Barriers to use of modern contraceptives among women in an inner city area of Osogbo metropolis, Osun State, Nigeria

EO Asekun-Olarinmoye,1 WO Adebimpe,1 JO Bamidele,2 OO Odu,2 IO Asekun-Olarinmoye,3 EO Ojofeitimi41Department of Community Medicine, Faculty of Clinical Sciences, Osun State University, Osogbo, Osun State, Nigeria; 2Department of Community Medicine, Faculty of Clinical Sciences, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria; 3Department of Community Health, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria; 4Department of Community Medicine, Faculty of Clinical Sciences, Ladoke Akintola University of Technology, Osogbo, Osun State, NigeriaObjectives: To determine the knowledge and attitudes on modern contraceptive use of women living in an inner city area of Osogbo.Materials and methods: Three hundred and fifty nine women of childbearing age were studied utilizing a community-based, descriptive, cross-sectional study design. A multistage random sampling technique was used in recruiting respondents to the study. A four-part questionnaire was applied dually, by interviewers and by respondents' self administration, and the data was analyzed using the SPSS software version 17.0.Results: The mean age of respondents was 28.6 ± 6.65 years. The majority (90.3%) of respondents were aware of modern methods of family planning (FP), 76.0% claimed awareness of where to obtain FP services, and 74.9% knew of at least five methods. However, only 30.6% had ever used contraceptives, while only 13.1% were current users. The most frequently used method was the male condom. The commonly perceived barriers accounting for low use of FP methods were fear of perceived side effects (44.0%), ignorance (32.6%), misinformation (25.1%), superstition (22.0%), and culture (20.3%). Some reasons were proffered for respondents' nonuse of modern contraception. Predictors of use of modern contraceptives include the awareness of a place of FP service provision, respondents' approval of the use of contraceptives, higher education status, and being married.Conclusion: Most of the barriers reported appeared preventable and removable and may be responsible for the reported low point prevalence of use of contraceptives. It is recommended that community-based behavioral-change communication programs be instituted, aimed at improving the perceptions of women with respect to bridging knowledge gaps about contraceptive methods and to changing deep-seated negative beliefs related to contraceptive use in Nigeria.Keywords: childbearing age, family planning, fertility desires, perception, knowledge, attitude, benefit

Association between erythrocyte Na+K+-ATPase activity and some blood lipids in type 1 diabetic patients from Lagos, Nigeria

<p>Abstract</p> <p>Background</p> <p>Altered levels of erythrocyte Na⁺K⁺-ATPase, atherogenic and anti-atherogenic lipid metabolites have been implicated in diabetic complications but their pattern of interactions remains poorly understood.</p> <p>This study evaluated this relationship in Nigerian patients with Type 1 diabetes mellitus.</p> <p>Methods</p> <p>A total of 34 consented Type 1 diabetic patients and age -matched 27 non-diabetic controls were enrolled. Fasting plasma levels of total cholesterol, triglycerides and HDL-cholesterol were determined spectrophotometrically and LDL-cholesterol estimated using Friedewald formula. Total protein content and Na+K+-ATPase activity were also determined spectrophotometrically from ghost erythrocyte membrane prepared by osmotic lysis.</p> <p>Results</p> <p>Results indicate significant (P < 0.05) reduction in Na⁺K⁺-ATPase activity in the Type 1 diabetic patients (0.38 ± 0.08 vs. 0.59 ± 0.07 uM Pi/mgprotein/h) compared to the control but with greater reduction in the diabetic subgroup with poor glycemic control (n = 20) and in whom cases of hypercholesterolemia (8.8%), hypertriglyceridemia (2.9%) and elevated LDL-cholesterol (5.9% each) were found. Correlation analyses further revealed significant (P < 0.05) inverse correlations [r = -(0.708-0.797] between all the atherogenic lipid metabolites measured and Na⁺K⁺-ATPase in this subgroup contrary to group with good glycemic control or non-diabetic subjects in which significant (P < 0.05) Na⁺K⁺-ATPase and HDL-C association were found (r = 0.427 - 0.489). The Na⁺K⁺-ATPase from the diabetic patients also exhibited increased sensitivity to digoxin and alterations in kinetic constants Vmax and Km determined by glycemic status of the patients.</p> <p>Conclusion</p> <p>It can be concluded that poor glycemic control evokes greater reduction in erythrocyte Na⁺K⁺-ATPase activity and promote enzyme-blood atherogenic lipid relationships in Type 1 diabetic Nigerian patients.</p

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children &lt;18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p&lt;0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p&lt;0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p&lt;0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.

