Lifetime quenching in Yb doped fibres

We have discovered that in ytterbium-doped silica fibres the excited state lifetime of a fraction of the Yb ions can be quenched to a very small value, leading to a strong unbleachable loss. This unexpected behaviour seems to be caused by some, yet unidentified, impurity or structural defect. It is of considerable relevance for various Yb doped lasers and-amplifiers including Er:Yb codoped fibres as used in telecommunication amplifiers although it should also be emphasized that fibres can be produced that are free from the quenching effect

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers

The expression level of the HER family is unreliable as a predictive marker for targeted therapies in cancer. Thus, there is a need to develop other biomarkers, which can be used to accurately select responsive patients for targeted therapies. The HER dimerization status may be more important than HER receptor expression per se in determining sensitivity or resistance to a given therapeutic agent. The aim of the study is to develop a FRET assay using dye conjugated secondary antibodies to assess HER receptor dimerization. Using primary antibodies from different species in conjunction with Alexa488 and Alexa546 conjugated secondary antibodies, we validated our EGFR/HER2 dimerization assay in three cell lines, EGFR positive A431 cells as well as HER2 positive breast cell lines BT474 and SKBR3 cells. Finally, we applied our assay to assess EGFR/HER2 dimerization in paraffin embedded cell pellets. Our results show promise for the assay to be applied to tumor samples in order to assess the prognostic significance and predictive value of HER receptor dimerization in various cancers

Infrared-induced photodarkening in Tm-doped fluoride fibres

We have observed a new type of infrared-induced photodarkening in high-numerical-aperture fluoride fibers doped with 3000 and 10,000 parts in 106 by weight of Tm. The loss induced in the visible region by 1140-nm radiation is very strong (as high as 25 dB in a 50-cm piece) and broadband it can be removed by irradiation with the same pump wavelength at lower powers

A 5000-year record of relative sea-level change in New Jersey, USA

Stratigraphic data from salt marshes provide accurate reconstructions of Holocene relative sea level (RSL) change and necessary constraints to models of glacial isostatic adjustment (GIA), which is the dominant cause of late Holocene RSL rise along the U.S. mid-Atlantic coast. Here, we produce a new mid- to late-Holocene RSL record from a salt marsh bordering Great Bay in southern New Jersey using basal peats. We use a multi-proxy approach (foraminifera and geochemistry) to identify the indicative meaning of the basal peats and produce sea-level index points (SLIPs) that include a vertical uncertainty for tidal range change and sediment compaction and a temporal uncertainty based on high precision Accelerator Mass Spectrometry radiocarbon dating of salt-marsh plant macrofossils. The 14 basal SLIPs range from 1211 ± 56 years BP to 4414 ± 112 years BP, which we combine with published RSL data from southern New Jersey and use with a spatiotemporal statistical model to show that RSL rose 8.6 m at an average rate of 1.7 ± 0.1 mm/yr (1σ) from 5000 years BP to present. We compare the RSL changes with an ensemble of 1D (laterally homogenous) and site-specific 3D (laterally heterogeneous) GIA models, which tend to overestimate the magnitude of RSL rise over the last 5000 years. The continued discrepancy between RSL data and GIA models highlights the importance of using a wide array of ice model and viscosity model parameters to more precisely fit site-specific RSL data along the U.S. mid-Atlantic coast

Radiocarbon Date List X: Baffin Bay, Baffin Island, Iceland, Labrador Sea, and the Northern North Atlantic

