814 research outputs found
Recursive Contracts
We model career design as a recursive contract design problem in an overlapping generations firm. Agents live two periods. In period 1 they may be hired as employees, paid a wage, and produce output. In period 2 they may be promoted to become joint owners (partners) of the firm, producing no output directly, but setting the rules and receiving the residual income. Professional partnerships, such as the traditional law firm, are often organized like this. Employees are motivated not only by the wage but by the possibility of promotion to the partnership, and the opportunity to set the rules in the next period; the reward structure is thus recursive. The contracts that emerge in this environment are always inefficient. In many circumstances the inefficiency takes the form of “rat-race” contracts that specify very low wages and an inefficiently high level of effort. This conclusion seems to be robust to a range of variations in the environment.recursive contracts, mechanism design, overlapping generations,rat-race
Rat Races and Glass Ceilings: Career Paths in Organizations.
In an ongoing organization, such as a large law parternship firm, employees are motivated not only by current rewards but also by the prospect of promotion, and the opportunity to influence policy and make the rules in the future. This leads to a dynamic programming problem in contract design. We model career design in such a firm as a recursive mechanism design problem in an overlapping generations environment.CONTRACTS ; GENERATIONS ; COSTS
Characterisation of the sarcomeric myosin heavy chain multigene family in the laboratory guinea pig
BACKGROUND:Several chronic conditions leading to skeletal muscle dysfunction are known to be associated with changes in the expression of myosin heavy chain (MHC) isoforms at both the mRNA and protein level. Many of these conditions are modelled, pre-clinically, in the guinea pig due to similar disease onset and progression to the human condition, and their generally well-characterised anatomy. MHC composition is amenable to determination by protein and mRNA based methodologies, the latter quantifying the expression of MHC isoform-specific gene transcripts allowing the detection of earlier, and more subtle changes. As such, the MHC mRNAs, and specific oligonucleotide primers of all common laboratory species have been available for some time. However, due to incomplete genomic annotation, assessment of guinea pig MHC mRNA expression has not been previously possible, precluding the full characterisation of early changes in skeletal muscle in response to disease and disease modulation.The purpose of this study was to characterise the multigenic structure of the sarcomeric MHC family in the guinea pig, and to design and validate specific oligonucleotide primers to enable the assessment of the predominant adult-muscle associated MHC mRNAs in relevant disease models.RESULTS:Using a combination of ligase-mediated rapid amplification of 5' and 3' cDNA ends (RACE) and bioinformatics, mRNAs to the four main skeletal-muscle isoforms of MHC were determined. Specific oligonucleotide primers were designed, and following verification of their specificity, found to successfully determine the expression of each MHC mRNA independently.CONCLUSIONS:Because of their utilisation in the in vivo modelling of disease, there is a requirement to develop molecular methods that accurately differentiate the different MHC mRNAs in the guinea pig to enable rapid profiling of muscle composition in appropriate disease models. The methods developed here are suitable for the characterisation of muscle MHC expression at the molecular level from animal tissue samples and biopsy material. The publication of these specific oligonucleotide primers for the guinea pig MHC variants will enable researchers to rapidly and accurately quantify acute changes in MHC mRNA expression in either developmental or in guinea pig disease models where a marker of altered skeletal muscle function is required
Dissociative attachment in HCl, DCl, and F2
Resonant scattering models, using nonlocal decay widths, are developed for dissociative attachment of slow electrons to diatomic molecules. Cross sections are obtained for HCl and DCl in several initial rotational and vibrational states, and the dependence of the average attachment cross section upon the rotational and vibrational temperature is examined. For F_2 the cross section for ground state molecules agrees well with experiment above 0.2 eV but shows no zero energy peak. The attachment cross section is higher for vibrationally excited molecules, but the enhancement is much less than that found in H_2 and HCl
Engineering a static verification tool for GPU kernels
We report on practical experiences over the last 2.5 years related to the engineering of GPUVerify, a static verification tool for OpenCL and CUDA GPU kernels, plotting the progress of GPUVerify from a prototype to a fully functional and relatively efficient analysis tool. Our hope is that this experience report will serve the verification community by helping to inform future tooling efforts. © 2014 Springer International Publishing
A predictive phenomenological tool at small Bjorken-x
We present the results from global fits of inclusive DIS experimental data
using the Balitsky-Kovchegov equation with running coupling.Comment: 5 pages, 2 figures, prepared for the Proceedings of 'Hot Quarks 2010
Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis.
Coordination when there are restricted and unrestricted options
One might expect that, in pure coordination games, coordination would become less frequent as the number of options increases. Contrary to this expectation, we report an experiment which found more frequent coordination when the option set was unrestricted than when it was restricted. To try to explain this result, we develop a method for eliciting the general rules that subjects use to identify salient options in restricted and unrestricted sets. We find that each such rule, if used by all subjects, would generate greater coordination in restricted sets. However, subjects tend to apply different rules to restricted and unrestricted sets
Managed Aquifer Recharge in the Poverty Bay Flats
In 2012 a report was commissioned by the Gisborne District Council (GDC) to examine groundwater resources in the Poverty Bay flats. This report found that groundwater elevations within the Makauri Gravel aquifer (the aquifer subject to the greatest groundwater abstractions), were declining at statistically significant rates, probably due to groundwater abstractions (White et al., 2012). As a result, the GDC is investigating whether managed aquifer recharge (MAR) can be used to help achieve the sustainable management of groundwater resources within the Poverty Bay flats. MAR is “the purposeful recharge of water to aquifers for subsequent recovery or environmental benefit” (Dillon et al., 2013, p. 2). Though MAR is uncommon in New Zealand, increasing pressures on groundwater may change this. GDC is investigating two different methods of MAR, well-injection (in conjunction with Golder Associates), and infiltration basins, which is the focus of this study
The potential of decision support systems to improve risk assessment for pollen beetle management in winter oilseed rape
BACKGROUNDThe reliance on and extensive use of pyrethroid insecticides have led to pyrethroid resistance in pollen beetle (Meligethes aeneus). Widespread adoption of best practice in pollen beetle management is therefore needed. Decision support systems (DSSs) that identify the risk period(s) for pest migration can help to target monitoring and control efforts, but they must be accurate and labour efficient to gain the support of growers. Weather data and the phenology of pollen beetles in 44 winter oilseed rape crops across England over 4 years were used to compare the performance of two risk management tools: the DSS proPlant expert, which predicts migration risk according to a phenological model and local weather data, and rule-based advice', which depends on crop growth stage and a temperature threshold. RESULTSBoth risk management tools were effective in prompting monitoring that would detect breaches of various control thresholds. However, the DSS more accurately predicted migration start and advised significantly fewer days of migration risk, consultation days and monitoring than did rule-based advice. CONCLUSIONThe proPlant expert DSS reliably models pollen beetle phenology. Use of such a DSS can focus monitoring effort to when it is most needed, facilitate the practical use of thresholds and help to prevent unnecessary insecticide applications and the development of insecticide resistance. (c) 2015 Rothamsted Research Ltd. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry
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