The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not yet well understood. In this study, we describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories. We show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished after the early introduction of international travel restrictions. As the pandemic progressed, ongoing transmission in many countries and increasing mobility led to the emergence and spread within the continent of many variants of concern and interest, such as B.1.351, B.1.525, A.23.1, and C.1.1. Although distorted by low sampling numbers and blind spots, the findings highlight that Africa must not be left behind in the global pandemic response, otherwise it could become a source for new variants

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Activity Schedule And Anticipation Training As Counselling Strategies In Managing Mild-depression Among Nigerian Adolescents

This study investigated the impact of Activity Schedule and AnticipationTraining as counselling strategies in managing mild depression among Nigerian adolescents. Six Senior Secondary Schools were randomly selected from three Education Districts in Lagos State. The total population of SS 2 students available for the study in the six schools was 2,982. To select the participants for the study, The Self-Rating Depression Scale (SDS) was administered to assess the cognitive, affective, psychomotor, somatic and social interpersonal dimensions of depression in the students. The SDS has a test-retest reliability coefficient of 0.93, showing good stability. After the baseline assessment, the total sample for the study comprised 96 participants. The sample accommodated all the characteristics of participants in terms of age and gender from the senior secondary schools chosen for the study. The two counselling techniques (Activity Schedule AS and Anticipation Training AT) were effective in managing mild depression (lack of concentration, feelings of guilt and worthlessness, persistent sad and empty moods). There was no significant gender difference in the post-test scores of participants across the three experimental conditions.Key words: Mild depression, Activity Schedule Therapy and Anticipatio

Occupational Hazards, Hazard Prevention and Health Problems among Workers of Local Sawmill Industries in a Fast Growing Peri-Urban Community Southwestern Nigeria

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Public perception of climate change and its impact on health and environment in rural southwestern Nigeria

Esther O Asekun-Olarinmoye,1 James O Bamidele,2 Olusola O Odu,2, Adenike I Olugbenga-Bello,3 Olugbenga L Abodurin,3 Wasiu O Adebimpe,1 Edward A Oladele,4 Adeleye A Adeomi,3 Oluwatosin A Adeoye,3 Ebenezer O Ojofeitimi31Department of Community Medicine, College of Health Sciences, Osun State University, Osogbo, Nigeria; 2Department of Community Medicine, College of Health Sciences, Ekiti State University, Ado Ekiti, Nigeria; 3Department of Community Medicine, College of Health Sciences, Faculty of Clinical Science, Ladoke Akintola University of Technology, Ogbomosho, Nigeria; 4SIDHAS Project, Family Health International, Abuja, NigeriaBackground: Climate change (CC) has received extensive media attention recently, and it is currently on the international public health agenda. A study of knowledge and attitudes to climate change, most especially from rural Nigerian communities, is important for developing adaptation strategies. This is a study of public perceptions of CC and its impact on health and environment in rural southwestern Nigeria.Methods: This was a community-based descriptive cross-sectional study of 1,019 rural respondents using a multistage sampling method. The research instrument used was a pretested, structured, interviewer-administered questionnaire. Data were analyzed using SPSS software. &chi;2, Cram&eacute;r&#39;s V, and Kendall&#39;s &tau;-c statistics were employed in addition to fitting the data to a logistic regression model to explore associations found significant on bivariate analysis.Results: Mean age of respondents was 36.9 (&plusmn;12.4) years. About 911 (89.4%) of respondents opined that there has been a change in climate in the last 10 years. Supernatural reasons were prominent among respondent-reported causes of CC. Identified risky behavior contributing to CC included smoking (10.7%), bush burning (33.4%), and tree felling (41.0%). Poor knowledge of causes but good knowledge of effects of CC were found in this study. About two-thirds of respondents had a positive attitude to causes of CC, while half had a positive attitude to the effects of CC. A significant association was found between educational status (P&lt;0.001, Kendall&#39;s &tau;-c=-0.042), occupational status (P&lt;0.01, Kendall&#39;s &tau;-c=0.088), and attitude to causes of CC. Further analysis using logistic regression showed that occupational status was significantly associated with likelihood of having a positive attitude, but educational status and marital status were not.Conclusion: Rural areas of Nigeria are vulnerable to the adverse effects of CC. Respondents&#39; poor knowledge but positive attitude to CC calls for dissemination of adequate information on CC in sustained health-promotion programs.Keywords: climate change, global warming, public perception, rural child health, environmental effec