568 research outputs found
Letter to Diana Osbaldiston regarding SEAALL membership dues, March 21, 1989
A letter from Barbara Jacobson to Diana Osbaldiston asking Osbaldiston for information regarding the membership dues payment for the Marshall-Wythe Law Library
Evaluation of the Wellspring Model for Improving Nursing Home Quality
Examines how successfully the Wellspring model improved the quality of care for residents of eleven nonprofit nursing homes in Wisconsin. Looks at staff turnover, and evaluates the impact on facilities, employees, residents, and cost
Analysis of Sports Injuries among High School Athletes in 18 West Central Florida Schools
Through this study we report the 2014-15 injuries of high school athletes in 18 west central Florida schools utilizing the Reporting Information Online (RIO) data system. Certified athletic trainers (ATCs) were hired and trained by researchers from the University of South Florida to collect and report injury findings from high school athletes. Descriptive statistics, injury rates, and rate ratios were calculated. Overall, 726 injuries were reported by the ATCs. Football was the leading sport for number of injuries and injuries per athlete-exposures for practices and competitions. Boys had significantly greater injury rates compared to girls overall and in competitions and practices. Our results show the important role football continues to play in high school sports injuries and help lay the groundwork for the development of targeted interventions for athletes
Family, Gender, and Population Policy: Views from the Middle East [Arabic]
This paper explores the relevance of international debates to the realities of the Middle East, an important but understudied region that has often been subject to stereotyping. The regionâs wealth of traditions and diverse contemporary experience offer insights to those who venture beyond the surface appearance. This paper provides a broad introduction to the connections between family, gender, and population policy in the Middle East. It is based on studies by a diverse group of Middle East scholars and the discussions they generated in Cairo at an international symposium sponsored by the Population Council in February 1994. The paper was written prior to the historic UN International Conference on Population and Development in Egypt, in the hope both of increasing understanding of an important region of the world and refining our grasp of international issues
Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus
Activation of innate sensors by self-antigen contributes to autoimmunity, although how intracellular sensors are chronically exposed to self-antigen has remained unknown. Here, we identify a previously unidentified defect in which lupus-prone macrophages fail to mature the lysosome, promoting the accumulation of apoptotic debris-containing IgGâimmune complexes (IgG-ICs). Interestingly, macrophages from other autoimmune diseases accumulate IgG-ICs, indicating that lysosomal defects may underlie multiple autoimmune diseases. Furthermore, the prolonged intracellular residency chronically activates Toll-like receptors and permeabilizes the phagolysosomal membrane, allowing activation of cytosolic sensors. These findings identify lysosomal maturation as a unique defect in MRL/lpr mice that impacts multiple events known to underlie SLE, including pathogenic cytokine secretion
Four problems with global carbon markets: a critical review
This article offers a critique of global carbon markets and trading, with a special focus on the Clean Development Mechanism of the Kyoto Protocol. It explores
problems with the use of tradable permits to address climate change revolving around four areas: homogeneity, justice, gaming, and information. Homogeneity problems arise from the non-linear nature of climate change and sensitivity of emissions, which complicate attempts to calculate carbon offsets. Justice problems involve issues of dependency and the concentration of wealth among the rich, meaning carbon trading often counteracts attempts to reduce poverty. Gaming problems include pressures to promote high-volume, least-cost projects and the
consequences of emissions leakage. Information problems encompass transaction costs related to carbon trading and market participation and the comparatively weak institutional capacity of project evaluators
WIYN Open Cluster Study. XXXIX. Abundances in NGC 6253 from HYDRA Spectroscopy of the Li 6708 A Region
High-dispersion spectra of 89 potential members of the old, super-metal-rich
open cluster, NGC 6253, have been obtained with the HYDRA multi-object
spectrograph. Based upon radial-velocity measurements alone, 47 stars at the
turnoff of the cluster color-magnitude diagram (CMD) and 18 giants are
identified as potential members. Five turnoff stars exhibit evidence of
binarity while proper-motion data eliminates two of the dwarfs as members. The
mean cluster radial velocity from probable single-star members is -29.4 +/- 1.3
km/sec (sd). A discussion of the current estimates for the cluster reddening,
derived independently of potential issues with the BV cluster photometry, lead
to an adopted reddening of E(B-V) = 0.22 +/- 0.04. From equivalent width
analyses of 38 probable single-star members near the CMD turnoff, the weighted
average abundances are found to be [Fe/H] = +0.43 +/- 0.01, [Ni/H] = +0.53 +/-
0.02 and [Si/H] = +0.43 (+0.03,-0.04), where the errors refer to the standard
errors of the weighted mean. Weak evidence is found for a possible decline in
metallicity with increasing luminosity among stars at the turnoff. We discuss
the possibility that our turnoff stars have been affected by microscopic
diffusion. For 15 probable single-star members among the giants, spectrum
synthesis leads to abundances of +0.46 (+0.02,-0.03) for [Fe/H]. While less
than half the age of NGC 6791, NGC 6253 is at least as metal-rich and, within
the uncertainties, exhibits the same general abundance pattern as that typified
by super-metal-rich dwarfs of the galactic bulge.Comment: 5 Tables, 9 figures, 45 page
Amyloid Myopathy as an Inclusion Body Myositis Mimic
Introduction: Amyloid myopathy is a rare presentation of systemic amyloidosis. Amyloid myopathy can be initially misdiagnosed as sporadic inclusion body myositis (IBM).
