13 research outputs found
Direct Functionalization of (Un)protected Tetrahydroisoquinoline and Isochroman under Iron and Copper Catalysis: Two Metals, Two Mechanisms
Vestibular histofluorescence could be due to accumulation of both the antibiotic and its derivative, streptidine, after acute streptomycin treatment in the guinea pig
Acute treatment with 300 mglkg of pigmented guinea pigs with streptomycin sulfate induces an elevation of endogenous fluorescence in vestibular ampullary cristae. Fluorescence accumulates in all compartments of the epithelium, i.e., vestibular sensory and supporting cells and nerve fibers of the stroma and it was very intense 1 and 12 hours after its administration. Fli~orescence decreased to control levels 24 hours following streptomycin injection. Fluorescence levels were very low either in untreated animals or in animals injected with s a l i n e physiological solution. To investigate whether this fluorescence was an intrinsic property of the antibiotic or whether it was due to a derivative of it, or both, an in vitro fluorescence spectrum was performed with 100 ÎŒM solutions of streptomycin or streptidine, or both, dissolved in various buffer solutions at 488 nm of excitation.A discrete level of fluorescence was observed in the spectrum regardless of media when separate solutions of both streptomycin or streptidine were studie d . Fluorescence notably increased at 522-532 nm when the solutions contained both streptomycin and streptidine toget her.These results suggest that streptidine putatively derived from streptomycin may contribute to the observed fluorescence accumulation in vestibular preparations after acute treatment. Thus, these metabolic properties of the inner ear which transform streptomycin into streptidine, something never considered earlier, could be claimed as partially responsible for converting a therapeutic agent into a compound which could be as harmful as STP to the inner ear
Vestibular histofluorescence could be due to accumulation of both the antibiotic and its derivative, streptidine, after acute streptomycin treatment in the guinea pig
Acute treatment with 300 mglkg of
pigmented guinea pigs with streptomycin sulfate induces
an elevation of endogenous fluorescence in vestibular
ampullary cristae. Fluorescence accumulates in all
compartments of the epithelium, i.e., vestibular sensory
and supporting cells and nerve fibers of the stroma and it
was very intense 1 and 12 hours after its administration.
Fli~orescence decreased to control levels 24 hours
following streptomycin injection. Fluorescence levels
were very low either in untreated animals or in animals
injected with s a l i n e physiological solution. To
investigate whether this fluorescence was an intrinsic
property of the antibiotic or whether it was due to a
derivative of it, or both, an in vitro fluorescence
spectrum was performed with I00 ,LIM solutions of
streptomycin or streptidine, or both, dissolved in various
buffer solutions at 488 nm of excitation.
A discrete level of fluorescence was observed in the
spectrum regardless of media when separate solutions of
both streptomycin or streptidine were s t u d i e d .
Fluorescence notably increased at 522-532 nm when the
solutions contained both streptomycin and streptidine
toget her.
These results suggest that streptidine putatively derived from streptomycin may contribute to the
observed fluorescence accumulation in vestibular
preparations after acute treatment. Thus, these metabolic
properties of the inner ear which transform streptomycin
into streptidine, something never considered earlier,
could be claimed as partially responsible for converting
a therapeutic agent into a compound which could be as
harmful as STP to the inner ear
Crystal and molecular structures of 5,7-dimethyl-1,8-naphthyridine-2-ol (=LH) and of its mercury (II) complex HgL2 and synthesis of some lanthanide/HgL2 heterometallic complexes
Structure and magnetic properties of copper(II) and cobalt(II) coordination compounds derived from optically active tridentate ligands
International audienc
2,6-Bis(2,6-diethylphenyliminomethyl)pyridine coordination compounds with cobalt(II), nickel(II), copper(II), and zinc(II): synthesis, spectroscopic characterization, X-ray study and in vitro cytotoxicity
Metals in Catalysis, Biomimetics & Inorganic Material