The usefulness of rapid diagnostic tests in the new context of low malaria transmission in zanzibar.

BACKGROUND\ud \ud We assessed if histidine-rich-protein-2 (HRP2) based rapid diagnostic test (RDT) remains an efficient tool for Plasmodium falciparum case detection among fever patients in Zanzibar and if primary health care workers continue to adhere to RDT results in the new epidemiological context of low malaria transmission. Further, we evaluated the performance of RDT within the newly adopted integrated management of childhood illness (IMCI) algorithm in Zanzibar.\ud \ud METHODS AND FINDINGS\ud \ud We enrolled 3890 patients aged ≥2 months with uncomplicated febrile illness in this health facility based observational study conducted in 12 primary health care facilities in Zanzibar, between May-July 2010. One patient had an inconclusive RDT result. Overall 121/3889 (3.1%) patients were RDT positive. The highest RDT positivity rate, 32/528 (6.1%), was found in children aged 5-14 years. RDT sensitivity and specificity against PCR was 76.5% (95% CI 69.0-83.9%) and 99.9% (95% CI 99.7-100%), and against blood smear microscopy 78.6% (95% CI 70.8-85.1%) and 99.7% (95% CI 99.6-99.9%), respectively. All RDT positive, but only 3/3768 RDT negative patients received anti-malarial treatment. Adherence to RDT results was thus 3887/3889 (99.9%). RDT performed well in the IMCI algorithm with equally high adherence among children <5 years as compared with other age groups.\ud \ud CONCLUSIONS\ud \ud The sensitivity of HRP-2 based RDT in the hands of health care workers compared with both PCR and microscopy for P. falciparum case detection was relatively low, whereas adherence to test results with anti-malarial treatment was excellent. Moreover, the results provide evidence that RDT can be reliably integrated in IMCI as a tool for improved childhood fever management. However, the relatively low RDT sensitivity highlights the need for improved quality control of RDT use in primary health care facilities, but also for more sensitive point-of-care malaria diagnostic tools in the new epidemiological context of low malaria transmission in Zanzibar.\ud \ud TRIAL REGISTRATION\ud \ud ClinicalTrials.gov NCT01002066

Nucleon and Nuclear Structure Through Dilepton Production

Transverse momentum distributions and generalized parton distributions provide a comprehensive framework for the three-dimensional imaging of the nucleon and the nucleus experimentally using deeply virtual semi-exclusive and exclusive processes. The advent of combined high luminosity facilities and large acceptance detector capabilities enables experimental investigation of the partonic structure of hadrons with time-like virtual probes, in complement to the rich on-going space-like virtual probe program. The merits and benefits of the dilepton production channel for nuclear structure studies are discussed within the context of the International Workshop on Nucleon and Nuclear Structure through Dilepton Production taking place at the European Center for Theoretical Studies in Nuclear Physics and Related Areas (ECT*) of Trento. Particularly, the double deeply virtual Compton scattering, the time-like Compton scattering, the deeply virtual meson production, and the Drell-Yan processes are reviewed and a strategy for high impact experimental measurements is proposed

The HPS electromagnetic calorimeter

The Heavy Photon Search experiment (HPS) is searching for a new gauge boson, the so-called “heavy photon.” Through its kinetic mixing with the Standard Model photon, this particle could decay into an electron-positron pair. It would then be detectable as a narrow peak in the invariant mass spectrum of such pairs, or, depending on its lifetime, by a decay downstream of the production target. The HPS experiment is installed in Hall-B of Jefferson Lab. This article presents the design and performance of one of the two detectors of the experiment, the electromagnetic calorimeter, during the runs performed in 2015–2016. The calorimeter's main purpose is to provide a fast trigger and reduce the copious background from electromagnetic processes through matching with a tracking detector. The detector is a homogeneous calorimeter, made of 442 lead-tungstate (PbWO4) scintillating crystals, each read out by an avalanche photodiode coupled to a custom trans-impedance amplifier

Test of the CLAS12 RICH large scale prototype in the direct proximity focusing configuration

A large area ring-imaging Cherenkov detector has been designed to provide clean hadron identification capability in the momentum range from 3 GeV/c up to 8 GeV/c for the CLAS12 experiments at the upgraded 12 GeV continuous electron beam accelerator facility of Jefferson Laboratory. The adopted solution foresees a novel hybrid optics design based on aerogel radiator, composite mirrors and high-packed and high-segmented photon detectors. Cherenkov light will either be imaged directly (forward tracks) or after two mirror reflections (large angle tracks). We report here the results of the tests of a large scale prototype of the RICH detector performed with the hadron beam of the CERN T9 experimental hall for the direct detection configuration. The tests demonstrated that the proposed design provides the required pion-to-kaon rejection factor of 1:500 in the whole momentum range.Comment: 15 pages, 23 figures, to appear on EPJ

Target and Beam-Target Spin Asymmetries in Exclusive Pion Electroproduction for Q\u3csup\u3e2\u3c/sup\u3e \u3e 1 GeV\u3csup\u3e2\u3c/sup\u3e . I. ep → eπ\u3csup\u3e+\u3c/sup\u3en

Beam-target double-spin asymmetries and target single-spin asymmetries were measured for the exclusive π+ electroproduction reaction γ∗p→nπ+. The results were obtained from scattering of 6-GeV longitudinally polarized electrons off longitudinally polarized protons using the CEBAF Large Acceptance Spectrometer at Jefferson Laboratory. The kinematic range covered is 1.1 \u3c W \u3c 3 GeV and 1 \u3c Q2 \u3c 6 GeV2. Results were obtained for about 6000 bins in W, Q2, cos(θ∗), and φ∗. Except at forward angles, very large target-spin asymmetries are observed over the entire W region. Reasonable agreement is found with phenomenological fits to previous data for W \u3c 1.6 GeV, but very large differences are seen at higher values of W. A generalized parton distributions (GPD)-based model is in poor agreement with the data. When combined with cross-sectional measurements, the present results provide powerful constraints on nucleon resonance amplitudes at moderate and large values of Q2, for resonances with masses as high as 2.4 GeV. © 2017 American Physical Society

Exclusive η Electroproduction at W \u3e 2 GeV with CLAS and Transversity Generalized Parton Distributions

The cross section of the exclusive η electroproduction reaction ep -\u3e e\u27p\u27 η was measured at Jefferson Laboratory with a 5.75 GeV electron beam and the CLAS detector. Differential cross sections d4σ /dtdQ2 dxBd φη and structure functions σU=σT + εσL, σTT, and σLT, as functions of t, were obtained over a wide range of Q2 and xB. The η structure functions are compared with those previously measured for π0 at the same kinematics. At low t, both π0 and eta are described reasonably well by generalized parton distributions (GPDs) in which chiral-odd transversity GPDs are dominant. The π0 and η data, when taken together, can facilitate the flavor decomposition of the transversity GPDs