Methods: We report 4 cases of amyloid myopathy clinically mimicking inclusion body myositis and initially thought to be phenotypically IBM by neuromuscular experts.
Results: Case 1 is an 81-year-old woman who presented with distal arm and proximal leg asymmetric weakness (myopathy pattern 4). Case 2 is a 76-year-old man with primary systemic amyloidosis who presented with myopathy pattern 4 and progressive dysphagia for four years. Case 3 is an 82-year-old man with progressive myopathy pattern 4 weakness and swallowing difficulty. Case 4 is a 62-year-old man with progressive bilateral finger flexor weakness. Muscle biopsies in all 4 cases showed perivascular amyloid deposits
Discussion: Amyloid myopathy may be clinically indistinguishable from IBM. Muscle biopsy is of critical importance in the evaluation of patients suspected to have IBM
Self-Care for the Prevention and Management of Cardiovascular Disease and Stroke: A Scientific Statement for Healthcare Professionals from the American Heart Association
Selfâcare is defined as a naturalistic decisionâmaking process addressing both the prevention and management of chronic illness, with core elements of selfâcare maintenance, selfâcare monitoring, and selfâcare management. In this scientific statement, we describe the importance of selfâcare in the American Heart Association mission and vision of building healthier lives, free of cardiovascular diseases and stroke. The evidence supporting specific selfâcare behaviors such as diet and exercise, barriers to selfâcare, and the effectiveness of selfâcare in improving outcomes is reviewed, as is the evidence supporting various individual, familyâbased, and communityâbased approaches to improving selfâcare. Although there are many nuances to the relationships between selfâcare and outcomes, there is strong evidence that selfâcare is effective in achieving the goals of the treatment plan and cannot be ignored. As such, greater emphasis should be placed on selfâcare in evidenceâbased guidelines
In Situ Photoactivation of a Caged Phosphotyrosine Peptide Derived from Focal Adhesion Kinase Temporarily Halts Lamellar Extension of Single Migrating Tumor Cells
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, mediates integrin-based cell signaling by transferring signals regulating cell migration, adhesion, and survival from the extracellular matrix to the cytoplasm. Following autophosphorylation at tyrosine 397, FAK binds the Src homology 2 domains of Src and phosphoinositide 3-kinase, among several other possible binding partners. To further investigate the role of phosphorylated FAK in cell migration in situ, peptides comprising residues 391-406 of human FAK with caged phosphotyrosine 397 were synthesized. Although the caged phosphopeptides were stable to phosphatase activity, the free phosphopeptides showed a half-life of approximately 10-15 min in cell lysates. Migrating NBT-II cells (a rat bladder tumor cell line) were microinjected with the caged FAK peptide and locally photoactivated using a focused laser beam. The photoactivation of caged FAK peptide in 8-microm diameter spots over the cell body led to the temporary arrest of the leading edge migration within approximately 1 min of irradiation. In contrast, cell body migration was not inhibited. Microinjection of a non-caged phosphorylated tyrosine 397 FAK peptide into migrating NBT-II cells also led to lamellar arrest; however, this approach lacks the temporal control afforded by the caged phosphopeptides. Photoactivation of related phosphotyrosine peptides with altered sequences did not result in transient lamellar arrest. We hypothesize that the phosphorylated FAK peptide competes with the endogenous FAK for binding to FAK effectors including, but not limited to, Src and phosphoinositide 3-kinase, causing spatiotemporal misregulation and subsequent lamellar arrest
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