles que la cryptanalyse linéaire et la cryptanalyse différentielle. Il est également résistant à toute forme d'attaque basée sur un biais en faveur d'une fonction simple des S-Boxes.We developed a new symmetric-key algorithm that is highly secure. Our algorithm is SPN-like but with two main particularities. First of all, we use very large random incompressible s-boxes. The input size of our s-boxes vary between 256 Kb and 32 Gb.Secondly, for the permutation part of the algorithm, we use a set of random linear functions chosen uniformly and randomly between every possible fonctions. The input of these functions is all the bits of the block of messages to encode. Our system has a very simple structure that guarantees that there are no trap doors in it. We will explain how our algorithm is resistant to the known attacks, such as linear and differential cryptanalysis. It is also resistant to any attack based on a bias of the s-boxes to a simple function

Positive Bioluminescence Imaging of MicroRNA Expression in Small Animal Models Using an Engineered Genetic-Switch Expression System, RILES.

International audienceMicroRNAs (miRNAs) are a class of small, noncoding RNAs which regulate gene expression by directing their target mRNA for degradation or translational repression. Since their discovery in the early 1990s, miRNAs have emerged as key components in the posttranscriptional regulation of gene networks, shaping many biological processes from development, morphogenesis, differentiation, proliferation and apoptosis. Although understanding of the molecular basis of miRNA biology is improving, methods to monitor the dynamic and the spatiotemporal aspects of miRNA expression under physiopathological conditions are required. However, monitoring of miRNAs is difficult due to their small size, low abundance, high degree of sequence similarity, and their dynamic expression pattern which is subjected to tight transcriptional and post-transcriptional controls. Recently, we developed a miRNA monitoring system called RILES, standing for RNAi-inducible expression system, which relies on an engineered regulatable expression system, to switch on the expression of the luciferase gene when the targeted miRNA is expressed in cells. We demonstrated that RILES is a specific, sensitive, and robust method to determine the fine-tuning of miRNA expression during the development of an experimental pathological process in mice. Because RILES offers the possibility for longitudinal studies on individual subjects, sharper insights into miRNA regulation can be generated, with applications in physiology, pathophysiology and development of RNAi-based therapies. This chapter describes methods and protocols to monitor the expression of myomiR-206, -1, and -133 in the tibialis anterior muscle of mice. These protocols can be used and adapted to monitor the expression of other miRNAs in other biological processes

METHOD FOR REPRESENTING A MATERIAL

Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).The invention relates to a method for representing a material by approximating a modelling origin function of the interaction between the light emitted by a light source and the material, wherein said function is defined by a texture representing pixels, viewpoints and light directions, said method comprising: for each viewpoint, steps for the polynomial approximation of the origin modelling function and for the geometrical approximation of a remainder resulting from the difference between the origin modelling function and the polynomial approximation of said function; and astep of simplifying the results obtained after the two approximations by decomposition into wavelet packets.L'invention concerne un procédé de représentation d'un matériau par approximation d'une fonction d'origine de modélisation de l'interaction de la lumière émise par une source de lumière et le matériau, laquelle fonction est définie par une texture représentant des pixels, des points de vue et des directions de la lumière, lequel procédé comporte : - par point de vue, des étapes d'approximation polynomiale de la fonction de modélisation d'origine et d'approximation géométrique d'un résidu résultant de la différence entre la fonction de modélisation d'origine et l'approximation polynomiale de cette fonction; une étape de simplification par décomposition en paquets d'ondelettes des résultats obtenus à l'issue des deux approximations