Confinement interaction in nonlinear generalizations of the Wick-Cutkosky model

We consider nonlinear-mediating-field generalizations of the Wick-Cutkosky model. Using an iterative approach and eliminating the mediating field by means of the covariant Green function we arrive at a Lagrangian density containing many-point time-nonlocal interaction terms. In low-order approximations of $\phi^3{+}\phi^4$ theory we obtain the usual two-current interaction as well as a three-current interaction of a confining type. The same result is obtained without approximation for a version of the dipole model. The transition to the Hamiltonian formalism and subsequent canonical quantization is performed with time non-locality taken into account approximately. A relativistic three-particle wave equation is derived variationally by using a three-particle Fock space trial state. The non-relativistic limit of this equation is obtained and its properties are analyzed and discussed.Comment: 15 pages, 1 figure, LaTe

Screening for Color Vision Deficiency in Health Science Students

Purpose: Various professions require employees to be able to detect different shades of color accurately when visually reading test results with colorimetric end points. To prepare health science students to better meet this requirement, a screening test for color vision deficiency (CVD) was administered to detect any major or minor errors as part of the undergraduate student experience. Method: Screening for color vision deficiency was administered using the Farnsworth D-15 Color Vision Test. Students completed the test and their results were scored and interpreted at the time of completion. Results: Students (n=85) from nine different health science programs completed the Farnsworth D-15 Color Vision Test. Ages of the participants ranged from 18-63 years with 70% of the participants in the age range of 18-23 years. Seventy-one percent of the participants identified as female, 28% identified as males, and 1% identified as non-binary. Two students (one female and one male) had a minor error resulting in a crossover within the test circle on the Gulden test score sheet. There were no major errors identified in the 85 participants. Conclusion: While two minor errors were detected in this population, this data is not consistent with other CVD studies. This most likely is due to screening predominately female students, and/or the amount of time allotted for each individual test to be completed. Future studies will include expanding the participant numbers, with a focus on testing more male participants, limiting the number of minutes to complete the screening process, and collecting additional demographic data

Infusing a Course-Based Undergraduate Research Experience (CURE) into an Allied Health Curriculum

Purpose: Infusion of a course-based undergraduate research experience (CURE) into an existing research design course in an applied science curriculum allowed medical laboratory science students (n=22) to each be a contributing team member in a hand’s-on research experience, where most of the work was completed during the class time on campus. This design allowed for equal access, an equitable experience, and inclusion of all students enrolled in the course. Methods: Students and instructors worked together to develop a research question. The group agreed that the research question would be to determine the number of environmental specimens that were positive for mycobacteria species in residential plumbing specimens from different faucets and showerheads within residences in local areas. Before the actual collection of specimens, students reviewed the literature and completed more traditional modules in research ethics and Collaborative Institutional Training Initiative (CITI) training. Once that was completed, students designed and assembled the collection kits, collected and processed the specimens, and reported their results. Results: Students completed most tasks during the designated class time, and those tasks that had to be completed outside of class were not overwhelming for the students either in time or effort. The students’ reflections as the human subjects in this CURE indicated that 1) 90% of the students agreed they had a better understanding of the Institutional Review Board (IRB) process, 2) 100% of the students agreed the collection process was easily completed, 3) 100% of the students agreed the specimen testing was easily completed and interpreted, and 4) 100% of the students agreed the required parameters of a CURE were met. Conclusion: A CURE can be infused successfully into an applied science course allowing every student to become a contributing member of the research team

Variational Derivation of Relativistic Fermion-Antifermion Wave Equations in QED

We present a variational method for deriving relativistic two-fermion wave equations in a Hamiltonian formulation of QED. A reformulation of QED is performed, in which covariant Green functions are used to solve for the electromagnetic field in terms of the fermion fields. The resulting modified Hamiltonian contains the photon propagator directly. The reformulation permits one to use a simple Fock-space variational trial state to derive relativistic fermion-antifermion wave equations from the corresponding quantum field theory. We verify that the energy eigenvalues obtained from the wave equation agree with known results for positronium.Comment: 25 pages, accepted in Journal of Mathematical Physics (2004

Bound-State Variational Wave Equation For Fermion Systems In QED

We present a formulation of the Hamiltonian variational method for QED which enables the derivation of relativistic few-fermion wave equation that can account, at least in principle, for interactions to any order of the coupling constant. We derive a relativistic two-fermion wave equation using this approach. The interaction kernel of the equation is shown to be the generalized invariant M-matrix including all orders of Feynman diagrams. The result is obtained rigorously from the underlying QFT for arbitrary mass ratio of the two fermions. Our approach is based on three key points: a reformulation of QED, the variational method, and adiabatic hypothesis. As an application we calculate the one-loop contribution of radiative corrections to the two-fermion binding energy for singlet states with arbitrary principal quantum number $n$, and $l =J=0$. Our calculations are carried out in the explicitly covariant Feynman gauge.Comment: 26 page

Impact of flipper-banding on breeding success of African penguins Spheniscus demersus at Robben Island: comparisons among silicone rubber bands, stainless-steel bands and no bands

