347 research outputs found
The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?
The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7 ± 3.7) women (65.6 ± 2.8 yrs) randomized to either a control (N = 11) or resistance training group (N = 12). The resistance trained group performed resistance training 3 days/week for 12 weeks. Resting blood samples were collected before and after the training intervention in both resistance trained and control groups. Resistance training upregulated melanocortin 3 receptor mRNA by 16-fold (P = .035) and decreased monocyte count, without changing leukocyte number, body composition, or body weight. Resistance trained individuals exhibited increased sensitivity to inflammatory stimuli, whereas control individuals exhibited no change. While there was no change in whole blood tumor necrosis factor alpha mRNA between the groups, whole blood interleukin 10 mRNA was higher in the resistance trained group following the intervention period. In summary, it appears that resistance training may modulate melanocortin 3 receptor expression, providing a possible mechanism for the anti-inflammatory effects of exercise training
Solid molecular hydrogen: The Broken Symmetry Phase
By performing constant-pressure variable-cell ab initio molecular dynamics
simulations we find a quadrupolar orthorhombic structure, of symmetry,
for the broken symmetry phase (phase II) of solid H2 at T=0 and P =110 - 150
GPa. We present results for the equation of state, lattice parameters and
vibronic frequencies, in very good agreement with experimental observations.
Anharmonic quantum corrections to the vibrational frequencies are estimated
using available data on H2 and D2. We assign the observed modes to specific
symmetry representations.Comment: 5 pages (twocolumn), 4 Postscript figures. To appear in Phys. Rev.
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The Mission Accessibility of Near-Earth Asteroids
The population of near-Earth asteroids (NEAs) that may be accessible for human space flight missions is defined by the Near-Earth Object Human Space Flight Accessible Targets Study (NHATS). The NHATS is an automated system designed to monitor the accessibility of, and particular mission opportunities offered by, the NEA population. This is analogous to systems that automatically monitor the impact risk posed to Earth by the NEA population. The NHATS system identifies NEAs that are potentially accessible for future round-trip human space flight missions and provides rapid notification to asteroid observers so that crucial follow-up observations can be obtained following discovery of accessible NEAs. The NHATS was developed in 2010 and was automated by early 2012. NHATS data are provided via an interactive web-site, and daily NHATS notification emails are transmitted to a mailing list; both resources are available to the public
High-Pressure Amorphous Nitrogen
The phase diagram and stability limits of diatomic solid nitrogen have been
explored in a wide pressure--temperature range by several optical spectroscopic
techniques. A newly characterized narrow-gap semiconducting phase has
been found to exist in a range of 80--270 GPa and 10--510 K. The vibrational
and optical properties of the phase produced under these conditions
indicate that it is largely amorphous and back transforms to a new molecular
phase. The band gap of the phase is found to decrease with pressure
indicating possible metallization by band overlap above 280 GPa.Comment: 5 pages, 4 figure
Structural Phase Transition at High Temperatures in Solid Molecular Hydrogen and Deuterium
We study the effect of temperature up to 1000K on the structure of dense
molecular para-hydrogen and ortho-deuterium, using the path-integral Monte
Carlo method. We find a structural phase transition from orientationally
disordered hexagonal close packed (hcp) to an orthorhombic structure of Cmca
symmetry before melting. The transition is basically induced by thermal
fluctuations, but quantum fluctuations of protons (deuterons) are important in
determining the transition temperature through effectively hardening the
intermolecular interaction. We estimate the phase line between hcp and Cmca
phases as well as the melting line of the Cmca solid.Comment: 8 pages, 7 figures; accepted in Phys. Rev.
