Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review

BACKGROUND: Clinical trials suggest that cyclo-oxygenase-2 specific inhibitors (coxibs) are an effective treatment for acute postoperative pain. The aims of this systematic review were to examine the evidence for oral valdecoxib and injected parecoxib, and quantify efficacy and adverse effects. METHODS: Information from randomized, double-blind studies in acute postoperative pain was sought. The area under the pain relief versus time curve over four to six hours was dichotomized using validated equations to derive the proportion of patients with treatment and placebo with at least 50% pain relief over four to six hours and calculate the number-needed-to-treat (NNT). Information on duration of analgesia and adverse events was also collected. RESULTS: The NNT for one patient to experience at least 50% relief over six hours following a single oral dose of valdecoxib 20 mg and 40 mg was 1.7 (1.4 to 2.0) and 1.6 (1.4 to 1.8) respectively. The NNT for one patient to have at least 50% relief over four to six hours with parecoxib 20 mg IV and 40 mg IV was 3.0 (2.3 to 4.1) and 2.3 (2.0 to 2.6) respectively. Mean time to remedication (weighted by trial size) was >24 hours with valdecoxib 40 mg, 8.7 hours with parecoxib 40 mg IV and 1.7 to 1.8 hours with placebo. There were no statistical differences between treatment and placebo for any adverse effect. CONCLUSION: Both oral valdecoxib and injected parecoxib are effective treatments for acute postoperative pain

5-dimensional contact SO(3)-manifolds and Dehn twists

In this paper the 5-dimensional contact SO(3)-manifolds are classified up to equivariant contactomorphisms. The construction of such manifolds with singular orbits requires the use of generalized Dehn twists. We show as an application that all simply connected 5-manifoldswith singular orbits are realized by a Brieskorn manifold with exponents (k,2,2,2). The standard contact structure on such a manifold gives right-handed Dehn twists, and a second contact structure defined in the article gives left-handed twists.Comment: 16 pages, 1 figure; simplification of arguments by restricting classification to coorientation preserving contactomorphism

Stellar science from a blue wavelength range - A possible design for the blue arm of 4MOST

From stellar spectra, a variety of physical properties of stars can be derived. In particular, the chemical composition of stellar atmospheres can be inferred from absorption line analyses. These provide key information on large scales, such as the formation of our Galaxy, down to the small-scale nucleosynthesis processes that take place in stars and supernovae. By extending the observed wavelength range toward bluer wavelengths, we optimize such studies to also include critical absorption lines in metal-poor stars, and allow for studies of heavy elements (Z>38) whose formation processes remain poorly constrained. In this context, spectrographs optimized for observing blue wavelength ranges are essential, since many absorption lines at redder wavelengths are too weak to be detected in metal-poor stars. This means that some elements cannot be studied in the visual-redder regions, and important scientific tracers and science cases are lost. The present era of large public surveys will target millions of stars. Here we describe the requirements driving the design of the forthcoming survey instrument 4MOST, a multi-object spectrograph commissioned for the ESO VISTA 4m-telescope. We focus here on high-density, wide-area survey of stars and the science that can be achieved with high-resolution stellar spectroscopy. Scientific and technical requirements that governed the design are described along with a thorough line blending analysis. For the high-resolution spectrograph, we find that a sampling of >2.5 (pixels per resolving element), spectral resolution of 18000 or higher, and a wavelength range covering 393-436 nm, is the most well-balanced solution for the instrument. A spectrograph with these characteristics will enable accurate abundance analysis (+/-0.1 dex) in the blue and allow us to confront the outlined scientific questions. (abridged)Comment: 14 pages, 8 figures, accepted for publication in A

Evolution of optically faint AGN from COMBO-17 and GEMS

We have mapped the AGN luminosity function and its evolution between z=1 and z=5 down to apparent magnitudes of $R<24$. Within the GEMS project we have analysed HST-ACS images of many AGN in the Extended Chandra Deep Field South, enabling us to assess the evolution of AGN host galaxy properties with cosmic time.Comment: to appear in proceedings 'Multiwavelength AGN Surveys', Cozumel 200

Cosmological weak lensing with the HST GEMS survey

We present our cosmic shear analysis of GEMS, one of the largest wide-field surveys ever undertaken by the Hubble Space Telescope. Imaged with the Advanced Camera for Surveys (ACS), GEMS spans 795 square arcmin in the Chandra Deep Field South. We detect weak lensing by large-scale structure in high resolution F606W GEMS data from ~60 resolved galaxies per square arcminute. We measure the two-point shear correlation function, the top-hat shear variance and the shear power spectrum, performing an E/B mode decomposition for each statistic. We show that we are not limited by systematic errors and use our results to place joint constraints on the matter density parameter Omega_m and the amplitude of the matter power spectrum sigma_8. We find sigma_8(Omega_m/0.3)^{0.65}=0.68 +/- 0.13 where the 1sigma error includes both our uncertainty on the median redshift of the survey and sampling variance. Removing image and point spread function (PSF) distortions are crucial to all weak lensing analyses. We therefore include a thorough discussion on the degree of ACS PSF distortion and anisotropy which we characterise directly from GEMS data. Consecutively imaged over 20 days, GEMS data also allows us to investigate PSF instability over time. We find that, even in the relatively short GEMS observing period, the ACS PSF ellipticity varies at the level of a few percent which we account for with a semi-time dependent PSF model. Our correction for the temporal and spatial variability of the PSF is shown to be successful through a series of diagnostic tests.Comment: 17 pages, 16 figures. Version accepted by MNRA

