Synthesis of Block Copolymers to Deliver Ortho-Carborane for Proton Capture Therapy

https://openworks.mdanderson.org/sumexp22/1103/thumbnail.jp

Difluoroalkylative carbonylation of alkenes to access carbonyl difluoro-containing heterocycles: convenient synthesis of gemigliptin

Fluorinated heterocycles play a vital role in pharmaceutical and agrochemical industries. Hence, rapid and efficient construction of fluorinated heterocycles remains highly demanded. Herein, a difluoroalkylative carbonylative cyclization of unactivated alkenes and ethylene gas enabled by palladium catalysis has been developed for the first time toward the synthesis of α-carbonyl difluoro-modified glutarimides. This procedure can also be applied to the synthesis of GeMigliptin which is a medicine approved for the treatment of type 2 diabetes mellitus. [Figure not available: see fulltext.

Holographic Storage of Biphoton Entanglement

Coherent and reversible storage of multi-photon entanglement with a multimode quantum memory is essential for scalable all-optical quantum information processing. Although single photon has been successfully stored in different quantum systems, storage of multi-photon entanglement remains challenging because of the critical requirement for coherent control of photonic entanglement source, multimode quantum memory, and quantum interface between them. Here we demonstrate a coherent and reversible storage of biphoton Bell-type entanglement with a holographic multimode atomic-ensemble-based quantum memory. The retrieved biphoton entanglement violates Bell's inequality for 1 microsecond storage time and a memory-process fidelity of 98% is demonstrated by quantum state tomography.Comment: 5 pages, 4 figures, accepted by Phys. Rev. Let

Effects of Vanadium doping on BaFe2As2

We report an investigation of the structural, magnetic and electronic properties of Ba(Fe(1-x)V(x))2As2 using x-ray, transport, magnetic susceptibility and neutron scattering measurements. The vanadium substitutions in Fe sites are possible up to 40\%. Hall effect measurements indicate strong hole-doping effect through V doping, while no superconductivity is observed in all samples down to 2K. The antiferromagnetic and structural transition temperature of BaFe2As2 is gradually suppressed to finite temperature then vanishes at x=0.245 with the emergence of spin glass behavior, suggesting an avoided quantum critical point (QCP). Our results demonstrate that the avoided QCP and spin glass state which were previously reported in the superconducting phase of Co/Ni-doped BaFe2As2 can also be realized in non-superconducting Ba(Fe(1-x)V(x))2As2.Comment: 5 pages, 6 figure

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor

The testicular yolk sac tumor (TYST) is the most common neoplasm originated from germ cells differentiated abnormally, a major part of pediatric malignant testicular tumors. The present study aimed at developing and validating the in vitro and vivo models of TYST and evaluating the sensitivity of TYST to treatments, by cloning human TYST cells and investigating the histology, ultra-structure, growth kinetics and expression of specific proteins of cloned cells. We found biological characteristics of cloned TYST cells were similar to the yolk sac tumor and differentiated from the columnar to glandular-like or goblet cells-like cells. Chromosomes for tumor identification in each passage met nature of the primary tumor. TYST cells were more sensitive to all-trans-retinoic acid which had significantly inhibitory effects on cell proliferation. Cisplatin induced apoptosis of TYST cells through the activation of p53 expression and down-regulation of Bcl- expression. Thus, we believe that cloned TYST cells and the animal model developed here are useful to understand the molecular mechanism of TYST cells and develop potential therapies for human TYST

Research on bulbous bow optimization based on the improved PSO algorithm

On order to reduce the total resistance of a hull, an optimization framework for the bulbous bow optimization was presented. The total resistance in calm water was selected as the objective function, and the overset mesh technique was used for mesh generation. RANS method was used to calculate the total resistance of the hull. In order to improve the efficiency and smoothness of the geometric reconstruction, the arbitrary shape deformation (ASD) technique was introduced to change the shape of the bulbous bow. To improve the global search ability of the particle swarm optimization (PSO) algorithm, an improved particle swarm optimization (IPSO) algorithm was proposed to set up the optimization model. After a series of optimization analyses, the optimal hull form was found. It can be concluded that the simulation based design framework built in this paper is a promising method for bulbous bow optimization

Analysis of fractal characteristic of fragments from rock burst tests under different loading rates

