516 research outputs found

    When being wasteful appears better than feeling wasteful

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    "Waste not want not" expresses our culture's aversion to waste. "I could have gotten the same thing for less" is a sentiment that can diminish pleasure in a transaction. We study people's willingness to "pay" to avoid this spoiler. In one scenario, participants imagined they were looking for a rental apartment, and had bought a subscription to an apartment listing. If a cheaper subscription had been declined, respondents preferred not to discover post hoc that it would have sufficed. Specifically, they preferred ending their quest for the ideal apartment after seeing more, rather than fewer, apartments, so that the length of the search exceeds that available within the cheaper subscription. Other scenarios produced similar results. We conclude that people may sometimes prefer to be wasteful in order to avoid feeling wasteful.waste aversion, mental accounting, violation of dominance, counterfactual, regret

    Ancient Urban Ecology Reconstructed from Archaeozoological Remains of Small Mammals in the Near East

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    Acknowledgments We especially thank the many archaeologists who collaborated closely with our project and invested pioneering efforts in intensive fine-scale retrieval of the archaeozoological samples that provided the basis for this study: Shai Bar, Amnon Ben-Tor, Amit Dagan, Yosef Garfinkel, Ayelet Gilboa, Zvi Greenhut, Amihai Mazar, Stefan Munger, Ronny Reich, Itzhaq Shai, Ilan Sharon, Joe Uziel, Sharon Zuckerman, and additional key excavation personnel who were instrumental in collection of the samples or in assisting the work including: Shimrit Bechar, Jacob Dunn, Norma Franklin, Egon Lass and Yiftah Shalev. Funding:The research was funded by a post-doctoral grant awarded to L.W. from the European Research Council under the European Community’s Seventh Framework Program (FP7/2007e2013)/ERC grant agreement number 229418. The laboratory work was also supported by funding by the Israel Science Foundation (Grant 52/10). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

    Biological interaction networks are conserved at the module level

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    <p>Abstract</p> <p>Background</p> <p>Orthologous genes are highly conserved between closely related species and biological systems often utilize the same genes across different organisms. However, while sequence similarity often implies functional similarity, interaction data is not well conserved even for proteins with high sequence similarity. Several recent studies comparing high throughput data including expression, protein-protein, protein-DNA, and genetic interactions between close species show conservation at a much lower rate than expected.</p> <p>Results</p> <p>In this work we collected comprehensive high-throughput interaction datasets for four model organisms (<it>S. cerevisiae, S. pombe, C. elegans</it>, and <it>D. melanogaster</it>) and carried out systematic analyses in order to explain the apparent lower conservation of interaction data when compared to the conservation of sequence data. We first showed that several previously proposed hypotheses only provide a limited explanation for such lower conservation rates. We combined all interaction evidences into an integrated network for each species and identified functional modules from these integrated networks. We then demonstrate that interactions that are part of functional modules are conserved at much higher rates than previous reports in the literature, while interactions that connect between distinct functional modules are conserved at lower rates.</p> <p>Conclusions</p> <p>We show that conservation is maintained between species, but mainly at the module level. Our results indicate that interactions within modules are much more likely to be conserved than interactions between proteins in different modules. This provides a network based explanation to the observed conservation rates that can also help explain why so many biological processes are well conserved despite the lower levels of conservation for the interactions of proteins participating in these processes.</p> <p>Accompanying website: <url>http://www.sb.cs.cmu.edu/CrossSP</url></p
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