Catherine Colomb’s VISION OF TIME: in Dialogue with Marcel Proust and Virginia Woolf

This monograph is the first substantial contribution to the study of the Swiss novelist Catherine Colomb’s dialogue with Marcel Proust and Virginia Woolf as well as to time and memory studies. The framework and approach devised to examine Colomb’s oeuvre contribute to unravelling some of its complexities, not only in its curving style, ephemeral, and sequence-defying narrative, but also in its literary engagement with the science and philosophy that shaped modernity and proposed new ways of thinking time, knowledge, and the human experience. This thesis ultimately allows us to gain insight into the originality of Colombian time experience, memory, and point-of-view representations, transcending the alleged influence of her iconic predecessors

Analysis of impact of demographic factors on the consumption of organic foods in green marketing perspective: an international survey-based study

This paper aims to identify the factors which affect the consumption of organic foods such as natural milk and olive oil on an international scale. It should be mentioned that the factors examined are gender, age, nationality, educational level, and occupation of consumers. The study was explored through an online survey between January-November 2022 among 155 respondents from 14 countries; most of them are from Turkey, Algeria, Pakistan, Georgia, and India. Then, the results were analysed through SPSS software V26. As results, the independence between the consumption of organic food and the demographics variables is confirmed. It means that all corposants of each variable are related to the consumption of organic product. Indeed, the limit of this study is in the number of sampled population (155), besides, some countries such as Libya, France, Mali; Italy; and Ethiopia are represented by one participant for each country. Consequently, the result obtained can’t be generatedd all worldwide. The same observation for some occupations (Judge, Nurse, Pharmacist and dentist), are not fully sufficient to be analysed further

A picture of medically assisted reproduction activities during the COVID-19 pandemic in Europe

STUDY QUESTION: How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)? SUMMARY ANSWER: MAR services, and hence treatments for infertile couples, were stopped in most European countries for a mean of 7 weeks. WHAT IS KNOWN ALREADY: With the outbreak of COVID-19 in Europe, non-urgent medical care was reduced by local authorities to preserve health resources and maintain social distancing. Furthermore, ESHRE and other societies recommended to postpone ART pregnancies as of 14 March 2020. STUDY DESIGN, SIZE, DURATION: A structured questionnaire was distributed in April among the ESHRE Committee of National Representatives, followed by further information collection through email. PARTICIPANTS/MATERIALS, SETTING, METHODS: The information was collected through the questionnaire and afterwards summarised and aligned with data from the European Centre for Disease Control on the number of COVID-19 cases per country. MAIN RESULTS AND THE ROLE OF CHANCE: By aligning the data for each country with respective epidemiological data, we show a large variation in the time and the phase in the epidemic in the curve when MAR/ART treatments were suspended and restarted. Similarly, the duration of interruption varied. Fertility preservation treatments and patient supportive care for patients remained available during the pandemic. LARGE SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: Data collection was prone to misinterpretation of the questions and replies, and required further follow-up to check the accuracy. Some representatives reported that they, themselves, were not always aware of the situation throughout the country or reported difficulties with providing single generalised replies, for instance when there were regional differences within their country. WIDER IMPLICATIONS OF THE FINDINGS: The current article provides a basis for further research of the different strategies developed in response to the COVID-19 crisis. Such conclusions will be invaluable for health authorities and healthcare professionals with respect to future similar situations.peer-reviewe

Catherine Colomb’s VISION OF TIME: in Dialogue with Marcel Proust and Virginia Woolf

This monograph is the first substantial contribution to the study of the Swiss novelist Catherine Colomb’s dialogue with Marcel Proust and Virginia Woolf as well as to time and memory studies. The framework and approach devised to examine Colomb’s oeuvre contribute to unravelling some of its complexities, not only in its curving style, ephemeral, and sequence-defying narrative, but also in its literary engagement with the science and philosophy that shaped modernity and proposed new ways of thinking time, knowledge, and the human experience. This thesis ultimately allows us to gain insight into the originality of Colombian time experience, memory, and point-of-view representations, transcending the alleged influence of her iconic predecessors

Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia

Objective Hypoxia or exposure to excessive reactive oxygen or nitrogen species could induce S-nitrosylation of various target proteins, including GTPases of the Ras-superfamily. Under hypoxic conditions, the Ras-protein is translocated to the cytosol and interacts with the Golgi complex, endoplasmic reticulum, mitochondria. The mobility/translocation of Ras depend on the cells oxidative status. However, the importance of relocated S-nitrosylated-H-Ras (NO-H-Ras) in proliferation/differentiation processes is not completely understood. We have determined the content of soluble- and membrane-bound-NO-H-Ras in differentiated (D) and undifferentiated (ND) rat pheochromocytoma (PC12) cells under hypoxic and normoxic conditions. Materials and Methods In our experimental study, we analyzed NO-H-Ras levels under hypoxic/normoxic conditions in membrane and soluble fractions of ND and D PC12 cells with/without nitric oxide donor, sodium nitroprusside (SNP) treatment. Cells were analyzed by the S-nitrosylated kit, immunoprecipitation, and Western blot. We assessed the action of NO-H-Ras on oxidative metabolism of isolated mitochondria by determining mitochondrial hydrogen peroxide generation via the scopoletin oxidation method and ATP-production as estimated by the luminometric method. Results Hypoxia did not influence nitrosylation of soluble H-Ras in ND PC12 cells. Under hypoxic conditions, the nitrosylation of soluble-H-Ras greatly decreased in D PC12 cells. SNP didn’t change the levels of nitrosylation of soluble-H-Ras, in either hypoxic or normoxic conditions. On the other hand, hypoxia, per se, did not affect the nitrosylation of membrane-bound-H-Ras in D and ND PC12 cells. SNP-dependent nitrosylation of membrane-bound-H-Ras greatly increased in D PC12 cells. Both unmodified normal and mutated H-Ras enhanced the mitochondrial synthesis of ATP, whereas the stimulatory effects on ATP synthesis were eliminated after S-nitrosylation of H-Ras. Conclusion According to the results, it may be proposed that hypoxia can decrease S-nitrosylation of soluble-H-Ras in D PC12 cells and abolish the inhibitory effect of NO-H-Ras in mitochondrial oxidative metabolism