Age-Related Difference in Cognitive Performance under Severe Whole-Body Hyperthermia Parallels Cortisol and Physical Strain Responses

Background and Objectives: To date, understanding age-related changes in cognitive processes during heat exposure still needs to be better-understood. Thus, the main aim of the current study was to evaluate the effects of whole-body hyperthermia (WBH), i.e., a ≈ 2.5 °C increase in rectal temperature (Tre) from overnight-fast baseline value, on cognitive functioning in old and young men and to explore factors, such as stress and thermophysiological strain, that could influence such changes. Materials and Methods: Ten young (19–21 years of age) and nine old (61–80 years of age) healthy men underwent an experimental trial with passive lower-body heating in hot water immersion (HWI) at 43 °C (HWI–43 °C) until Tre reached 39 °C in old adults and 39.5 °C in young adults. Cognitive performance and cortisol concentration were assessed before and after HWI, and the physiological strain index (PSI) was assessed during HWI–43 °C. Results: PSI was lower and cortisol concentration was greater after HWI–43 °C in the old group compared with the young group (p Conclusions: A ≈ 2.5 °C increase in rectal temperature can improve executive function in old adults, and this increase parallels the increased cortisol concentration and the lower thermophysiological strain under severe WBH conditions

Modulation of neuromuscular excitability in response to acute noxious heat exposure has no additional effects on central and peripheral fatigability

Background: Whole-body hyperthermia (WBH) has an adverse effect on the nervous system and neurophysiological performance. In the present study, we examined whether short-duration whole-body immersion in 45°C water (HWI-45°C), which produces a strong neural and temperature flux without inducing WBH, can increase or impair neurophysiological performance in humans. Methods: Fifteen men (aged 25 ± 6 years) were enrolled in this study and participated in three experiments: 1) a brief (5-min) immersion of the whole body in 37°C water (WI-37°C); 2) a brief (5-min) HWI-45°C; and 3) a control trial in a thermoneutral condition at an ambient temperature of 24°C and 60% relative humidity. Before and after the immersions, neuromuscular function (electromyographic activity, reflexes, electrically and voluntary induced torque production, voluntary muscle activation level) were tested. To provoke central inhibition, the participants performed a sustained 2-min maximal voluntary contraction (MVC). Results: Thermophysiological strain was greater after HWI-45°C than after WI-37°C. Electrophysiological modulations of motor drive transmission and peripheral modulations of muscle contractility properties in response to HWI-45°C seemed to have little effect on central activation of the exercising muscles and no effect on MVC production. Conclusion: Although exposure to acute noxious heat was effective in evoking neuromuscular excitability, the increases in core temperature (∼0.2°C) and muscle temperature (∼0.6°C) did not induce moderate or severe WBH. These changes did not seem to affect central structures; that is, there were no additional increases in central and/or peripheral fatigue during a sustained 2-min MVC

Physiological and Psychological Responses during Exercise and Recovery in a Cold Environment Is Gender-Related Rather Than Fabric-Related

We evaluated gender-specific effects of two types of undergarments on exercise-induced physiological and psychological stress and subsequent recovery in cold conditions for male and female participants. Ten healthy men and eleven healthy women (25.0 ± 1.5 versus 23.4 ± 1.2 years old, respectively) completed the experimental session twice with two different types of undergarments: polyester or merino wool leggings and long-sleeve tops; specifically, merino fabric had greater thermal resistance and water absorbency, and less water vapor as well as air permeability than polyester. Experimental sessions involved performing 1 h of exercise on a cycle ergometer at 8°C ambient temperature and 55% relative humidity, holding at 70–80 revolutions per minute and 60% of each participant’s predetermined maximal power output (assessed by maximal oxygen uptake test), followed by 1 h recovery in the same environment. Every 5 min during exercise and every 10 min during recovery, rectal temperature, heart rate, subjective ratings for thermal, shivering/sweating and clothing wetness sensations, and clothing next-to-skin and outer side surface temperature and humidity on the chest, back and thigh were recorded. All participants experienced high physiological stress (assessed by physiological strain index) during exercise. No significant gender differences were found in core temperature or heart rate changes during exercise, but women cooled down faster during recovery. Next-to-skin humidity was similar between genders and different garment sets during exercise and recovery, but such temperatures at the chest during exercise and at the thigh during exercise and recovery were lower in women with both sets of garments. Subjective thermal sensations were similar in all cases. In the last 20 min of cycling, women started to feel wetter than men (P < 0.05) for both garment sets. Shivering was reported as stronger in women in the last 10 min of recovery. Most of the changes in the garment microclimates during exercise and recovery in the cold were associated with gender-related differences rather than with fabric-related differences

Time course of physiological and psychological responses in humans during a 20-day severe- cold–acclimation programme

The time course of physiological and psychological markers during cold acclimation (CA) was explored. The experiment included 17 controlled (i.e., until the rectal temperature reached 35.5°C or 170 min had elapsed; for the CA-17 session, the subjects (n = 14) were immersed in water for the same amount of time as that used in the CA-1 session) head-out water immersions at a temperature of 14°C over 20 days. The data obtained in this study suggest that the subjects exhibited a thermoregulatory shift from peripheral-to-central to solely central input thermoregulation, as well as from shivering to non-shivering thermogenesis throughout the CA. In the first six CA sessions, a hypothermic type of acclimation was found; further CA (CA-7 to CA-16) led to a transitional shift to a hypothermic-insulative type of acclimation. Interestingly, when the subjects were immersed in water for the same time as that used in the CA-1 session (CA-17), the CA led to a hypothermic type of acclimation. The presence of a metabolic type of thermogenesis was evident only under thermoneutral conditions. Cold-water immersion decreased the concentration of cold-stress markers, reduced the activity of the innate immune system, suppressed specific immunity to a lesser degree and yielded less discomfort and cold sensation. We found a negative correlation between body mass index and Δ metabolic heat production before and after CA

