Troponins, Acute Coronary Syndrome and Renal Disease: From Acute Kidney Injury Through End-stage Kidney Disease

The diagnosis of acute coronary syndromes (ACS) is heavily dependent on cardiac biomarker assays, particularly cardiac troponins. ACS, particularly non-ST segment elevation MI, are more common in patients with acute kidney injury, chronic kidney disease (CKD) and end-stage kidney disease (ESKD), are associated with worse outcomes than in patients without kidney disease and are often difficult to diagnose and treat. Hence, early accurate diagnosis of ACS in kidney disease patients is important using easily available tools, such as cardiac troponins. However, the diagnostic reliability of cardiac troponins has been suboptimal in patients with kidney disease due to possible decreased clearance of troponin with acute and chronic kidney impairment and low levels of troponin secretion due to concomitant cardiac muscle injury related to left ventricular hypertrophy, inflammation and fibrosis. This article reviews the metabolism and utility of cardiac biomarkers in patients with acute and chronic kidney diseases. Cardiac troponins are small peptides that accumulate in both acute and chronic kidney diseases due to impaired excretion. Hence, troponin concentrations rise and fall with acute kidney injury and its recovery, limiting their use in the diagnosis of ACS. Troponin concentrations are chronically elevated in CKD and ESKD, are associated with poor prognosis and decrease the sensitivity and specificity for diagnosis of ACS. Yet, the evidence indicates that the use of high-sensitivity troponins can confirm or exclude a diagnosis of ACS in the emergency room in a significant proportion of kidney disease patients; those patients in whom the results are equivocal may need longer in-hospital assessment

Connecting anomaly and tunneling methods for Hawking effect through chirality

The role of chirality is discussed in unifying the anomaly and the tunneling formalisms for deriving the Hawking effect. Using the chirality condition and starting from the familiar form of the trace anomaly, the chiral (gravitational) anomaly, manifested as a nonconservation of the stress tensor, near the horizon of a black hole, is derived. Solution of this equation yields the stress tensor whose asymptotic infinity limit gives the Hawking flux. Finally, use of the same chirality condition in the tunneling formalism gives the Hawking temperature that is compatible with the flux obtained by anomaly method.Comment: LaTex, 8 pages, no figures, reformulation of tunneling mechanism, to appear in Phys. Rev.

Artificial Life in an Exciton-Polariton Lattice

We show theoretically that a lattice of exciton-polaritons can behave as a life-like cellular automaton when simultaneously excited by a continuous wave coherent field and a time-periodic sequence of non-resonant pulses. This provides a mechanism of realizing a range of highly sought spatiotemporal structures under the same conditions, including: discrete solitons, oscillating solitons, rotating solitons, breathers, soliton trains, guns, and choatic behaviour. These structures can survive in the system indefinitely, despite the presence of dissipation, and allow universal computation.Comment: 14 pages, 14 figure

Screening in three-dimensional QED with arbitrary fermion mass

We compute the quark--antiquark potential in three dimensional massive Quantum Electrodynamics for arbitrary fermion mass. The result indicates that screening prevails for any quark masses, contrary to the classical expectations, generalizing our previous result obtained for large masses. We also test the validity of several approximation schemes using a detailed numerical analysis. The classical result is still reproduced for small separation of the quarks.Comment: latex, 10 pages, 4 figures (6 ps-files

Duality and Topological Mass Generation in Diverse Dimensions

We shall discuss issues of duality and topological mass generation in diverse dimensions. Particular emphasis will be given to the mass generation mechanism from interference between self and anti self-dual components, as disclosed by the soldering formalism. This is a gauge embedding procedure derived from an old algorithm of second-class constraint conversion used by the author to approach anomalous gauge theories. The problem of classification of the electromagnetic duality groups, both massless and massive, that is closely related will be discussed. Particular attention will be paid to a new approach to duality based on the soldering embedding to tackle the problem of mass generation by topological mechanisms in arbitrary dimensions including the couplings to dynamical matter, nonlinear cases and nonabelian symmetries.Comment: 10 pages, invited talk at "Renormalization Group and Anomalies in Gravity and Cosmology", Ouro Preto, Brazil, March 17-23, 200

Explicit Bosonization of the Massive Thirring Model in 3+1 Dimensions

We bosonize the Massive Thirring Model in 3+1D for small coupling constant and arbitrary mass. The bosonized action is explicitly obtained both in terms of a Kalb-Ramond tensor field as well as in terms of a dual vector field. An exact bosonization formula for the current is derived. The small and large mass limits of the bosonized theory are examined in both the direct and dual forms. We finally obtain the exact bosonization of the free fermion with an arbitrary mass.Comment: Latex, 7 page