Precise timing of expression of a Plasmodium falciparum derived transgene in P. berghei is a critical determinant of subsequent subcellular localization.

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Proteases in host cell invasion by the malaria parasite.

The life cycle of the malaria parasite contains three distinct invasive forms, or zoites. For at least two of these--the sporozoite and the blood-stage merozoite--invasion into their respective host cell requires the activity of parasite proteases. This review summarizes the evidence for this, discusses selected well-described proteolytic modifications linked to invasion, and describes recent progress towards identifying the proteases involved