Coupling of Large-Amplitude Side Chain Motions to the Excited-State H-Atom Transfer of Perylene Quinones: Application of Theory and Experiment to Calphostin C

The excited-state intramolecular H-atom transfer reactions of hypocrellins B and A are compared with those of calphostin C. On the basis of the results of transient absorption measurements and ab initio quantum mechanical calculations, it is concluded that large-amplitude conformational changes are coupled to the H-atom transfer in calphostin C, just as they are in hypocrellins A and B. The calculations on this very large molecule with a very complex ground electronic state potential energy surface were made possible by the use of highly scalable electronic structure theory codes on large parallel computers

The architectural network for protein secondary structure prediction

Over the past 25 years, the accuracy of proteins secondary structure prediction has improved substantially. Recently evolutionary information taken from the deviation of proteins in some structural family have again enhance prediction accuracy for all these residues predicted correctly is in one of the three sates helix, strands and others . The new methods developed over the past few years may be interesting in context of improvements which is achieved through combination of the existing methods. Evolutionary divergences profile posses’ adequate information to improve protein secondary structure prediction accuracy. These profiles can also able to correctly predict long stretches of identical residues in other secondary structure. This sequence structure relationship may help to help to developed tool which can efficiently predict the protein secondary structure from its amino acid sequence

A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers.publishedVersio