Possible detection of interstellar glycine in the hot molecular core G10.47+0.03

Amino acids are the essential keys in chemistry that contribute to the study of the formation of life. The complex organic molecule glycine (NH$_{2}$CH$_{2}$COOH) is the simplest amino acid that has been investigated in the interstellar medium for a long period to search for a potential connection between the Universe and the origin of life. In the last forty years, several attempts have failed to detect the interstellar glycine in the hot molecular cores and star-forming regions. We report the possible detection of the rotational emission lines of interstellar glycine with conformer I and II in the hot molecular core G10.47+0.03 between the frequency range of $\nu$ = 158.6$-$160.4 GHz with Atacama Large Millimeter/Submillimeter Array (ALMA) observation. Under the Local Thermodynamic Equilibrium (LTE) condition, we apply the rotational diagram method to estimate the column density ($N$) and rotational temperature ($T_{rot}$) of the detected amino acid glycine. Using rotational diagram, we find the column density of glycine $N$(NH$_{2}$CH$_{2}$COOH) = 2.8$\times$10$^{18}$ cm$^{-2}$ with rotational temperature $T_{rot}$ = 115.9 K. We also apply the Levenberg$-$Marquardt algorithm to extract the line parameters of detected emission lines of glycine.Comment: Comments are welcom

NOVEL CHRONOTHERAPEUTIC MULTIPARTICULATE DRUG DELIVERY SYSTEM OF FELODIPINE: AN EFFECTIVE TREATMENT FOR CARDIAC ARRHYTHMIA

Arrhythmia follows chronobiology, thus necessitating development of time-dependent formulation for its treatment. The aim of the current work was to develop a solubility-enhanced chronotherapeutic system of felodipine, a widely prescribed anti-arrhythmic. Systematically optimized hot-melt extrusion process was employed to formulate solubility-enhanced extrudates. Film-casting method was adopted for the selection of polymers. Drug released at 5, 15, 30min was taken as response variables in 32 face-centered cube design. Nearly 10-fold increase was observed in the solubility of the optimized extrudates in comparison to pure drug. Physical characterization of the extrudates depicted complete amorphization of drug. Sequential coating was performed on to the extrudates to enable a time-dependent release. In-vitro studies clearly demonstrated that 25% of drug was available rapidly within 10 min of administration. The remaining 75% of drug was available over a period of 4, 8 and 12h. Stability studies performed for 6 months at accelerated conditions depicted no significant change in the physicochemical characteristics of the optimized formulation. In-vivo pharmacokinetic studies conducted in beagle dogs ratified the results of in-vitro studies where a sequential time dependent absorption of felodipine was observed over a period of 12h. Concisely, the studies demonstrated successful development of solubility-enhanced chronotherapeutic system of felodipine

One-Loop Quantum Effects in Carroll Scalars

Carrollian field theories at the classical level possess infinite number of space-time symmetries, namely the supertranslations. In this article we enquire whether these symmetries for interacting Carrollian scalar field theory survive in presence of quantum effects. For interactions polynomial in the field, the answer is in the affirmative. We also studied a renormalization group flow particularly tailored to respect the manifest Carroll invariance and analyzed the consequences of introducing Carroll-breaking deformations. The renormalization group flow, with perturbative loop level effects taken into account, indicates a new fixed point apart from the Gaussian ones

Unlocking the potential of Lion’s Mane Mushroom (Hericium erinaceus)

The Lion's Mane mushroom, botanically known as Hericium erinaceus, stands out as a unique and esteemed member of the fungal kingdom. This extraordinary mushroom not only possesses an alluring appearance but also holds a significant historical presence in diverse cultures, especially within the context of ancient herbal medicine practices. This fungus holds promising prospects in several domains. Its potential as a natural remedy for cognitive health is gaining attention. This mushroom has neuroprotective properties and could play a role in supporting brain function, which is particularly relevant in the present aging population where neurodegenerative conditions like Alzheimer's disease are a growing concern. Furthermore, Lion's Mane has been explored for its potential in addressing mood disorders. It is a rich source of bioactive compounds, including β-glucans, that can positively affect the immune system. The fungus produces bioactive compounds that can be used to treat various chronic diseases like obesity, high blood pressure, hepatic disorders, and cancer ; it also has other benefits like wound healing and improving the immune system. This review endeavours to elucidate the multifaceted potential of Lion's Mane mushroom within the domains of nutrition, health, and wellness. Through a comprehensive examination of its properties and benefits, the review explored how Lion's Mane mushrooms can be harnessed to enhance human well-being. By unlocking the secrets hidden within this remarkable fungus, the study provides insights that can empower individuals to incorporate Lion's Mane into their daily lives, fostering a healthier and more balanced lifestyle.

CRISPR- Cas9 Technology: Mechanism and Its Application in The Field of Entomology

The field of life science research has undergone a revolution thanks to the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and CRISPR-associated protein (CRISPR/Cas) system, which provides a multitude of opportunities for modifying, identifying, visualising, and annotating particular DNA or RNA sequences in diverse organisms. In this technique, foreign DNA pieces, known as spacers, are inserted into CRISPR cassettes. These spacers are then transcribed into CRISPR arrays and processed to produce guide RNA (gRNA). The Cas proteins that the CRISPR arrays encode serve as the enzymatic machinery required to obtain new spacers that specifically target invasive genetic elements. Several Cas proteins, such as Cas9, Cas12, Cas13, and Cas14, have been used to create novel tools for genome engineering due to their programmable sequence specificity. The ability to manipulate and edit nucleic acid sequences in living cells from a wide variety of organisms has been made possible by these Cas variants, which have greatly advanced genetic research and the CRISPR/Cas tool. The CRISPR Cas-9 technology has applications in many areas of entomology, including the genetics of honeybees and plants that produce insecticidal compounds. CRISPR/Cas9 technology has transformed entomology by providing precise tools for gene editing and genetic manipulation in insects. This has enabled advancements in fundamental research, disease vector control, and pest management, with the potential to reduce the environmental and economic impact of insect pests in agriculture and public health