16,474 research outputs found
Deduction of the quantum numbers of low-lying states of 6-nucleon systems based on symmetry
The inherent nodal structures of the wavefunctions of 6-nucleon systems have
been investigated. The existence of a group of six low-lying states dominated
by L=0 has been deduced. The spatial symmetries of these six states are found
to be mainly {4,2} and {2,2,2}.Comment: 8 pages, no figure
Improved Simulation of the Mass Charging for ASTROD I
The electrostatic charging of the test mass in ASTROD I (Astrodynamical Space
Test of Relativity using Optical Devices I) mission can affect the quality of
the science data as a result of spurious Coulomb and Lorentz forces. To
estimate the size of the resultant disturbances, credible predictions of
charging rates and the charging noise are required. Using the GEANT4 software
toolkit, we present a detailed Monte Carlo simulation of the ASTROD I test mass
charging due to exposure of the spacecraft to galactic cosmic-ray (GCR) protons
and alpha particles (3He, 4He) in the space environment. A positive charging
rate of 33.3 e+/s at solar minimum is obtained. This figure reduces by 50% at
solar maximum. Based on this charging rate and factoring in the contribution of
minor cosmic-ray components, we calculate the acceleration noise and stiffness
associated with charging. We conclude that the acceleration noise arising from
Coulomb and Lorentz effects are well below the ASTROD I acceleration noise
limit at 0.1 mHz both at solar minimum and maximum. The coherent Fourier
components due to charging are investigated, it needs to be studied carefully
in order to ensure that these do not compromise the quality of science data in
the ASTROD I mission.Comment: 20 pages, 14 figures, submitted to International Journal of Modern
Physics
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Mechanistic Study Of Plasma Damage Of Low k Dielectric Surfaces
Plasma damage to low k dielectric materials was investigated from a mechanistic point of view. Low k dielectric films were treated by plasma Ar, O-2, N-2/H-2, N-2 and H-2 in a standard RIE chamber and the damage was characterized by Angle Resolved X-ray Photoelectron Spectroscopy (ARXPS), X-Ray Reflectivity (XRR), Fourier Transform Infrared Spectroscopy (FTIR) and Contact Angle measurements. Both carbon depletion and surface densification were observed on the top surface of damaged low k materials while the bulk remained largely unaffected. Plasma damage was found to be a complicated phenomenon involving both chemical and physical effects, depending on chemical reactivity and the energy and mass of the plasma species. A downstream hybrid plasma source with separate ions and atomic radicals was employed to study their respective roles in the plasma damage process. Ions were found to play a more important role in the plasma damage process. The dielectric constant of low k materials can increase up to 20% due to plasma damage and we attributed this to the removal of the methyl group making the low k surface hydrophilic. Annealing was generally effective in mitigating moisture uptake to restore the k value but the recovery was less complete for higher energy plasmas. Quantum chemistry calculation confirmed that physisorbed water in low k materials induces the largest increase of dipole moments in comparison with changes of surface bonding configurations, and is primarily responsible for the dielectric constant increase.Microelectronics Research Cente
The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease.
BACKGROUND:
Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia. Alterations in the gut microbiota and/or gut bile acids could account for the increase in this risk. However, no studies have yet investigated the net result of cholestasis and a potentially altered bile acid pool interacting with a dysbiotic gut flora in the inflamed colon of PSC-IBD.
AIM:
The aim of this study was to compare the gut microbiota and stool bile acid profiles, as well as and their correlation in patients with PSC-IBD and inflammatory bowel disease alone.
METHODS:
Thirty patients with extensive colitis (15 with concomitant primary sclerosing cholangitis) were prospectively recruited and fresh stool samples were collected. The microbiota composition in stool was profiled using bacterial 16S rRNA sequencing. Stool bile acids were assessed by high-performance liquid chromatography tandem mass spectrometry.
RESULTS:
The total stool bile acid pool was significantly reduced in PSC-IBD. Although no major differences were observed in the individual bile acid species in stool, their overall combination allowed a good separation between PSC-IBD and inflammatory bowel disease. Compared with inflammatory bowel disease alone, PSC-IBD patients demonstrated a different gut microbiota composition with enrichment in Ruminococcus and Fusobacterium genus compared with inflammatory bowel disease. At the operational taxonomic unit level major shifts were observed within the Firmicutes (73%) and Bacteroidetes phyla (17%). Specific microbiota-bile acid correlations were observed in PSC-IBD, where 12% of the operational taxonomic units strongly correlated with stool bile acids, compared with only 0.4% in non-PSC-IBD.
CONCLUSIONS:
Patients with PSC-IBD had distinct microbiota and microbiota-stool bile acid correlations as compared with inflammatory bowel disease. Whether these changes are associated with, or may predispose to, an increased risk of colorectal neoplasia needs to be further clarified.info:eu-repo/semantics/publishedVersio
Hyperfine Interactions in the Heavy Fermion CeMIn_5 Systems
The CeMIn_5 heavy fermion compounds have attracted enormous interest since
their discovery six years ago. These materials exhibit a rich spectrum of
unusual correlated electron behavior, and may be an ideal model for the high
temperature superconductors. As many of these systems are either
antiferromagnets, or lie close to an antiferromagnetic phase boundary, it is
crucial to understand the behavior of the dynamic and static magnetism. Since
neutron scattering is difficult in these materials, often the primary source of
information about the magnetic fluctuations is Nuclear Magnetic Resonance
(NMR). Therefore, it is crucial to have a detailed understanding of how the
nuclear moments interact with conduction electrons and the local moments
present in these systems. Here we present a detailed analysis of the hyperfine
coupling based on anisotropic hyperfine coupling tensors between nuclear
moments and local moments. Because the couplings are symmetric with respect to
bond axes rather than crystal lattice directions, the nuclear sites can
experience non-vanishing hyperfine fields even in high symmetry sites.Comment: 15 pages, 5 figure
Incommensurate magnetic structure of CeRhIn5
The magnetic structure of the heavy fermion antiferromagnet CeRhIn5 is
determined using neutron diffraction. We find a magnetic wave vector
q_M=(1/2,1/2,0.297), which is temperature independent up to T_N=3.8K. A
staggered moment of 0.374(5) Bohr magneton at 1.4K, residing on the Ce ion,
spirals transversely along the c axis. The nearest neighbor moments on the
tetragonal basal plane are aligned antiferromagnetically.Comment: 4 pages, 4 figures There was an extra factor of 2 in Eq (2). This
affects the value of staggered moment. The correct staggered moment is
0.374(5) Bohr magneton at 1.4
Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?
Sepsis refers to a systemic inflammatory response syndrome resulting from microbial infections, and is partly attributable to dysregulated inflammation and associated immunosuppression. A ubiquitous nuclear protein, HMGB1, is secreted by activated leukocytes to orchestrate inflammatory responses during early stages of sepsis. When it is released by injured somatic cells at overwhelmingly higher quantities, HMGB1 may induce macrophage pyroptosis and immunosuppression, thereby impairing the host\u27s ability to eradicate microbial infections. A number of endogenous proteins have been shown to bind HMGB1 to modulate its extracellular functions. Here, we discuss an emerging possibility to develop therapeutic antibodies against harmless proteins that collude with pathogenic mediators for the clinical management of human sepsis and other inflammatory diseases
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