Olfactomedin‑like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon)

Background: The olfactomedin‑like domain (OLFML) is present in at least four families of proteins, including OLFML2A and OLFML2B, which are expressed in adult rat retina cells. However, no expression of their orthologous has ever been reported in human and baboon. Objective: The aim of this study was to investigate the expression of OLFML2A and OLFML2B in ocular tissues of baboons (Papio hamadryas) and humans, as a key to elucidate OLFML function in eye physiology. Methods: OLFML2A and OLFML2B cDNA detection in ocular tissues of these species was performed by RT‑PCR. The amplicons were cloned and sequenced, phylogenetically analyzed and their proteins products were confirmed by immunofluorescence assays. Results: OLFML2A and OLFML2B transcripts were found in human cornea, lens and retina and in baboon cornea, lens, iris and retina. The baboon OLFML2A and OLFML2B ORF sequences have 96% similarity with their human’s orthologous. OLFML2A and OLFML2B evolution fits the hypothesis of purifying selection. Phylogenetic analysis shows clear orthology in OLFML2A genes, while OLFML2B orthology is not clear. Conclusions: Expression of OLFML2A and OLFML2B in human and baboon ocular tissues, including their high simi‑ larity, make the baboon a powerful model to deduce the physiological and/or metabolic function of these proteins in the eye

Mixoma auricular con elementos glandulares

El mixoma es el tumor primario de corazón más común, y en aproximadamente 80% de los casos crece en la aurícula izquierda. La imagen histológica es característica y no representa un reto para el patólogo quirúrgico. En ocasiones, esta lesión adopta estructuras poco convencionales, como la formación de elementos glandulares, que ocurre en 3% de los casos. En este artículo se comunica el caso de una mujer de 42 años de edad con mixoma cardiaco de la aurícula derecha que contenía elementos glandulares. Es importante destacar la existencia de variantes, especialmente de este tipo histológico, tomar en cuenta los posibles diagnósticos diferenciales y sugerir el seguimiento a largo plazo de los pacientes