156 research outputs found

    The celebrity entrepreneur on television: profile, politics and power

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    This article examines the rise of the ‘celebrity entrepreneur’ on television through the emergence of the ‘business entertainment format’ and considers the ways in which regular television exposure can be converted into political influence. Within television studies there has been a preoccupation in recent years with how lifestyle and reality formats work to transform ‘ordinary’ people into celebrities. As a result, the contribution of vocationally skilled business professionals to factual entertainment programming has gone almost unnoticed. This article draws on interviews with key media industry professionals and begins by looking at the construction of entrepreneurs as different types of television personalities and how discourses of work, skill and knowledge function in business shows. It then outlines how entrepreneurs can utilize their newly acquired televisual skills to cultivate a wider media profile and secure various forms of political access and influence. Integral to this is the centrality of public relations and media management agencies in shaping media discourses and developing the individual as a ‘brand identity’ that can be used to endorse a range of products or ideas. This has led to policy makers and politicians attempting to mobilize the media profile of celebrity entrepreneurs to reach out and connect with the public on business and enterprise-related issues

    FMR1 Genotype with Autoimmunity-Associated Polycystic Ovary-Like Phenotype and Decreased Pregnancy Chance

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    The FMR1 gene partially appears to control ovarian reserve, with a specific ovarian sub-genotype statistically associated with a polycystic ovary (PCO)- like phenotype. Some forms of PCO have been associated with autoimmunity. We, therefore, investigated in multiple regression analyses associations of ovary-specific FMR1 genotypes with autoimmunity and pregnancy chances (with in vitro fertilization, IVF) in 339 consecutive infertile women (455 IVF cycles), 75 with PCO-like phenotype, adjusted for age, race/ethnicity, medication dosage and number of oocytes retrieved. Patients included 183 (54.0%) with normal (norm) and 156 (46%) with heterozygous (het) FMR1 genotypes; 133 (39.2%) demonstrated laboratory evidence of autoimmunity: 51.1% of het-norm/low, 38.3% of norm and 24.2% het-norm/high genotype and sub-genotypes demonstrated autoimmunity (p = 0.003). Prevalence of autoimmunity increased further in PCO-like phenotype patients with het-norm/low genotype (83.3%), remained unchanged with norm (34.0%) and decreased in het-norm/high women (10.0%; P<0.0001). Pregnancy rates were significantly higher with norm (38.6%) than het-norm/low (22.2%, p = 0.001). FMR1 sub-genotype het-norm/low is strongly associated with autoimmunity and decreased pregnancy chances in IVF, reaffirming the importance of the distal long arm of the X chromosome (FMR1 maps at Xq27.3) for autoimmunity, ovarian function and, likely, pregnancy chance with IVF

    Predictions not commands: active inference in the motor system

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    Comparación de hallazgos histeroscópicos vs. histerosalpingográficos en pacientes sometidas a tratamiento de fertilidad

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    Objetivo: Comparar los hallazgos histeroscópicos vs histerosalpingográficos en pacientes sometidas a tratamiento de fertilidad. Métodos: Estudio observacional, descriptivo, retrospectivo para determinar las causas de infertilidad, y analítico para evaluar la correspondencia de los hallazgos entre la histerosalpingografía y la histeroscopía de mujeres que asistieron a la consulta de fertilidad de la Clínica Leopoldo Aguerrevere, entre enero de 2018 y mayo de 2022. Resultados: Las causas de infertilidad más frecuentes fueron la edad (52,6 %), el factor tubárico (12,4 %) y la falla ovárica precoz (11,7 %); 47,4 % presentaban dos causas de infertilidad, 44,5 % solo una y 8,1 % tres causas. La fertilización in vitro (50,4 %) fue el tratamiento más utilizado para lograr el embarazo. En la histerosalpingografía se reportaron 67,9 % pacientes normales, del total de pólipos reportados, 5,1 % presentaron un pólipo y 4,4 % dos pólipos. En la histeroscopía se reportaron 46 % pacientes normales, del total de pólipos, 30,7 % presentó un pólipo, 4,4 % dos y 0,7 % tres pólipos. Entre los hallazgos más comunes hubo discordancia entre la histerosalpingografía e histeroscopía, siendo las coincidencias menores al 50 %. El índice Kappa, indicó que la correspondencia entre ambos estudios fue baja. Conclusiones: La histeroscopía es una técnica necesaria para el estudio de los trastornos endouterinos en mujeres infértiles, aportando información sobre lesiones endocavitarias uterinas, que pueden no ser apreciados con la histerosalpingografía, esta última puede emplearse para diagnóstico presuntivo de patología endometrial y evaluación de la permeabilidad de las trompas de Falopio. Objective: To compare hysteroscopic vs. hysterosalpingographic findings in female patients subject fertility treatment. Methods: Observational, descriptive, retrospective study to determine the causes of infertility, and analytical to evaluate thecorrespondence of the findings between hysterosalpingography and hysteroscopy of women who attended the fertility clinic of the Leopoldo Aguerrevere Clinic between January 2018 and May of 2022. Results: The most frequent causes of infertility were age (52.6%), tubal factor (12.4%) and early ovarian failure (11.7%); 47.4% had two causes of infertility, 44.5% only one and 8.1% three causes. In vitro fertilization (50.4%) was the most commonly used treatment to achieve pregnancy. In hysterosalpingography, 67.9 % normal patients were reported, of the total polyps reported, 5.1 % had one polyp and 4.4 % two polyps. In hysteroscopy, 46 % normal patients were reported, ofthe total polyps, 30.7 % presented one polyp, 4.4 % two and 0.7 % three polyps. Among the most common findings there was discordance between hysterosalpingography and hysteroscopy, with coincidences being less than 50%. The Kappa index indicated that the correspondence between the two studies was low. Conclusions: hysteroscopy is a necessary technique for the study of endouterine disorders in infertile women, providing information on uterine endocavitary lesions, which may not be appreciated with hysterosalpingography, the latter can be used for presumptive diagnosis of endometrial pathology and evaluation of permeability of the fallopian tubes
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