Prsnuće stijene je uobičajena ozbiljna geološka opasnost kod podzemnih tehničkih radova koja uvelike utječe na razvoj projekata. Mehanizam prsnuća stijene može se objasniti zakonom raspodjele komadića stijene i njihovim fraktalnim karakteristikama. Proveden je simulacijski eksperiment rasprsnuća stijene s uzorcima granita pri dvoosnom opterećenju strojnog sustava u analizi fraktalnih karakteristika krhotina rasprsnule stijene. Krhotine granita su sakupljene i metodom selekcije podijeljene u grube, srednje, fine i mikro zrnca. Broj i raspodjela mase krhotina po veličini u različite nizove također su analizirani. Izračunate su fraktalne dimenzije krhotina stijene metodom distribucije mase-zrnatosti. Rezultati pokazuju da je stupanj opterećenja proporcionalan stupnju štete nastale prskanjem stijene; masa ostataka stijene povećava se porastom stupnja opterećenja, što pokazuje da visoki stupanj opterećenja dovodi do znatnog oštećenja stijene. Visoki stupanj opterećenja također rezultira malim količinama finih i srednjih zrna i velikim iznosom grubih zrna, uz zanemarivu promjenu mikro zrna. U uvjetima visokog stupnja opterećenja, fraktalne dimenzije ostataka stijene su male, ali je oslobođena energija rasprsnuća stijene velika. Zaključci dobiveni ovim istraživanjem potvrđuju mogućnost smanjenja rizika rasprsnuća stijene podešavanjem brzine iskapanja kod tehničkih radova i osnova su za daljnja istraživanja mehanizma rasprsnuća stijene.Rock burst is a common serious geological hazard in underground engineering, which seriously affects the progress of projects. The mechanism of rock burst can be explained by the distribution law of rock fragments and its fractal characteristics. A simulation experiment of rock burst was conducted with the granite samples under a biaxial loading machine system to analyze the fractal characteristics of the fragments from rock burst tests. The granite fragments were collected and divided into coarse, medium, fine, and micro grains by a screening method. The number and mass distribution of the fragments in different size ranges were also analyzed. The fractal dimensions of the rock fragments were calculated by the mass-granularity distribution method. Results show that the loading rate is proportional to the damage degree of rock burst; the mass of rock burst debris increases with the increase in loading rate, which indicates that a high loading rate leads to considerable rock damage. A high loading rate also results in small proportions of fine and medium grains and a large proportion of coarse grain, with no significant change in the micro grain. Under the high-loading-rate condition, the fractal dimensions of rock fragments are small, but the released energy of rock burst is large. The conclusions obtained in this study confirm the feasibility of reducing the risk of rock burst by adjusting the excavation rate in engineering practice and provide the basis for further study on the mechanism of rock burst

Influence of stone load on the outcome of same-session flexible ureteroscopy for bilateral upper urinary tract stones: a multicenter retrospective study

PurposeThis study aimed to evaluate the efficacy and safety of same-session flexible ureteroscopy (fURS) for the treatment of bilateral upper urinary tract stones and to examine the influence of stone load on the outcome of same-session fURS, stratifying by total diameter of stones (TDS) ≤30 mm vs. >30 mm.Patients and methodsWe retrospectively reviewed all cases of same-session fURS performed for bilateral upper urinary tract stones at four institutions between January 2017 and September 2020. All patients were divided into two groups based on TDS, ≤30 mm and >30 mm. Data on patient demographics, stone characteristics, surgical results, and complications were collected and analyzed for differences between the two groups. Stone-free rate (SFR) was defined as patients endoscopically stone-free or with radiological fragments <2 mm of each renal unit.ResultsA total of 121 patients with bilateral upper urinary tract stones underwent same-session fURS, consisting of 73 patients in the TDS ≤ 30 mm group and 48 patients in the TDS > 30 mm group. The mean bilateral stone size was 28.2 ± 12.2 mm (range: 9.1–38.4 mm), with a mean operating time of 97.1 ± 39.6 min (range: 19–220 min). The SFR was 54.5% after the first fURS, and SFR increased to 97.5% after re-fURS for residual stones. The operation time for the TDS > 30 mm group was longer than that of the TDS ≤ 30 mm group (85.1 ± 36.5 vs. 115.4 ± 37.4 min, p < 0.001). The SFR after the first fURS was significantly lower in the TDS > 30 mm group than in the TDS ≤ 30 mm group (25.0% vs. 73.9%, p < 0.001). Although there was no statistically significant difference in overall SFR between the two groups (93.7% vs. 100%, p = 0.060), the rate of re-fURS for residual stones was higher in the TDS > 30 mm group than in the TDS ≤ 30 mm group (75% vs. 26%, p < 0.001). There were no significant differences in length of hospital stay (LOS) (2.2 ± 0.7 vs. 2.3 ± 1.0, p = 0.329) or complication rate (10.9% vs. 14.6%, p = 0.582) between the two groups.ConclusionThe results suggested that same-session fURS can be effectively performed with a low complication rate. A higher SFR after the first fURS can be achieved in the case of bilateral upper urinary tract stones with TDS ≤ 30 mm, and priority should be given to same-session fURS