Date List X contains an annotated listing of 213 radiocarbon dates determined on samples from marine and terrestrial environments. The marine samples were collected from the East Greenland, Iceland, Spitzbergen, and Norwegian margins, Baffin Bay, and Labrador Sea. The terrestrial samples were collected from Vestfirdir, Iceland and Baffin Island. The samples were submitted by INSTAAR and researchers affiliated with INSTAAR\u27s Micropaleontology Laboratory under the direction of Dr.’s John T. Andrews and Anne E. Jennings. All of the dates from marine sediment cores were determined from either shells or foraminifera (both benthic and planktic). All dates were obtained by the Accelerator Mass Spectrometry (AMS) method. Regions of concentrated marine research include: Baffin Bay, Baffin Island, Labrador Sea, East Greenland fjords, shelf and slope, Denmark Strait, the southwestern and northwestern Iceland shelves, and Vestfirdir, Iceland. The non-marine radiocarbon dates are from peat, wood, plant microfossils, and mollusc. The radiocarbon dates have been used to address a variety of research objectives such as: 1. determining the timing of northern hemisphere high latitude environmental changes including glacier advance and retreat, and 2. assessing the accuracy of a fluctuating reservoir correction. Thus, most of the dates constrain the timing, rate, and interaction of late Quaternary paleoenvironmental fluctuations in sea level, glacier extent, sediment input, and changes in ocean circulation patterns. Where significant, stratigraphic and sample contexts are presented for each core to document the basis for interpretations

The Evidence for a Pentaquark Signal and Kinematic Reflections

Several recent experiments have reported evidence for a narrow baryon resonance with positive strangeness ($\Theta^+$) at a mass of 1.54 GeV/$c^2$. Baryons with $S=+1$ cannot be conventional $qqq$ states and the reports have thus generated much theoretical speculation about the nature of possible $S=+1$ baryons, including a 5-quark, or pentaquark, interpretation. We show that narrow enhancements in the $K^+n$ effective mass spectrum can be generated as kinematic reflections resulting from the decay of mesons, such as the $f_2(1275)$, the $a_2(1320)$ and the $\rho_3(1690)$.Comment: 4 pages, 4 figure

Lifetime quenching in Yb-doped fibres

We have discovered that in ytterbium-doped silica fibres the excited state lifetime of a fraction of the Yb ions can be quenched to a very small value, leading to a strong unbleachable loss. This unexpected behaviour seems to be caused by some, yet unidentified, impurity or structural defect. It is of considerable relevance for various Yb doped lasers and-amplifiers including Er:Yb codoped fibres as used in telecommunication amplifiers although it should also be emphasized that fibres can be produced that are free from the quenching effect

Universal Magnetic Properties of La2−δSrδCuO4La_{2-\delta} Sr_{\delta} Cu O_4 at Intermediate Temperatures

We present the theory of two-dimensional, clean quantum antiferromagnets with a small, positive, zero temperature ($T$) stiffness $\rho_s$, but with the ratio $k_B T / \rho_s$ arbitrary. Universal scaling forms for the uniform susceptibility ($\chi_u$), correlation length($\xi$), and NMR relaxation rate ($1/T_1$) are proposed and computed in a $1/N$ expansion and by Mont\'{e}-Carlo simulations. For large $k_B T/\rho_s$, $\chi_u (T)/T$ and $T\xi(T)$ asymptote to universal values, while $1/T_{1}(T)$ is nearly $T$-independent. We find good quantitative agreement with experiments and some numerical studies on $La_{2-\delta} Sr_{\delta} Cu O_4$.Comment: 14 pages, REVTEX, 1 postscript figure appende

Limiting Carleman weights and anisotropic inverse problems

In this article we consider the anisotropic Calderon problem and related inverse problems. The approach is based on limiting Carleman weights, introduced in Kenig-Sjoestrand-Uhlmann (Ann. of Math. 2007) in the Euclidean case. We characterize those Riemannian manifolds which admit limiting Carleman weights, and give a complex geometrical optics construction for a class of such manifolds. This is used to prove uniqueness results for anisotropic inverse problems, via the attenuated geodesic X-ray transform. Earlier results in dimension $n \geq 3$ were restricted to real-analytic metrics.Comment: 58 page

All solid-state blue room-temperature thulium-doped upconversion fibre laser

Following the report by Grubb we describe an all solid state, single wavelength pumped, cw, room temperature, upconversion laser which has operated in the blue between 475nm and 483nm or in the near infrared at 778nm. We have pumped this device at both longer and shorter wavelengths than those reported by Grubb. The system uses Yb-doped silica fibre to convert the output from a diode pumped Nd:YLF laser to a wavelength in the range 1.05µm to 1.18µm. This is used to pump a Tm-doped ZBLAN fibre giving rise to an upconversion process which involves the sequential absorption of three pump photons to populate the 1G4 upper laser level as shown in Fig 1