Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection

Mucosa-associated lymphoid tissue (MALT) lymphoma is the third most common non-Hodgkin lymphoma, and it is strongly associated with helicobacter pylori infection of the stomach. MALT lymphoma of the lacrimal gland usually presents as a localized disease process in extranodal tissues. The treatment options of MALT lymphoma of the lacrimal gland chiefly include radiation of the tumor, chemotherapy, surgical removal, or a combination of these strategies. We report a case of localized MALT lymphoma of the lacrimal gland, with prolonged sustained remission after eradication of gastric Helicobacter pylori (H. Pylori) infection. He sustains in remission of lacrimal MALT lymphoma for four years without chemotherapy or radiotherapy

Hybrid Workload Enabled and Secure Healthcare Monitoring Sensing Framework in Distributed Fog-Cloud Network

The Internet of Medical Things (IoMT) workflow applications have been rapidly growing in practice. These internet-based applications can run on the distributed healthcare sensing system, which combines mobile computing, edge computing and cloud computing. Offloading and scheduling are the required methods in the distributed network. However, a security issue exists and it is hard to run different types of tasks (e.g., security, delay-sensitive, and delay-tolerant tasks) of IoMT applications on heterogeneous computing nodes. This work proposes a new healthcare architecture for workflow applications based on heterogeneous computing nodes layers: an application layer, management layer, and resource layer. The goal is to minimize the makespan of all applications. Based on these layers, the work proposes a secure offloading-efficient task scheduling (SEOS) algorithm framework, which includes the deadline division method, task sequencing rules, homomorphic security scheme, initial scheduling, and the variable neighbourhood searching method. The performance evaluation results show that the proposed plans outperform all existing baseline approaches for healthcare applications in terms of makespan

Effect of modified 5% sodium fluoride on the surface roughness and hardness of the enamel of primary incisors: An in vitro study

Background: There has been interest over the past decade in the principle that additives that promote the formation of calcium hydroxyapatite can increase the efficacy of sodium fluoride varnishes (NaF). Aim: This study aimed to compare in vitro; the protective effect of a commercially available 5% NaF varnish with the protective effects of 5% NaF varnishes enhanced with functional tricalcium phosphate (fTCP) and amorphous calcium phosphate (ACP). Methodology: A total of 120 primary incisors were divided into four groups of 30 teeth. Group 1 comprised a control group that received no fluoride varnish, Group 2, teeth treated with 5% NaF varnish, Group 3, treated with 5% NaF enhanced with fTCP and Group 4, teeth treated with 5% NaF enhanced with ACP. Surface roughness before and after pH cycling was measured using a profilometer, whereas surface microhardness was measured after pH cycling. Results: Teeth in Group 4 (ACP) and Group 3 (fTCP) showed significantly higher surface microhardness values than the other groups, but there existed a large variation in the range of values obtained. No Significant differences were observed in the change in surface roughness among all groups. Conclusion: The large variation seen in the microhardness values suggest that the effects of the addition of ACP or FTCP to 5% NaF varnish may not be predictable in primary teeth

A rare sporadic case of C3 gene mutation in 5-month-old baby girl with atypical hemolytic uremic syndrome, with good prognosis

Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy representing A, p.(Asp1115Asn). The early recognition and administration of eculizumab are a lifesaving measure. C3 gene mutations are an autosomal dominant inherited pattern, with 50% risk of inheriting this mutation. Therefore, genetic counseling and family member testing are recommended

Structural Homology-Based Drug Repurposing Approach for Targeting NSP12 SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2, also known as SARS-CoV-2, is the causative agent of the COVID-19 global pandemic. SARS-CoV-2 has a highly conserved non-structural protein 12 (NSP-12) involved in RNA-dependent RNA polymerase (RdRp) activity. For the identification of potential inhibitors for NSP-12, computational approaches such as the identification of homologous proteins that have been previously targeted by FDA-approved antivirals can be employed. Herein, homologous proteins of NSP-12 were retrieved from Protein DataBank (PDB) and the evolutionary conserved sequence and structure similarity of the active site of the RdRp domain of NSP-12 was characterized. The identified homologous structures of NSP-12 belonged to four viral families: Coronaviridae, Flaviviridae, Picornaviridae, and Caliciviridae, and shared evolutionary conserved relationships. The multiple sequences and structural alignment of homologous structures showed highly conserved amino acid residues that were located at the active site of the RdRp domain of NSP-12. The conserved active site of the RdRp domain of NSP-12 was evaluated for binding affinity with the FDA-approved antivirals, i.e., Sofosbuvir and Dasabuvir in a molecular docking study. The molecular docking of Sofosbuvir and Dasabuvir with the active site that contains conserved motifs (motif A-G) of the RdRp domain of NSP-12 revealed significant binding affinity. Furthermore, MD simulation also inferred the potency of Sofosbuvir and Dasabuvir. In conclusion, targeting the active site of the RdRp domain of NSP-12 with Dasabuvir and Sofosbuvir might reduce viral replication and pathogenicity and could be further studied for the treatment of SARS-CoV-2