Study of Thyroid Function Tests in Patients with Metabolic Syndrome

Background: The metabolic syndrome is a constellation of clinical and metabolic abnormalities including abdominal obesity, hypertension, dyslipidemia and impaired fasting glucose or impaired glucose tolerance. Metabolic syndrome and thyroid dysfunction are independent risk factors for cardiovascular disease. Aims and objectives: To study the prevalence, symptomatology of thyroid dysfunction and fine needle aspiration cytology (FNAC) findings of thyroid in thepatients having metabolic syndrome. Material and methods: The study was carried out in 60 cases of metabolic syndrome (according to NCEP ATP III criteria) selected from the medicine outdoor clinic (including diabetic clinics, thyroid clinics) and medicine indoor wards in Post Graduate Department of Medicine, SN Medical College and Hospital, Agra. Diagnosis of thyroid dysfunction was made by history, examination and serum FT4 and TSH. Result and observations: Out of 60 patients of metabolic syndrome, 30 patients (50%) were euthyroid, 13 patients (21.66%) had subclinical hypothyroid and 12 patients (20%) had overt hypothyroid. Five patients (8.33%) of metabolic syndrome had hyperthyroidism. Truncal obesity was most prevalent (80.0%) component of metabolic syndrome, followed by hypertriglyceridemia (70%). Diabetes mellitus was equally prevalent in both males as well as females and was present in about 40.0% patients and 53% of patients with metabolic syndrome were hypertensive. Conclusion: This study shows that 50% metabolic syndrome patients had thyroid dysfunction. About 21.66% had subclinical hypothyroidism, 20% had overt hypothyroidism and 8.33% were having hyperthyroidism. The most common symptom in metabolic syndrome patients with hypothyroidism was lethargy/ sleepiness followed by dry and coarse skin. The most common symptom in hyperthyroid patients was nervousness (100%) followed by sweating, heat intolerance and palpitation in 80% of th

Study of Thyroid Function Tests in Patients with Metabolic Syndrome

Background: The metabolic syndrome is a constellation of clinical and metabolic abnormalities including abdominal obesity, hypertension, dyslipidemia and impaired fasting glucose or impaired glucose tolerance. Metabolic syndrome and thyroid dysfunction are independent risk factors for cardiovascular disease. Aims and objectives: To study the prevalence, symptomatology of thyroid dysfunction and fine needle aspiration cytology (FNAC) findings of thyroidin the patients having metabolic syndrome. Material and methods: The study was carried out in 60 cases of metabolic syndrome (according to NCEP ATP III criteria) selected from the medicine outdoor clinic (including diabetic clinics, thyroid clinics) and medicine indoor wards in Post Graduate Department of Medicine, SN Medical College and Hospital, Agra. Diagnosis of thyroid dysfunction was made by history, examination and serum FT4 and TSH. Resultand observations: Out of 60 patients of metabolic syndrome, 30 patients (50%) were euthyroid, 13 patients (21.66%) had subclinical hypothyroid and 12 patients (20%) had overt hypothyroid. Five patients (8.33%) of metabolic syndrome had hyperthyroidism. Truncal obesity was most prevalent (80.0%) component of metabolic syndrome, followed by hypertriglyceridemia (70%). Diabetes mellitus was equally prevalent in both males as well as females and was presentin about 40.0% patients and 53% of patients with metabolic syndrome were hypertensive. Conclusion: This study shows that 50% metabolic syndrome patients had thyroid dysfunction. About 21.66% had subclinical hypothyroidism, 20% had overt hypothyroidism and 8.33% were having hyperthyroidism. The most common symptom in metabolic syndrome patients with hypothyroidism was lethargy/sleepiness followed by dry and coarse skin. The most commonsymptom in hyperthyroid patients was nervousness (100%) followed by sweating, heat intolerance and palpitation in 80% of the patients

Micro-satellite based diversity estimation of Local hill fowl (Uttara fowl): A unique poultry strain of Uttarakhand