Response to three weeks of sprint interval training cannot be explained by the exertional level

Background and Objectives: The all-out mode of sprint interval training (SIT) has been shown to be an efficient method for improving sports performance, exercise capacity, and aerobic fitness. Although the benefits of SIT are well described, the mechanisms underlying the different degrees of response remain largely unexplored. We aimed to assess the effects of exertion on the responsiveness to SIT. Materials and Methods: The participants were 28 young untrained men (mean ± SD age 25.7 ± 6.03 years) who exhibited either a large or small increase in Wingate test average power in response to nine SIT sessions performed over three weeks. Each training session comprised four-six bouts of 30 s all-out cycling interspaced with 4 min of rest. Individual responses were assessed using heart rate (HR) during exercise for all nine sessions, as well as blood lactate concentration up to 1 h, and the decrement in maximal voluntary knee extension torque (MVC) up to 24 h after the first and last training sessions. Peak oxygen uptake (VO2peak) and maximum HR were measured before and after training during an incremental cycling test to exhaustion. Results: Although all participants showed benefits of SIT such as increased VO2peak, the increase in anaerobic cycling power varied between participants. We identified 17 high responders and nine low responders, whose average power outputs were 0.80 ± 0.22 and 0.22 ± 0.19 W/kg, respectively. The HR achieved during any of the training sessions did not differ between high and low responders. The lactate kinetics did not differ between groups before and after the intervention. Training resulted in a more rapid recovery of MVC without any discernible differences between the high and low responders. Conclusion: The differences in the responses to SIT are not dependent on the exertion level during training

Modulation of endothelial glycocalyx and microcirculation in healthy young men during high-intensity sprint interval cycling-exercise by supplementation with pomegranate extract. a randomized controlled trial

The natural components of the pomegranate fruit may provide additional benefits for endothelial function and microcirculation. It was hypothesized that supplementation with pomegranate extract might improve glycocalyx properties and microcirculation during acute high-intensity sprint interval cycling exercise. Eighteen healthy and recreationally active male volunteers 22-28 years of age were recruited randomly to the experimental and control groups. The experimental group was supplemented with pomegranate extract 20 mL (720 mg phenolic compounds) for two weeks. At the beginning and end of the study, the participants completed a high-intensity sprint interval cycling-exercise protocol. The microcirculation flow and density parameters, glycocalyx markers, systemic hemodynamics, lactate, and glucose concentration were evaluated before and after the initial and repeated (after 2 weeks supplementation) exercise bouts. There were no significant differences in the microcirculation or glycocalyx over the course of the study (p < 0.05). The lactate concentration was significantly higher in both groups after the initial and repeated exercise bouts, and were significantly higher in the experimental group compared to the control group after the repeated bout: 13.2 (11.9-14.8) vs. 10.3 (9.3-12.7) mmol/L, p = 0.017. Two weeks of supplementation with pomegranate extract does not influence changes in the microcirculation and glycocalyx during acute high-intensity sprint interval cycling-exercise. Although an unexplained rise in blood lactate concentration was observed

Very low volume high-intensity interval exercise is more effective in young than old women

We investigated the acute neuromuscular and stress responses to three different high-intensity interval training sessions in young (age 19.5 +/- 1.3 years) and older (age 65.7 +/- 2.8 years) women. Cycling exercise comprised either 6 x 5 s or 3 x 30 s all-out, or 3 x 60 s submaximal, efforts each performed 5 weeks apart in randomized order. Peak and average power was higher in young than in older women and was largest during the 6 x 5 s strategy in both groups (p < 0.05). The decrease in the ratio of torques evoked by 20 and 100 Hz electrical stimulation, representing low-frequency fatigue, was more evident after the 3 x 30 and 3 x 60 s than the 6 x 5 s bout in both groups and was larger in young than in older women (p < 0.05). Both groups preferred 6 x 5 s cycling for further training. In conclusion, in young women, very low volume (6 x 5 s) all-out exercise induces significant physiological stress and seems to be an effective means of training. For older women, longer exercise sessions (3 x 60 s) are more stressful than shorter ones but are still tolerable psychologically

Intratendinous Air Phenomenon: A New Ultrasound Marker of Tendon Damage?

Purpose: To explore the presence of intratendinous air in physically active males after different types of strenuous physical exercise.Materials and Methods: To detect foci (air bubbles) in the quadriceps femoris tendon (QFT) and the proximal and distal parts of the patellar tendon, ultrasound examination was performed under two conditions: (1) after high-intensity cycling on a cycle ergometer (metabolic); (2) after 200 drop jumps (exercise-induced muscle damage). Based on the results of these two interventions, the presence of air in the tendons after 100 drop jumps was examined further with frequently repeated ultrasound measurements.Results: Foci were detected in exercise-induced muscle damage. Twenty-three of Sixty investigated tendons (38.3%) were observed to contain hyperechoic foci after 100 drop jumps. QFT foci were present in 13/23 cases (56.5%). The location of foci in the QFT was mostly lateral and centro-lateral (76.9%). The foci disappeared completely between 40 and 180 min after completing 100 drop jumps.Conclusions: The presence of intratendinous air seems related to high-magnitude, high-force, high-strain exercise of the particular tendon areas. It might represent the stress response of tendons to overload condition

Skin temperature throughout cold acclimation.

<p>Skin temperature before (A) and after (B) body cooling, and change from before to after body cooling (C). * <i>P</i><0.05, compared with the CA-1. Δ T_sk  =  mean difference between T_sk before and T_sk after cold exposure. Values are means ± SEM.</p