GEMS: Galaxy fitting catalogues and testing parametric galaxy fitting codes

In the context of measuring structure and morphology of intermediate redshift galaxies with recent HST/ACS surveys, we tune, test, and compare two widely used fitting codes (GALFIT and GIM2D) for fitting single-component Sersic models to the light profiles of both simulated and real galaxy data. We find that fitting accuracy depends sensitively on galaxy profile shape. Exponential disks are well fit with Sersic models and have small measurement errors, whereas fits to de Vaucouleurs profiles show larger uncertainties owing to the large amount of light at large radii. We find that both codes provide reliable fits and little systematic error, when the effective surface brightness is above that of the sky. Moreover, both codes return errors that significantly underestimate the true fitting uncertainties, which are best estimated with simulations. We find that GIM2D suffers significant systematic errors for spheroids with close companions owing to the difficulty of effectively masking out neighboring galaxy light; there appears to be no work around to this important systematic in GIM2D's current implementation. While this crowding error affects only a small fraction of galaxies in GEMS, it must be accounted for in the analysis of deeper cosmological images or of more crowded fields with GIM2D. In contrast, GALFIT results are robust to the presence of neighbors because it can simultaneously fit the profiles of multiple companions thereby deblending their effect on the fit to the galaxy of interest. We find GALFIT's robustness to nearby companions and factor of >~20 faster runtime speed are important advantages over GIM2D for analyzing large HST/ACS datasets. Finally we include our final catalog of fit results for all 41,495 objects detected in GEMS.Comment: Accepted for publication in ApJS October 2007, v172n2; 25 pages, 16 Figures, 9 Tables; for hi-resolution version, see http://www.mpia.de/homes/bhaeussl/galaxy_fitting.pdf. For results, catalogues and files for code-testing, see http://www.mpia.de/GEMS/fitting_paper.htm

Exploring the Impact of Galaxy Interactions over Seven Billion Years with CAS

We explore galaxy assembly over the last seven billion years by characterizing "normal" galaxies along the Hubble sequence, against strongly disturbed merging/interacting galaxies with the widely used CAS system of concentration (C), asymmetry (A), and 'clumpiness' (S) parameters, as well as visual classification. We analyze Hubble Space Telescope (HST) ACS images of ~4000 intermediate and high mass (> 10^9 solar masses) galaxies from the GEMS survey, one of the largest HST surveys conducted to date in two filters. We explore the effectiveness of the CAS criteria [A>S and A>~0.35] in separating normal and strongly disturbed galaxies at different redshifts, and quantify the recovery and contamination rate. We also compare the average star formation rate and the cosmic star formation rate density as a function of redshift between normal and interacting systems identified by CAS.Comment: ASP conference proceedings of 2007 Bash Symposium. Latex with asp2006.sty. 4 pages, 4 figure

Morphological Transformations of Galaxies in the A901/02 Supercluster from STAGES

We present a study of galaxies in the Abell 901/902 Supercluster at z~0.165, based on HST ACS F606W, COMBO-17, Spitzer 24um, XMM-Newton X-ray, and gravitational lensing maps, as part of the STAGES survey. We characterize galaxies with strong externally-triggered morphological distortions and normal relatively undisturbed galaxies, using visual classification and quantitative CAS parameters. We compare normal and distorted galaxies in terms of their frequency, distribution within the cluster, star formation properties, and relationship to dark matter (DM) or surface mass density, and intra-cluster medium (ICM) density. We revisit the morphology density relation, which postulates a higher fraction of early type galaxies in dense environments, by considering separately galaxies with a low bulge-to-disk (B/D) ratio and a low gas content as these two parameters may not be correlated in clusters. We report here on our preliminary analysis.Comment: To appear in the ASP conference proceedings of the "Frank N. Bash Symposium 2007: New Horizons in Astronomy", Eds. A. Frebel, J. Maund, J. Shen, M. Siegel. 4 pages, 4 figure

Towards an understanding of the rapid decline of the cosmic star formation rate

We present a first analysis of deep 24 micron observations with the Spitzer Space Telescope of a sample of nearly 1500 galaxies in a thin redshift slice, 0.65<z<0.75. We combine the infrared data with redshifts, rest-frame luminosities, and colors from COMBO-17, and with morphologies from Hubble Space Telescope images collected by the GEMS and GOODS projects. To characterize the decline in star-formation rate (SFR) since z~0.7, we estimate the total thermal infrared (IR) luminosities, SFRs, and stellar masses for the galaxies in this sample. At z~0.7, nearly 40% of intermediate and high-mass galaxies (with stellar masses >2x10^10 solar masses) are undergoing a period of intense star formation above their past-averaged SFR. In contrast, less than 1% of equally-massive galaxies in the local universe have similarly intense star formation activity. Morphologically-undisturbed galaxies dominate the total infrared luminosity density and SFR density: at z~0.7, more than half of the intensely star-forming galaxies have spiral morphologies, whereas less than \~30% are strongly interacting. Thus, a decline in major-merger rate is not the underlying cause of the rapid decline in cosmic SFR since z~0.7. Physical properties that do not strongly affect galaxy morphology - for example, gas consumption and weak interactions with small satellite galaxies - appear to be responsible.Comment: To appear in the Astrophysical Journal 1 June 2005. 14 pages with 8 embedded figure