Supplementary data for the article: Ilić, I.; Milutinović-Nikolić, A.; Mojović, Z.; Vuković, Z.; Vulić, P.; Gržetić, I.; Banković, P.; Jović-Jovičić, N. Oxidative Degradation of Aromatic N-Compounds Using Cobalt Containing Montmorillonite-Based Catalysts. Applied Clay Science 2020, 193, 105668. https://doi.org/10.1016/j.clay.2020.105668

Supplementary material for: [https://doi.org/10.1016/j.clay.2020.105668]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/4045

Positrons in gas filled traps and their transport in molecular gases

In this paper we give a review of two recent developments in positron transport, calculation of transport coefficients for a relatively complete set of collision cross sections for water vapour and for application of they Monte Carlo technique to model gas filled subexcitation positron traps such as Penning Malmberg Surko (Surko) trap. Calculated transport coefficients, very much like those for argon and other molecular gases show several new kinetic phenomena. The most important is the negative differential conductivity (NDC) for the bulk drift velocity when the flux drift velocity shows no sign of NDC. These results in water vapour are similar to the results in argon or hydrogen. The same technique that has been used for positron (and previously electron) transport may be applied to model development of particles in a Surko trap. We have provided calculation of the ensemble of positrons in the trap from an initial beam like distribution to the fully thermalised distribution. This model, however, does not include plasma effects (interaction between charged particles) and may be applied for lower positron densities

Stereospecific ligands and their complexes. part viii. antimicrobial activity of palladium(ii) complexes with O,O'-dialkyl esters of (s,s)-ethylenediamine-n,n'-di-2-(4-methyl)-pentanoic acid

Palladium(II) complexes (1-4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N'- -ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine- N,N'-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/Vis spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 μg cm-3 to > 5000 μg cm-3 while MMC values ranged from 78 μg cm-3 to > 5000 μg cm-3. Palladium(II) complexes [PdCl2(Ln)] (n, 1-4) have statistically significant higher activity than the corresponding ligands. Complex 4 displayed the strongest activity among all tested compounds

On diffusion of positrons in electric and magnetic fields in molecular gases

Diagonal elements of the diffusion tensor for positron swarms in molecular gases under the influence of electric and magnetic fields are investigated using a Monte Carlo simulation technique and multi-term theory for solving the Boltzmann equation. The focus was on the synergetic effects of non-conservative collisions and magnetic fields on\ud the diffusion of positrons. It is found that different diagonal elements of the diffusion tensor show different sensitivities to the strength of magnetic field and on the presence of non-conservative collisions

Transport coefficients for positron swarms in molecular gases

[Extract] Transport of positrons in various environments is interesting from many points of view [1]. They are standing behind the origin of astrophysical sources of annihilation radiation; they play a crucial role in production and detection of cold anti-hydrogen and also in the production of positronium (Ps). Recent investigations of positrons have triggered a whole new interesting research area – ionized gases with positrons that may be analyzed using similar techniques albeit for their short lifetime and even the antimatter plasmas. In addition, positrons have been already used for characterization of materials. However, perhaps the most important applications of positrons from the viewpoint of transport studies are the positron buffer-gas traps, such as the Surko trap, and also the use of positrons in the medical diagnostics of positron emission\ud tomography (PET) and possible cancer treatments. Thanks to the recent advances in experimental measurements of high-resolution, low-energy inelastic positron scattering cross sections [2], the determination of positron transport coefficients over a wide range of energies has become possible. These measurements confirm that Ps formation, a non-conservative process unique to positrons, has a much larger cross section than annihilation and the analogous loss process for electrons- the dissociative attachment. This fact, coupled with a very strong energy dependence\ud for Ps formation, is expected to lead to kinetic effects [3]

Potential of the dual mTOR kinase inhibitor AZD2014 to overcome paclitaxel resistance in anaplastic thyroid carcinoma

