217 research outputs found
Effect of four-day psyllium supplementation on bowel preparation for colonoscopy:A prospective double blind randomized trial [ISRCTN76623768]
Health-related quality of life in French adolescents and adults: norms for the DUKE Health Profile
<p>Abstract</p> <p>Background</p> <p>The continual monitoring of population health-related quality of life (HRQoL) with validated instruments helps public health agencies assess, protect, and promote population health. This study aimed to determine norms for the French adolescent and adult general population for the Duke Health Profile (DUKE) questionnaire in a large representative community sample.</p> <p>Methods</p> <p>We randomly selected 17,733 French people aged 12 to 75 years old in 2 steps, by households and individuals, from the National Health Barometer 2005, a periodic population study by the French National Institute for Prevention and Health Education. Quality of life and other data were collected by computer-assisted telephone interview.</p> <p>Results</p> <p>Normative data for the French population were analyzed by age, gender and self-reported chronic disease. Globally, function scores (best HRQoL=100) for physical, mental, social, and general health, as well as perceived health and self-esteem, were 72.3 (SEM 0.2), 74.6 (0.2), 66.8 (0.1), 71.3 (0.1), 71.3 (0.3), 76.5 (0.1), respectively. Dysfunction scores (worst HRQoL=100) for anxiety, depression, pain and disability domains were 30.9 (0.1), 27.6 (0.2), 34.3 (0.3), 3.1 (0.1), respectively.</p> <p>Conclusion</p> <p>The French norms for adolescents and adults for the DUKE could be used as a reference for other studies assessing HRQoL, for specific illnesses, in France and for international comparisons.</p
Polyethylene glycol vs. sodium phosphate for bowel preparation: A treatment arm meta-analysis of randomized controlled trials
TESS Reveals a Short-period Sub-Neptune Sibling (HD 86226c) to a Known Long-period Giant Planet
The Transiting Exoplanet Survey Satellite mission was designed to find transiting planets around bright, nearby stars. Here, we present the detection and mass measurement of a small, short-period (â4 days) transiting planet around the bright (V = 7.9), solar-type star HD 86226 (TOI-652, TIC 22221375), previously known to host a long-period (~1600 days) giant planet. HD 86226c (TOI-652.01) has a radius of 2.16 ± 0.08 Râ and a mass of Mâ, based on archival and new radial velocity data. We also update the parameters of the longer-period, not-known-to-transit planet, and find it to be less eccentric and less massive than previously reported. The density of the transiting planet is 3.97 g cmâ3, which is low enough to suggest that the planet has at least a small volatile envelope, but the mass fractions of rock, iron, and water are not well-constrained. Given the host star brightness, planet period, and location of the planet near both the "radius gap" and the "hot Neptune desert," HD 86226c is an interesting candidate for transmission spectroscopy to further refine its composition
Variability of anti-staphylococcal antibodies in healthy volunteers and pre-cardiac surgery patients
TESS Hunt for Young and Maturing Exoplanets (THYME). III. A Two-planet System in the 400 Myr Ursa Major Group
Exoplanets can evolve significantly between birth and maturity as their
atmospheres, orbits, and structures are shaped by their environment. Young
planets (1 Gyr) offer the opportunity to probe these sculpting processes.
However, most of the known young planets orbit prohibitively faint stars. We
present the discovery of two planets transiting HD 63433 (TOI 1726, TIC
130181866), a young Sun-like () star. Through kinematics,
lithium abundance, and rotation, we confirm that HD 63433 is a member of the
Ursa Major moving group ( Myr). Based on the TESS light curve
and updated stellar parameters, the planet radii are and
, the orbital periods are 7.11 and 20.55 days, and the
orbital eccentricities are lower than abut 0.2. Using HARPS-N velocities, we
measure the Rossiter-McLaughlin signal of the inner planet, demonstrating the
orbit is prograde. Since the host star is bright (V=6.9), both planets are
amenable to transmission spectroscopy, radial velocity measurements of their
masses, and more precise determination of the stellar obliquity. This system is
therefore poised to play an important role in our understanding of planetary
system evolution in the first billion years after formation
Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein
Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and COPD exacerbations. There is currently no RV vaccine, largely due to the existence of âŒ150 strains. We aimed to define highly conserved areas of the RV proteome and test their usefulness as candidate antigens for a broadly cross-reactive vaccine, using a mouse infection model. Regions of the VP0 (VP4+VP2) capsid protein were identified as having high homology across RVs. Immunization with a recombinant VP0 combined with a Th1 promoting adjuvant induced systemic, antigen specific, cross-serotype, cellular and humoral immune responses. Similar cross-reactive responses were observed in the lungs of immunized mice after infection with heterologous RV strains. Immunization enhanced the generation of heterosubtypic neutralizing antibodies and lung memory T cells, and caused more rapid virus clearance. Conserved domains of the RV capsid therefore induce cross-reactive immune responses and represent candidates for a subunit RV vaccine
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