Absence of Metallization in Solid Molecular Hydrogen
Being the simplest element with just one electron and proton the electronic
structure of the Hydrogen atom is known exactly. However, this does not hold
for the complex interplay between them in a solid and in particular not at high
pressure that is known to alter the crystal as well as the electronic
structure. Back in 1935 Wigner and Huntington predicted that at very high
pressure solid molecular hydrogen would dissociate and form an atomic solid
that is metallic. In spite of intense research efforts the experimental
realization, as well as the theoretical determination of the crystal structure
has remained elusive. Here we present a computational study showing that the
distorted hexagonal P6/m structure is the most likely candidate for Phase
III of solid hydrogen. We find that the pairing structure is very persistent
and insulating over the whole pressure range, which suggests that metallization
due to dissociation may precede eventual bandgap closure. Due to the fact that
this not only resolve one of major disagreement between theory and experiment,
but also excludes the conjectured existence of phonon-driven superconductivity
in solid molecular hydrogen, our results involve a complete revision of the
zero-temperature phase diagram of Phase III
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High Brightness, Laser-Driven X-ray Source for Nanoscale Metrology and Femtosecond Dynamics
This project developed and demonstrated a new, bright, ultrafast x-ray source based upon laser-driven K-alpha generation, which can produce an x-ray flux 10 to 100 times greater than current microfocus x-ray tubes. The short-pulse (sub-picosecond) duration of this x-ray source also makes it ideal for observing time-resolved dynamics of atomic motion in solids and thin films
Human Missions to Near-Earth Asteroids: An Update on NASA's Current Status and Proposed Activities for Small Body Exploration
Introduction: Over the past several years, much attention has been focused on the human exploration of near-Earth asteroids (NEAs). Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth-Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010. Dynamical Assessment: The current near-term NASA human spaceflight capability is in the process of being defined while the Multi-Purpose Crew Vehicle (MPCV) and Space Launch System (SLS) are still in development. Hence, those NEAs in more accessible heliocentric orbits relative to a minimal interplanetary exploration capability will be considered for the first missions. If total mission durations for the first voyages to NEAs are to be kept to less than one year, with minimal velocity changes, then NEA rendezvous missions ideally will take place within 0.1 AU of Earth (approx about 5 million km or 37 lunar distances). Human Exploration Considerations: These missions would be the first human expeditions to inter-planetary bodies beyond the Earth-Moon system and would prove useful for testing technologies required for human missions to Mars, Phobos and Deimos, and other Solar System destinations. Missions to NEAs would undoubtedly provide a great deal of technical and engineering data on spacecraft operations for future human space exploration while conducting detailed scientific investigations of these primitive objects. Current analyses of operational concepts suggest that stay times of 15 to 30 days may be possible at these destinations. In addition, the resulting scientific investigations would refine designs for future extraterrestrial In Situ Resource Utilization (ISRU), and assist in the development of hazard mitigation techniques for planetary defense. Conclusions: The scientific and hazard mitigation benefits, along with the programmatic and operational benefits of a human venture beyond the Earth-Moon system, make a piloted mission to a NEA using NASA's proposed human exploration systems a compelling endeavo
Missions to Near-Earth Asteroids: Implications for Exploration, Science, Resource Utilization, and Planetary Defense
Introduction: In 2009 the Augustine Commission identified near-Earth asteroids (NEAs) as high profile destinations for human exploration missions beyond the Earth-Moon system as part of the Flexible Path. More recently the U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010. NEA Space-Based Survey and Robotic Precursor Missions: The most suitable targets for human missions are NEAs in Earth-like orbits with long synodic periods. However, these mission candidates are often not observable from Earth until the timeframe of their most favorable human mission opportunities, which does not provide an appropriate amount of time for mission development. A space-based survey telescope could more efficiently find these targets in a timely, affordable manner. Such a system is not only able to discover new objects, but also track and characterize objects of interest for human space flight consideration. Those objects with characteristic signatures representative of volatile-rich or metallic materials will be considered as top candidates for further investigation due to their potential for resource utilization and scientific discovery. Once suitable candidates have been identified, precursor spacecraft are required to perform basic reconnaissance of a few NEAs under consideration for the human-led mission. Robotic spacecraft will assess targets for potential hazards that may pose a risk to the deep space transportation vehicle, its deployable assets, and the crew. Additionally, the information obtained about the NEA's basic physical characteristics will be crucial for planning operational activities, designing in-depth scientific/engineering investigations, and identifying sites on the NEA for sample collection. Human Exploration Considerations: These missions would be the first human expeditions to interplanetary bodies beyond the Earth-Moon system and would prove useful for testing technologies required for human missions to Mars, Phobos and Deimos, and other Solar System destinations. Current analyses of operational concepts suggest that stay times of 15 to 30 days may be possible at a NEA with total mission duration limits of 180 days or less. Hence, these missions would undoubtedly provide a great deal of technical and engineering data on spacecraft operations for future human space exploration while simultaneously conducting detailed investigations of these primitive objects with instruments and equipment that exceed the mass and power capabilities delivered by robotic spacecraft. All of these activities will be vital for refinement of resource characterization/identification and development of extraction/utilization technologies to be used on airless bodies under low- or micro-gravity conditions. In addition, gaining enhanced understanding of a NEA s geotechnical properties and its gross internal structure will assist the development of hazard mitigation techniques for planetary defense. Conclusions: The scientific, resource utilization, and hazard mitigation benefits, along with the programmatic and operational benefits of a human venture beyond the Earth-Moon system, make a piloted sample return mission to a NEA using NASA s proposed human exploration systems a compelling endeavor
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