32 research outputs found

    Lutzomyia longipalpis urbanisation and control

    Full text link

    Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits

    No full text
    The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK).Peer reviewe
    corecore