Nainital and Pithoragarh districts of Uttarakhand in Himalayan region have 2 types of poultry populations. Uttara fowl is reared under backyard system. But no information is available in the literature of Uttara fowl. The aim of the study was to analyze the genetic diversity in Local hill fowl of Uttarakhand (Uttara Fowl) using panel of micro-satellite markers recommended by FAO. The 50 blood samples were collected from randomly selected Uttara fowl. A total of 25 micro-satellite loci were used for this study. All the analyzed 25 loci were polymorphic and a total of 158 alleles were observed in the present study of Uttara Fowl. The observed and expected heterozygosity ranged from 0.292 (LEI-155) to 0.729 (LEI-90) and from 0.414 (MCW–250) to 0.838 (MCW-228) in Uttara fowl, respectively. Wright’s fixation index (Fis) values among loci ranged from –0.085 (for LEI-90) to 0.747(MCW-84). The mean Fis for 25 microsatellite loci was estimated 0.168. Deviation from Hardy-Weinberg equilibrium was observed in Uttara fowl in the commercial cross. The overall population heterozygote deficiency was 0.168. The existence of sufficient genetic diversity within Local hill fowls, estimated through molecular markers analysis would further aid in a conservation scheme, enabling the planning of new strategies for the improvement of in situ conservation schemes

Phenolic Biotransformations during Conversion of Ferulic Acid to Vanillin by Lactic Acid Bacteria

Vanillin is widely used as food additive and as a masking agent in various pharmaceutical formulations. Ferulic acid is an important precursor of vanillin that is available in abundance in cell walls of cereals like wheat, corn, and rice. Phenolic biotransformations can occur during growth of lactic acid bacteria (LAB), and their production can be made feasible using specialized LAB strains that have been reported to produce ferulic acid esterases. The present study aimed at screening a panel of LAB isolates for their ability to release phenolics from agrowaste materials like rice bran and their biotransformation to industrially important compounds such as ferulic acid, 4-ethyl phenol, vanillic acid, vanillin, and vanillyl alcohol. Bacterial isolates were evaluated using ferulic acid esterase, ferulic acid decarboxylase, and vanillin dehydrogenase assays. This work highlights the importance of lactic acid bacteria in phenolic biotransformations for the development of food grade flavours and additives

Phenolic Biotransformations during Conversion of Ferulic Acid to Vanillin by Lactic Acid Bacteria

Vanillin is widely used as food additive and as a masking agent in various pharmaceutical formulations. Ferulic acid is an important precursor of vanillin that is available in abundance in cell walls of cereals like wheat, corn, and rice. Phenolic biotransformations can occur during growth of lactic acid bacteria (LAB), and their production can be made feasible using specialized LAB strains that have been reported to produce ferulic acid esterases. The present study aimed at screening a panel of LAB isolates for their ability to release phenolics from agrowaste materials like rice bran and their biotransformation to industrially important compounds such as ferulic acid, 4-ethyl phenol, vanillic acid, vanillin, and vanillyl alcohol. Bacterial isolates were evaluated using ferulic acid esterase, ferulic acid decarboxylase, and vanillin dehydrogenase assays. This work highlights the importance of lactic acid bacteria in phenolic biotransformations for the development of food grade flavours and additives

To compare the sensory and motor blockade produced by caudal Bupivacaine and Ropivacaine in pediatric patients

Background & Method: The aim of the study is to compare the sensory and motor blockade produced by caudal Bupivacaine and Ropivacaine in pediatric patients. Patients were randomly allocated to 1 of the 2 groups (n = 25) by using a random number table, to receive caudal block with either Inj Bupivacaine (0.25%) 1ml/kg (Group I) or Inj. Ropivacaine (0.25%) 1ml/kg (Group II). Result: The mean age distribution in Group Bupivacaine and Group Ropivacaine were almost the same without any significant difference. Heart rate and systolic arterial pressures measured at specific time intervals showed no significant difference. Conclusion: Present study was designed to compare the effect of bupivacaine versus ropivacaine used in caudal block in pediatric patients, in a prospective randomized controlled study. Mean motor score at different time intervals postoperatively was more for ropivacaine group but Heart rate and systolic arterial pressures measured at specific time intervals were similar

