16,405 research outputs found

    Deduction of the quantum numbers of low-lying states of 6-nucleon systems based on symmetry

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    The inherent nodal structures of the wavefunctions of 6-nucleon systems have been investigated. The existence of a group of six low-lying states dominated by L=0 has been deduced. The spatial symmetries of these six states are found to be mainly {4,2} and {2,2,2}.Comment: 8 pages, no figure

    Improved Simulation of the Mass Charging for ASTROD I

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    The electrostatic charging of the test mass in ASTROD I (Astrodynamical Space Test of Relativity using Optical Devices I) mission can affect the quality of the science data as a result of spurious Coulomb and Lorentz forces. To estimate the size of the resultant disturbances, credible predictions of charging rates and the charging noise are required. Using the GEANT4 software toolkit, we present a detailed Monte Carlo simulation of the ASTROD I test mass charging due to exposure of the spacecraft to galactic cosmic-ray (GCR) protons and alpha particles (3He, 4He) in the space environment. A positive charging rate of 33.3 e+/s at solar minimum is obtained. This figure reduces by 50% at solar maximum. Based on this charging rate and factoring in the contribution of minor cosmic-ray components, we calculate the acceleration noise and stiffness associated with charging. We conclude that the acceleration noise arising from Coulomb and Lorentz effects are well below the ASTROD I acceleration noise limit at 0.1 mHz both at solar minimum and maximum. The coherent Fourier components due to charging are investigated, it needs to be studied carefully in order to ensure that these do not compromise the quality of science data in the ASTROD I mission.Comment: 20 pages, 14 figures, submitted to International Journal of Modern Physics

    The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease.

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    BACKGROUND: Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia. Alterations in the gut microbiota and/or gut bile acids could account for the increase in this risk. However, no studies have yet investigated the net result of cholestasis and a potentially altered bile acid pool interacting with a dysbiotic gut flora in the inflamed colon of PSC-IBD. AIM: The aim of this study was to compare the gut microbiota and stool bile acid profiles, as well as and their correlation in patients with PSC-IBD and inflammatory bowel disease alone. METHODS: Thirty patients with extensive colitis (15 with concomitant primary sclerosing cholangitis) were prospectively recruited and fresh stool samples were collected. The microbiota composition in stool was profiled using bacterial 16S rRNA sequencing. Stool bile acids were assessed by high-performance liquid chromatography tandem mass spectrometry. RESULTS: The total stool bile acid pool was significantly reduced in PSC-IBD. Although no major differences were observed in the individual bile acid species in stool, their overall combination allowed a good separation between PSC-IBD and inflammatory bowel disease. Compared with inflammatory bowel disease alone, PSC-IBD patients demonstrated a different gut microbiota composition with enrichment in Ruminococcus and Fusobacterium genus compared with inflammatory bowel disease. At the operational taxonomic unit level major shifts were observed within the Firmicutes (73%) and Bacteroidetes phyla (17%). Specific microbiota-bile acid correlations were observed in PSC-IBD, where 12% of the operational taxonomic units strongly correlated with stool bile acids, compared with only 0.4% in non-PSC-IBD. CONCLUSIONS: Patients with PSC-IBD had distinct microbiota and microbiota-stool bile acid correlations as compared with inflammatory bowel disease. Whether these changes are associated with, or may predispose to, an increased risk of colorectal neoplasia needs to be further clarified.info:eu-repo/semantics/publishedVersio

    Hyperfine Interactions in the Heavy Fermion CeMIn_5 Systems

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    The CeMIn_5 heavy fermion compounds have attracted enormous interest since their discovery six years ago. These materials exhibit a rich spectrum of unusual correlated electron behavior, and may be an ideal model for the high temperature superconductors. As many of these systems are either antiferromagnets, or lie close to an antiferromagnetic phase boundary, it is crucial to understand the behavior of the dynamic and static magnetism. Since neutron scattering is difficult in these materials, often the primary source of information about the magnetic fluctuations is Nuclear Magnetic Resonance (NMR). Therefore, it is crucial to have a detailed understanding of how the nuclear moments interact with conduction electrons and the local moments present in these systems. Here we present a detailed analysis of the hyperfine coupling based on anisotropic hyperfine coupling tensors between nuclear moments and local moments. Because the couplings are symmetric with respect to bond axes rather than crystal lattice directions, the nuclear sites can experience non-vanishing hyperfine fields even in high symmetry sites.Comment: 15 pages, 5 figure

    Incommensurate magnetic structure of CeRhIn5

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    The magnetic structure of the heavy fermion antiferromagnet CeRhIn5 is determined using neutron diffraction. We find a magnetic wave vector q_M=(1/2,1/2,0.297), which is temperature independent up to T_N=3.8K. A staggered moment of 0.374(5) Bohr magneton at 1.4K, residing on the Ce ion, spirals transversely along the c axis. The nearest neighbor moments on the tetragonal basal plane are aligned antiferromagnetically.Comment: 4 pages, 4 figures There was an extra factor of 2 in Eq (2). This affects the value of staggered moment. The correct staggered moment is 0.374(5) Bohr magneton at 1.4

    Time to Develop Therapeutic Antibodies Against Harmless Proteins Colluding with Sepsis Mediators?

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    Sepsis refers to a systemic inflammatory response syndrome resulting from microbial infections, and is partly attributable to dysregulated inflammation and associated immunosuppression. A ubiquitous nuclear protein, HMGB1, is secreted by activated leukocytes to orchestrate inflammatory responses during early stages of sepsis. When it is released by injured somatic cells at overwhelmingly higher quantities, HMGB1 may induce macrophage pyroptosis and immunosuppression, thereby impairing the host\u27s ability to eradicate microbial infections. A number of endogenous proteins have been shown to bind HMGB1 to modulate its extracellular functions. Here, we discuss an emerging possibility to develop therapeutic antibodies against harmless proteins that collude with pathogenic mediators for the clinical management of human sepsis and other inflammatory diseases
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