95 research outputs found
The Iowa AEA Middle School Science Project - Sleds
A resource of over 300 science activities is now available to Iowa science teachers from the Iowa AEA Middle School Science Project electronic bulletin board. It is the result of a report from a 1984 task force commissioned by the Iowa Department of Education to assess the needs of science education in Iowa. The task force identified the grades four through nine as those with the greatest need. Specifically identified was a need for user-friendly teaching materials that emphasized a hands-on/minds-on approach to science. Too large a portion of the science taught in these grades was based primarily on a text book, the task force believed. A corresponding specific need was for teacher inservice emphasizing the \u27\u27hands-on/minds-on approach to science teaching. In addition, the task force identified a need to include more emphasis on technology in the science program
VTE and anticoagulation in menstruating women
Women of childbearing potential have a high prevalence of venous thromboembolism (VTE) due to high estrogen states, such as pregnancy and the use of estrogen-containing contraceptives. Abnormal uterine bleeding (AUB) affects up to two-thirds of menstruating women on anticoagulation (AC), and can severely impair a woman\u27s quality of life. Rates of heavy menstrual bleeding (HMB) and other forms of AUB including inter-menstrual and postmenopausal bleeding are consistently underreported in the original clinical trials utilizing AC. VTE can occur at any time in a woman\u27s life, and the aim of this review article is to discuss the current landscape of literature on AUB for women on AC, VTE and AC in women of child bearing potential, planning for pregnancy while on AC, VTE during pregnancy, and considerations for VTE risk in postmenopausal women. This survey of the current literature may offer data for providers to consider while making clinical decisions on the duration of and appropriate choice of anticoagulation
Extension of the LDA-1/2 method to the material class of bismuth containing III-V semiconductors
The LDA-1/2 method is employed in density functional theory calculations for
the electronic structure of III-V dilute bismide systems. For the
representative example of Ga(SbBi) with Bi concentrations below , it is
shown that this method works very efficiently, especially due to its reasonably
low demand on computer memory. The resulting bandstructure and wavefunctions
are used to compute the interaction matrix elements that serve as input to
microscopic calculations of the optical properties and intrinsic losses
relevant for optoelectronic applications of dilute bismides
Factor VIII: Long-established role in haemophilia A and emerging evidence beyond haemostasis
Abstract Factor VIII protein (FVIII) as a coagulation replacement factor has for decades been used as the standard of care for management of people with haemophilia A. It is effective for treatment of bleeding events, as prophylaxis to prevent bleeding events and preserve joint function, and to support surgery in people with haemophilia A. Despite long experience in treating haemophilia A, we are only beginning to understand the functions of FVIII beyond its established role as a coenzyme to factor IXa to expedite thrombin generation through the intrinsic pathway of coagulation. Here, we review the current role of FVIII coagulant (FVIII:C) in haemophilia A management and emerging evidence for the role of FVIII across multiple systems, including the cardiovascular system, angiogenesis and maintenance of bone health. For instance, supraphysiological FVIII levels are a risk factor for venous thromboembolism. von Willebrand factor (VWF), which forms a non-covalent complex with circulating FVIII, is an established marker and regulator of angiogenesis. In a mouse model of haemophilia, treatment with FVIII decreased expression of receptor activator of nuclear factor kappa-Β ligand (RANKL), a marker for bone turnover. Longitudinal follow-up data in people with haemophilia A are needed to confirm and extend these observations
Management of anticoagulation for cancer-associated thrombosis in patients with thrombocytopenia: A systematic review
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