Клиническая настороженность к завозной малярии: прививные случаи и смертельные исходы в России

In the Russian Federation, up to 100 cases of imported malaria are registered annually, more than half of them are tropical malaria (Plasmodium falciparum). The absence of antimalarial drugs in the country, the late treatment of patients for medical care, errors in clinical diagnosis and treatment annually lead to deaths. For 2013-2016 they were 9, and in 2017 - 5. In such a situation, the experience of optimizing the treatment of severe forms of tropical malaria is particularly useful, which reduces mortality from 84 to 6.8%.В Российской Федерации ежегодно регистрируют до 100 случаев завозной малярии, более половины из них - тропической (Plasmodium falciparum). Отсутствие в стране противомалярийных лекарственных препаратов, позднее обращение заболевших за медицинской помощью, ошибки клинической диагностики и лечения ежегодно приводят к летальным исходам. За 2013-2016 гг. их было 9, а в 2017 г. - 5. В такой ситуации особенно полезен опыт оптимизации лечения тяжелых форм тропической малярии, позволяющий снизить летальность с 84 до 6,8%

Problems of clinical diagnosis and treatment of P. Falciparum malaria in Russian Federation

Aim. To study the causes of falciparum malaria deaths in Russian Federation and to optimize therapy for severe forms of the disease. Materials and methods. The analysis of falciparum malaria cases with deaths recorded in Russian Federation from 2013 to 2017 was conducted. The results of optimization of pathogenetic therapy of severe forms of falciparum malaria for the prevention of adverse outcomes in the intensive care unit of the Infectious Clinical Hospital №2 of Moscow in 44 patients with severe course are presented. Treatment, clinical laboratory and instrumental investigations were carried out in accordance with our intensive care protocol, which took into account the current WHO recommendations. Results. From 2013 to 2017 there were nine deaths from falciparum malaria reported in patients from African countries (6) and India (3). In Russia, due to the lack of effective drugs of artemisinin group, quinine with tetracycline or doxycycline is used for etiotropic therapy of patients with complicated form of falciparum malaria. In the management of such patients, the basis for treatment was the prevention of is-chemic, reperfusion injuries of organs and hemorrhagic complications. In the infectious clinical hospital №2 of Moscow, since 2007, the intensive care unit has developed and tested a protocol for intensive therapy in patients with severe and complicated forms of falciparum malaria, including preventive methods of extracorporeal hemocorrection with prolonged veno-venous hemodiafiltration therapy and plasmapheresis, as a result of which the mortality rate decreased from 84 to 6.8% Conclusion. The country's lack of anti-malarial drugs, the insufficient awareness of the population about the risk of infection and measures to prevent malaria, late referral of cases for medical care and errors of clinical diagnosis and treatment annually lead to fatal outcomes. In such situation, the experience of optimizing the treatment of severe falciparum malaria is particularly useful, allowing decreasing the mortality. © 2018 Media Sphera Publishing Group.All Rights Reserved

The Length of Telomeres and the Baseline Level of Cytogenetic Damage in Leukocytes of Lung Cancer Patients

International audienceAbstract: Despite the great efforts of basic and clinical research on lung cancer (LC), the prevention and treatment of this type of cancer show still far from satisfactory indicators. The complex mechanisms of the LC biology are already recognized, but there is a significant gap in the knowledge about the interaction of key biomarkers in the etiology and progression of this disease. The present work is aimed at studying the relationship between the telomere length (TL) and frequencies of chromosomal aberrations (CA) and micronuclei (MN) in leukocytes of primary lung cancer patients. In 67 men with lung cancer and 77 control donors (men), the baseline frequencies of CA and MN were determined in blood leukocytes, and TL was also studied. As a result, a significant increase in TL was found in lung cancer patients compared with control donors (25.86 ± 2.13 versus 15.29 ± 1.22, respectively, p = 0.00001). In leukocytes of LC patients, a significant increase in the baseline level of structural aberrations of chromosomes, as well as micronuclei containing centromeres, was noted. Only in the sample of lung cancer patients were direct correlations of TL with the frequency of chromosomal type aberrations and with the frequency of paired fragments revealed. In the same sample, significant inverse correlations of TL with the frequency of binucleated leukocytes containing nuclear protrusions and with the frequency of cells entering apoptosis were recorded. The study first showed that an increase in TL in lung cancer patients is associated with structural chromosomal damages, but not with the incidence of aneuploidies