Poly[di-μ4-benzene-1,4-dicarboxyl­ato-μ6-succinato-diholmium(III)]

The title compound, [Ho2(C4H4O4)(C8H4O4)2]n, was synthesized hydro­thermally. The Ho atom is coordinated by four O atoms from four benzene-1,4-dicarboxyl­ate (BDC) anions and four O atoms from three succinate anions, in a distorted square-anti­prismatic coordination geometry. The anti­prisms are bridged by the benzene-1,4-dicarboxyl­ate and succinate anions, into a three-dimensional coordination network. The succinate anions are located on centres of inversion

A Plagiarism Detection Algorithm based on Extended Winnowing

Plagiarism is a common problem faced by academia and education. Mature commercial plagiarism detection system has the advantages of comprehensive and high accuracy, but the expensive detection costs make it unsuitable for real-time, lightweight application environment such as the student assignments plagiarism detection. This paper introduces the method of extending classic Winnowing plagiarism detection algorithm, expands the algorithm in functionality. The extended algorithm can retain the text location and length information in original document while extracting the fingerprints of a document, so that the locating and marking for plagiarism text fragment are much easier to achieve. The experimental results and several years of running practice show that the expansion of the algorithm has little effect on its performance, normal hardware configuration of PC will be able to meet small and medium-sized applications requirements. Based on the characteristics of lightweight, high efficiency, reliability and flexibility of Winnowing, the extended algorithm further enhances the adaptability and extends the application areas

4-(3-Fluoro­phen­yl)-6-hy­droxy-5-(thio­phen-2-ylcarbon­yl)-6-trifluoro­methyl-1,3-diazinan-2-one

In the title compound, C16H12F4N2O3S, the pyrimidine ring adopts a half-chair conformation; the mean plane formed by the ring atoms excluding the C atom bonded to the thio­phen-2-ylcarbonyl group has an r.m.s. deviation of 0.059 Å. The dihedral angle between the benzene and thio­phene rings is 62.26 (7)°. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯O hydrogen bond, generating an S(6) ring. In the crystal, adjacent mol­ecules are connected via a centrosymmetric R 2 2(6) motif, formed by N—H⋯O hydrogen bonds

Video Anomaly Detection by Solving Decoupled Spatio-Temporal Jigsaw Puzzles

Video Anomaly Detection (VAD) is an important topic in computer vision. Motivated by the recent advances in self-supervised learning, this paper addresses VAD by solving an intuitive yet challenging pretext task, i.e., spatio-temporal jigsaw puzzles, which is cast as a multi-label fine-grained classification problem. Our method exhibits several advantages over existing works: 1) the spatio-temporal jigsaw puzzles are decoupled in terms of spatial and temporal dimensions, responsible for capturing highly discriminative appearance and motion features, respectively; 2) full permutations are used to provide abundant jigsaw puzzles covering various difficulty levels, allowing the network to distinguish subtle spatio-temporal differences between normal and abnormal events; and 3) the pretext task is tackled in an end-to-end manner without relying on any pre-trained models. Our method outperforms state-of-the-art counterparts on three public benchmarks. Especially on ShanghaiTech Campus, the result is superior to reconstruction and prediction-based methods by a large margin.Comment: Accepted by ECCV'2022; Code is available at https://github.com/gdwang08/Jigsaw-VA

Unilaterally Aggregated Contrastive Learning with Hierarchical Augmentation for Anomaly Detection

Anomaly detection (AD), aiming to find samples that deviate from the training distribution, is essential in safety-critical applications. Though recent self-supervised learning based attempts achieve promising results by creating virtual outliers, their training objectives are less faithful to AD which requires a concentrated inlier distribution as well as a dispersive outlier distribution. In this paper, we propose Unilaterally Aggregated Contrastive Learning with Hierarchical Augmentation (UniCon-HA), taking into account both the requirements above. Specifically, we explicitly encourage the concentration of inliers and the dispersion of virtual outliers via supervised and unsupervised contrastive losses, respectively. Considering that standard contrastive data augmentation for generating positive views may induce outliers, we additionally introduce a soft mechanism to re-weight each augmented inlier according to its deviation from the inlier distribution, to ensure a purified concentration. Moreover, to prompt a higher concentration, inspired by curriculum learning, we adopt an easy-to-hard hierarchical augmentation strategy and perform contrastive aggregation at different depths of the network based on the strengths of data augmentation. Our method is evaluated under three AD settings including unlabeled one-class, unlabeled multi-class, and labeled multi-class, demonstrating its consistent superiority over other competitors.Comment: Accepted by ICCV'202