From 2001 to 2006, two new designs of flipper bands made from silicone rubbers were tested on African penguins Spheniscus demersus at 365 nests on Robben Island, South Africa. We compared, over six years, the breeding success, from hatching to fledging, of three different groups of penguins: those with rubber bands (117 nests), with conventional stainless-steel bands (103 nests) and without bands (145 nests). There were no significant differences in breeding success between the three groups, suggesting that neither the currently used steel bands, nor either of the new rubber-band designs, were harmful during the seasons investigated. The rubber bands caused less wear of feathers and less drag on a model penguin than the steel bands. In captivity, the behaviours of African penguins fitted with rubber bands were not noticeably different to those of unbanded birds

Bayesian inference reveals positive but subtle effects of experimental fishery closures on marine predator demographics

Global forage-fish landings are increasing, with potentially grave consequences for marine ecosystems. Predators of forage fish may be influenced by this harvest, but the nature of these effects is contentious. Experimental fishery manipulations offer the best solution to quantify population-level impacts, but are rare. We used Bayesian inference to examine changes in chick survival, body condition and population growth rate of endangered African penguins Spheniscus demersus in response to 8 years of alternating time–area closures around two pairs of colonies. Our results demonstrate that fishing closures improved chick survival and condition, after controlling for changing prey availability. However, this effect was inconsistent across sites and years, highlighting the difficultly of assessing management interventions in marine ecosystems. Nevertheless, modelled increases in population growth rates exceeded 1% at one colony; i.e. the threshold considered biologically meaningful by fisheries management in South Africa. Fishing closures evidently can improve the population trend of a forage-fish-dependent predator—we therefore recommend they continue in South Africa and support their application elsewhere. However, detecting demographic gains for mobile marine predators from small no-take zones requires experimental time frames and scales that will often exceed those desired by decision makers

Comparing open and minimally invasive surgical procedures for oesophagectomy in the treatment of cancer: the ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open) feasibility study and pilot trial

Localised oesophageal cancer can be curatively treated with surgery (oesophagectomy) but the procedure is complex with a risk of complications, negative effects on quality of life and a recovery period of 6-9 months. Minimal-access surgery may accelerate recovery.The ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open) study aimed to establish the feasibility of, and methodology for, a definitive trial comparing minimally invasive and open surgery for oesophagectomy. Objectives were to quantify the number of eligible patients in a pilot trial; develop surgical manuals as the basis for quality assurance; standardise pathological processing; establish a method to blind patients to their allocation in the first week post surgery; identify measures of postsurgical outcome of importance to patients and clinicians; and establish the main cost differences between the surgical approaches.Pilot parallel three-arm randomised controlled trial nested within feasibility work.Two UK NHS departments of upper gastrointestinal surgery.Patients aged ≥ 18 years with histopathological evidence of oesophageal or oesophagogastric junctional adenocarcinoma, squamous cell cancer or high-grade dysplasia, referred for oesophagectomy or oesophagectomy following neoadjuvant chemo(radio)therapy.Oesophagectomy, with patients randomised to open surgery, a hybrid open chest and minimally invasive abdomen or totally minimally invasive access.The primary outcome measure for the pilot trial was the number of patients recruited per month, with the main trial considered feasible if at least 2.5 patients per month were recruited.During 21 months of recruitment, 263 patients were assessed for eligibility; of these, 135 (51%) were found to be eligible and 104 (77%) agreed to participate, an average of five patients per month. In total, 41 patients were allocated to open surgery, 43 to the hybrid procedure and 20 to totally minimally invasive surgery. Recruitment is continuing, allowing a seamless transition into the definitive trial. Consequently, the database is unlocked at the time of writing and data presented here are for patients recruited by 31 August 2014. Random allocation achieved a good balance between the arms of the study, which, as a high proportion of patients underwent their allocated surgery (69/79, 87%), ensured a fair comparison between the interventions. Dressing patients with large bandages, covering all possible incisions, was successful in keeping patients blind while pain was assessed during the first week post surgery. Postsurgical length of stay and risk of adverse events were within the typical range for this group of patients, with one death occurring within 30 days among 76 patients. There were good completion rates for the assessment of pain at 6 days post surgery (88%) and of the patient-reported outcomes at 6 weeks post randomisation (74%).Rapid recruitment to the pilot trial and the successful refinement of methodology indicated the feasibility of a definitive trial comparing different approaches to oesophagectomy. Although we have shown a full trial of open compared with minimally invasive oesophagectomy to be feasible, this is necessarily based on our findings from the two clinical centres that we could include in this small preliminary study.Current Controlled Trials ISRCTN59036820.This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 20, No. 48. See the NIHR Journals Library website for further project information

Hole-mediated photoredox catalysis: Tris(: P-substituted)biarylaminium radical cations as tunable, precomplexing and potent photooxidants

As a combination of visible light photoredox catalysis and synthetic organic electrochemistry, electrochemically-mediated photoredox catalysis emerged as a powerful synthetic technique in recent years, overcoming fundamental limitations of electrochemistry and photoredox catalysis in the single electron transfer activation of small organic molecules. Herein we report a tunable class of electroactivated photoredox catalyst, tri(para-substituted)biarylamines, that become superoxidants in their photoexcited states even able to oxidize molecules beyond the solvent window limits of cyclic voltammetry (such as polyfluorobenzene and trifluorotoluene). Furthermore, we demonstrate that precomplexation not only permits the excited state photochemistry of tris(para-substituted)biarylaminium cations to overcome picosecond lifetime, but enables and rationalizes the surprising photochemistry of their higher-order doublet (Dn) excited states, unlocking extremely high oxidative potentials (up to a record-breaking ∼+4.4 V vs. SCE). This journal i