65 research outputs found
Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined with γ-rays at high dose rate (0·5 Gy/min), and with -particles at high (0·2 Gy/min) and at low dose rates (0·83-2·5 mGy/min) in the C3H 10T1/2 cell system.
α-particles were substantially more effective than γ-rays, both for cell inactivation and for neoplastic transformation at high and low dose rates. The relative biological effectiveness (RBE) for cell inactivation and for neoplastic transformation was of similar magnitude, and ranged from about 3 at an -particle dose of 2 Gy to values of the order of 10 at 0·25 Gy. In contrast to the experiments of Hill et al. (1984) with fission neutrons, no increased transformation frequencies were observed when the -particle dose was protracted over several hours
Radiosensitization by bromodeoxyuridine and hyperthermia: analysis of linear and quadratic parameters of radiation survival curves of two human tumor cell lines
Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death
Parameters of linear-quadratic radiation dose-effect relationships: dependence on LET and mechanisms of reproductive cell death
Honderd jaar radiologie in Nederland, IX : klinische radiobiologie
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Effects of different ionizing radiations on human cells in tissue culture; I. Irradiation techniques and dosimetry
Cell kinetic model of tumour growth and regression for a rhabdomyosarcoma in the rat: Undisturbed growth and radiation response to large single doses
Effectiveness of combined treatments of various types of transplantable rat tumour with ionizing radiation and drugs
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