Study of Thyroid Function Tests in Patients with Metabolic Syndrome

The metabolic syndrome is a constellation of clinical and metabolic abnormalitiesincluding abdominal obesity, hypertension, dyslipidemia and impaired fasting glucose orimpaired glucose tolerance. Metabolic syndrome and thyroid dysfunction are independentrisk factors for cardiovascular disease. Aims and objectives: To study the prevalence,symptomatology of thyroid dysfunction and fine needle aspiration cytology (FNAC) findingsof thyroid in the patients having metabolic syndrome. Material and methods: The study wascarried out in 60 cases of metabolic syndrome (according to NCEP ATP III criteria) selectedfrom the medicine outdoor clinic (including diabetic clinics, thyroid clinics) and medicineindoor wards in Post Graduate Department of Medicine, SN Medical College and Hospital,Agra. Diagnosis of thyroid dysfunction was made by history, examination and serum FT4and TSH. Result and observations: Out of 60 patients of metabolic syndrome, 30 patients(50%) were euthyroid, 13 patients (21.66%) had subclinical hypothyroid and 12 patients (20%)had overt hypothyroid. Five patients (8.33%) of metabolic syndrome had hyperthyroidism.Truncal obesity was most prevalent (80.0%) component of metabolic syndrome, followedby hypertriglyceridemia (70%). Diabetes mellitus was equally prevalent in both males aswell as females and was present in about 40.0% patients and 53% of patients with metabolicsyndrome were hypertensive. Conclusion: This study shows that 50% metabolic syndromepatients had thyroid dysfunction. About 21.66% had subclinical hypothyroidism, 20% hadovert hypothyroidism and 8.33% were having hyperthyroidism. The most common symptomin metabolic syndrome patients with hypothyroidism was lethargy/sleepiness followed bydry and coarse skin. The most common symptom in hyperthyroid patients was nervousness(100%) followed by sweating, heat intolerance and palpitation in 80% of the patients

Prevalence of breast cancer in rural population of Jaipur: a survey-based observational study

Abstract Breast cancer, a global health concern predominantly affecting women, recorded 2.3 million new cases and 685,000 deaths in 2020. Alarmingly, projections suggest that by 2040, there could be over 3 million new cases and 1 million deaths. To assess breast cancer prevalence in 24 rural villages within a 60 km radius of NIMS Hospital, Tala Mod, Jaipur, Rajasthan, North India 303,121. A study involving 2023 participants conducted initial screenings, and positive cases underwent further tests, including ultrasound, mammography, and biopsy. SPSSv28 analysed collected data. Among 2023 subjects, 3 screened positive for breast lumps. Subsequent clinical examination and biopsy identified 1 normal case and 2 with breast cancer, resulting in a prevalence proportion of 0.0009 or 98 per 100,000. This study helps fill gap in breast cancer prevalence data for rural Rajasthan. The results highlight a concerning prevalence of breast cancer in the rural area near NIMS hospital, emphasizing the urgent need for increased awareness, early detection, and better healthcare access. Challenges like limited resources, awareness programs, and delayed diagnosis contribute to this high incidence. To address this, comprehensive approach is necessary, including improved screening programs and healthcare facilities in rural areas. Prioritizing rural healthcare and evidence-based strategies can reduce the burden of breast cancer and improve health outcomes

An In Silico Investigation to Explore Anti-Cancer Potential of Foeniculum vulgare Mill. Phytoconstituents for the Management of Human Breast Cancer

Breast cancer is one of the most prevalent cancers in the world. Traditionally, medicinal plants have been used to cure various types of diseases and disorders. Based on a literature survey, the current study was undertaken to explore the anticancer potential of Foeniculum vulgare Mill. phytoconstituents against breast cancer target protein (PDB ID: 6CHZ) by the molecular docking technique. Molecular docking was done using Autodock/vina software. Toxicity was predicted by the Protox II server and drug likeness was predicted by Molinspiration. 100 ns MD simulation of the best protein-ligand complexes were done using the Amber 18 tool. The present molecular docking investigation has revealed that among the 40 selected phytoconstituents of F. vulgare, α-pinene and D-limonene showed best binding energy (−6 and −5.9 kcal/mol respectively) with the breast cancer target. α-Pinene and D-limonene followed all the parameters of toxicity, and 100 ns MD simulations of α-pinene and D-limonene complexes with 6CHZ were found to be stable. α-Pinene and D-limonene can be used as new therapeutic agents to cure breast cancer