Concept Negation in Free Text Components of Vaccine Safety Reports

Large amounts of information are locked up in free text components of clinical reports. Surveillance systems that monitor adverse events following immunizations (AEFI) can utilize these components after concept extraction using natural language processing (NLP). Specifically, our method for the identification and filtering of negated concepts using the Unified Medical Language System (UMLS) potentially improves the quality of AEFI surveillance systems

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Interpretation: First Nations and Métis adults responded robustly to ASO3-adjuvanted pandemic (H1N1) 2009 vaccine. Virtually all participants showed protective titres, including those with chronic health conditions. Trial registration: ClinicalTrials.gov trial register no. NCT.01001026. Abstrac

Integrating business process simulation and information system simulation for performance prediction

Business process (BP) designs and enterprise information system (IS) designs are often not well aligned. Missing alignment may result in performance problems at run-time, such as large process execution time or overloaded IS resources. The complex interrelations between BPs and ISs are not adequately understood and considered in development so far. Simulation is a promising approach to predict performance of both BP and IS designs. Based on prediction results, design alternatives can be compared and verified against requirements. Thus, BP and IS designs can be aligned to improve performance. In current simulation approaches, BP simulation and IS simulation are not adequately integrated. This results in limited prediction accuracy due to neglected interrelations between the BP and the IS in simulation. In this paper, we present the novel approach Integrated Business IT Impact Simulation (IntBIIS) to adequately reflect the mutual impact between BPs and ISs in simulation. Three types of mutual impact between BPs and ISs in terms of performance are specified. We discuss several solution alternatives to predict the impact of a BP on the performance of ISs and vice versa. It is argued that an integrated simulation of BPs and ISs is best suited to reflect their interrelations. We propose novel concepts for continuous modeling and integrated simulation. IntBIIS is implemented by extending the Palladio tool chain with BP simulation concepts. In a real-life case study with a BP and IS from practice, we validate the feasibility of IntBIIS and discuss the practicability of the corresponding tool support

Overview of the Alaskan Layered Pollution and Chemical Analysis (ALPACA) Field Experiment

The Alaskan Layered Pollution And Chemical Analysis (ALPACA) field experiment was a collaborative study designed to improve understanding of pollution sources and chemical processes during winter (cold climate and low-photochemical activity), to investigate indoor pollution, and to study dispersion of pollution as affected by frequent temperature inversions. A number of the research goals were motivated by questions raised by residents of Fairbanks, Alaska, where the study was held. This paper describes the measurement strategies and the conditions encountered during the January and February 2022 field experiment, and reports early examples of how the measurements addressed research goals, particularly those of interest to the residents. Outdoor air measurements showed high concentrations of particulate matter and pollutant gases including volatile organic carbon species. During pollution events, low winds and extremely stable atmospheric conditions trapped pollution below 73 m, an extremely shallow vertical scale. Tethered-balloon-based measurements intercepted plumes aloft, which were associated with power plant point sources through transport modeling. Because cold climate residents spend much of their time indoors, the study included an indoor air quality component, where measurements were made inside and outside a house to study infiltration and indoor sources. In the absence of indoor activities such as cooking and/or heating with a pellet stove, indoor particulate matter concentrations were lower than outdoors; however, cooking and pellet stove burns often caused higher indoor particulate matter concentrations than outdoors. The mass-normalized particulate matter oxidative potential, a health-relevant property measured here by the reactivity with dithiothreiol, of indoor particles varied by source, with cooking particles having less oxidative potential per mass than pellet stove particles

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

Over 100 genetic loci harbor schizophrenia associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of schizophrenia cases (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ~20% of schizophrenia loci have variants that could contribute to altered gene expression and liability. In five loci, only a single gene was involved: FURIN, TSNARE1, CNTN4, CLCN3, or SNAP91. Altering expression of FURIN, TSNARE1, or CNTN4 changes neurodevelopment in zebrafish; knockdown of FURIN in human neural progenitor cells yields abnormal migration. Of 693 genes showing significant case/control differential expression, their fold changes are ≤ 1.33, and an independent cohort yields similar results. Gene co-expression implicates a network relevant for schizophrenia. Our findings show schizophrenia is polygenic and highlight the utility of this resource for mechanistic interpretations of genetic liability for brain diseases