Linear Streptomyces plasmids form superhelical circles through interactions between their terminal proteins

Linear chromosomes and linear plasmids of Streptomyces possess covalently bound terminal proteins (TPs) at the 5′ ends of their telomeres. These TPs are proposed to act as primers for DNA synthesis that patches the single-stranded gaps at the 3′ ends during replication. Most (‘archetypal’) Streptomyces TPs (designated Tpg) are highly conserved in size and sequence. In addition, there are a number of atypical TPs with heterologous sequences and sizes, one of which is Tpc that caps SCP1 plasmid of Streptomyces coelicolor. Interactions between the TPs on the linear Streptomyces replicons have been suggested by electrophoretic behaviors of TP-capped DNA and circular genetic maps of Streptomyces chromosomes. Using chemical cross-linking, we demonstrated intramolecular and intermolecular interactions in vivo between Tpgs, between Tpcs and between Tpg and Tpc. Interactions between the chromosomal and plasmid telomeres were also detected in vivo. The intramolecular telomere interactions produced negative superhelicity in the linear DNA, which was relaxed by topoisomerase I. Such intramolecular association between the TPs poses a post-replicational complication in the formation of a pseudo-dimeric structure that requires resolution by exchanging TPs or DNA

Clinical research on liver reserve function by 13C-phenylalanine breath test in aged patients with chronic liver diseases

<p>Abstract</p> <p>Background</p> <p>The objective of this study was to investigate whether the ¹³C-phenylalanine breath test could be useful for the evaluation of hepatic function in elderly volunteers and patients with chronic hepatitis B and liver cirrhosis.</p> <p>Methods</p> <p>L-[1-¹³C] phenylalanine was administered orally at a dose of 100 mg to 55 elderly patients with liver cirrhosis, 30 patients with chronic hepatitis B and 38 elderly healthy subjects. The breath test was performed at 8 different time points (0, 10, 20, 30, 45, 60, 90, 120 min) to obtain the values of Delta over baseline, percentage ¹³CO₂exhalation rate and cumulative excretion (Cum). The relationships of the cumulative excretion with the ¹³C-%dose/h and blood biochemical parameters were investigated.</p> <p>Results</p> <p>The ¹³C-%dose/h at 20 min and 30 min combined with the cumulative excretion at 60 min and 120 min correlated with hepatic function tests, serum albumin, hemoglobin, platelet and Child-Pugh score. Prothrombin time, total and direct bilirubin were significantly increased, while serum albumin, hemoglobin and platelet, the cumulative excretion at 60 min and 120 min values decreased by degrees of intensity of the disease in Child-Pugh A, B, and C patients (P < 0.01).</p> <p>Conclusions</p> <p>The ¹³C-phenylalanine breath test can be used as a non-invasive assay to evaluate hepatic function in elderly patients with liver cirrhosis. The ¹³C-%dose/h at 20 min, at 30 min and cumulative excretion at 60 min may be the key value for determination at a single time-point. ¹³C-phenylalanine breath test is safe and helpful in distinguishing different stages of hepatic dysfunction for elderly cirrhosis patients.</p

Transmission of H7N9 influenza virus in mice by different infective routes.

BackgroundOn 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported in mainland China since then. Laboratory-confirmed, human-to-human H7N9 virus transmission has not been documented between individuals having close contact; however, this transmission route could not be excluded for three families. To control the spread of the avian influenza H7N9 virus, we must better understand its pathogenesis, transmissibility, and transmission routes in mammals. Studies have shown that this particular virus is transmitted by aerosols among ferrets.MethodsTo study potential transmission routes in animals with direct or close contact to other animals, we investigated these factors in a murine model.ResultsViable H7N9 avian influenza virus was detected in the upper and lower respiratory tracts, intestine, and brain of model mice. The virus was transmissible between mice in close contact, with a higher concentration of virus found in pharyngeal and ocular secretions, and feces. All these biological materials were contagious for naïve mice.ConclusionsOur results suggest that the possible transmission routes for the H7N9 influenza virus were through mucosal secretions and feces