Purpose: Anaplastic thyroid carcinoma (ATC) is an aggressive, chemo-resistant malignancy. Chemo-resistance is often associated with changes in activity of the RAS/MAPK/ERK and PI3K/AKT/mTOR pathways and/or a high expression of ATP binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). To assess the therapeutic efficacy in ATC of a combination of the dual mTOR kinase inhibitor vistusertib (AZD2014) and paclitaxel (PTX), we generated a new cell line (Rho-) via the selection of human thyroid carcinoma 8505C cells that exhibit a low accumulation of rhodamine 123, which serves as a P-gp and BCRP substrate. Methods: Immunohistochemistry was used for P-gp and BCRP expression analyses in primary ATC patient samples. Spheroid formation and immunodeficient NSG mice were used for performing in vitro and in vivo tumorigenicity assays, respectively. MTT, flow-cytometry, fluorescent microscopy, cell death and proliferation assays, as well as migration, invasion and gelatin degradation assays, were used to assess the potential of AZD2014 to enhance the effects of PTX. ATC xenografts in SCID mice were used for evaluating in vivo treatment efficacies. Results: Rho- cells were found to be 10-fold more resistant to PTX than 8505C cells and, in addition, to be more tumorigenic. We also found that AZD2014 sensitized Rho- cells to PTX by inhibiting proliferation and by inducing autophagy. The combined use of AZD2014 and PTX efficiently inhibited in vitro ATC cell migration and invasion. Subsequent in vivo xenograft studies indicated that the AZD2014 and PTX combination effectively suppressed ATC tumor growth. Conclusions: Our data support results from recent phase I clinical trials using combinations of AZD2014 and PTX for the treatment of solid tumors. Such combinations may also be employed for the design of novel targeted ATC treatment strategies. © 2018, International Society for Cellular Oncology

Chronic hepatitis C: Conspectus of immunological events in the course of fibrosis evolution

© 2019 Baskic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In chronically infected HCV patients emergence and evolution of fibrosis, as a consequence of virus persistence, can be considered as an indicator of disease advancement. Therefore the aim of this study was to correlate alterations of immune response in chronic HCV patients with liver histopathology. Sera cytokine levels and frequency of circulating and liver infiltrating cells were evaluated using 13plex Kit Flow Cytomix, flow cytometry and immuno-histochemistry. We found that the number of circulating T lymphocytes (including CD4+, CD8+ and Treg) and B lymphocytes, as well as DCs, was higher in patients with no fibrosis than in healthy subjects. In patients with fibrosis frequency of these cells decreased, and contrarily, in the liver, number of T and B lymphocytes gradually increased with fibrosis. Importantly, in patients with advanced fibrosis, liver infiltrating regulatory T cells and DC-SIGN+ mononuclear cells with immunosuppressive and wound-healing effector functions were abundantly present. Cytokine profiling showed predominance of proinflammatory cytokines in patients with no fibrosis and a tendency of decline in level of all cytokines with severity of liver injury. Lower but sustained IL-4 production refers to Th2 predominance in higher stages of fibrosis. Altogether, our results reveal graduall alterations of immunological parameters during fibrosis evolution and illustrate the course of immunological events through disease progression

Modified bentonite as adsorbent and catalyst for purification of wastewaters containing dyes

Modification and characterization of bentonite from location Bogovina, Serbia was performed in order to obtain material applicable in wastewater purification. The <75μm bentonite fraction was used in organobentonite synthesis while the <2μm bentonite fraction, obtained by hydroseparation was used in pillaring procedure. Organo-modification of bentonite was performed with (1-hexadecyl)trimethylammonium bromide (HDTMA-Br). Pillared bentonite was obtained using standard procedure. Al3+ and Fe3+ ions were incorporated in pillars in 4:1 ratio and applied as catalyst in catalytic wet peroxide oxidation. Differences in structure of starting and modified bentonites were established by XRD analysis and nitrogen physisorption on -196 °C. The (001) smectite peak around 2θ = 6° shifts during the modification process. The Na-exchange process lowered d001 from 1.53 nm (2θ = 5.78°) for starting clay to 1.28 nm (2θ = 6.92°), but the clay retained its swelling properties. The pillaring process increased and fixed the basal spacing to 1.74 nm. Intercalation of HDTMA ions into smectite structure increased d001 to 2.00 nm for organobentonite. Specific surface area, SBET, was affected by particle size and type of modification. The samples with finer bentonite fraction had higher SBET due to increased smectite content. Na-exchanged bentonite samples had higher SBET value than starting clay samples of same granulation. Organomodification caused dramatic decrease in SBET value, while the pillaring process lead to an increase of SBET value. Adsorptive and catalytic purification of wastewaters containing dyes was tested using Acid Yellow 99 as a model dye. Na-exchanged bentonite had greater adsorption affinity for dye adsorption than raw bentonite owing to higher SBET. By organomodification this affinity was enhanced more than 70 times due to transition of bentonite surface from hydrophilic to organophilic. Al,Fe pillared bentonite was proven to be efficient in catalytic wet peroxide oxidation of Acid Yellow 99 dye at room temperature

NK-lysin Derived Peptide (NK-2) Sensitizes Resistant Cancer Cells to Classic Chemotherapeutics by Selective Killing of P-glycoprotein Over-expressing Cells

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