Bent but not Broken : A Mixed Methods Study of Mothering During Chemotherapy for Breast Cancer

Breast cancer is the most common cancer diagnosis of women, with an estimated 232,670 new cases in 2014. With 89.2% of breast cancer patients surviving five years or longer, studies are needed to investigate the long-term impact of breast cancer on women and families (National Cancer Institute, 2014). The purpose of this study was to examine, using a mixed methods approach, the impact of chemotherapy on mothering occupations for patients diagnosed with breast cancer. Thirty-one women (mean age=39.6, SD=5.79), with breast cancer of any stage, who were currently undergoing chemotherapy and had at least one child under the age of 18 living in the home, were recruited from a comprehensive breast cancer care center. These participants completed the Fatigue Symptom Inventory Then Test, the Parent Disability Inventory, the FACT-G quality of life inventory, and a demographic questionnaire. Of these 30 participants, ten participants were selected using purposeful sampling to participate in semi-structured interviews focusing on the impact of chemotherapy on mothering occupations. Qualitative data were analyzed using a grounded theory approach (Corbin & Strauss, 2008) and quantitative data were analyzed using SPSS version 22 to determine descriptive statistics and correlations among variables. After analysis, the central category that emerged from the data was “Keeping life the same while weathering cancer treatments,” which was developed from categories of learning, adapting, accepting support, growing and normalcy. Quantitative analyses found a correlation between fatigue and parent disability (Spearman rho correlation = -0.476, p \u3c 0.05), quality of life and fatigue interference (-0.481, p \u3c 0.001) and parent disability and quality of life (0.745, p\u3c0.001). Implications for future occupational therapy practice are discussed

Chromosome numbers of plant species from the Canary Islands

Abstract.: Baltisberger M. and Widmer A. 2006. Chromosome numbers of plant species from the Canary Islands. Bot. Helv. 116: 9-30. Chromosome numbers are reported for 66 taxa (101 populations) of flowering plants representing 22 families from the Canary Islands. The chromosome numbers of Kleinia aizoides (Asteraceae, 2n=20) and Polycarpaea nivea (Caryophyllaceae, 2n=18) are given for the first time. Chromosome numbers of another 17 taxa are recorded for the first time from Canarian material. Karyotypes are presented for nine species (six endemic), and phytogeographic and for part of the species systematic aspects are discussed. For Bidens aurea, we provide evidence suggesting that this species might consist of more than one taxo

QTL Analysis of Intraspecific Differences between Two Silene vulgaris Ecotypes

• Background and Aims Serpentine soils provide a highly selective substrate for plant colonization and growth and represent an ideal system for studying the evolution of plant-ecotypes. In the present study the aim was to identify the genetic architecture of morphological traits distinguishing serpentine and non-serpentine ecotypes of Silene vulgaris. • Methods Using an F2 mapping population derived from an intraspecific cross between a serpentine and a non-serpentine ecotype of S. vulgaris, the genetic architecture of 12 morphological traits was explored using a quantitative trait locus (QTL) analysis. • Key Results The QTL analysis identified a total of 49 QTLs, of which 24 were classified as major QTLs. The mean number of QTLs per trait category was found to correspond well with numbers reported in the literature for similar crosses. Clustering of QTLs for different traits was found on several linkage groups. • Conclusions Morphological traits that differentiate the two ecotypes are strongly correlated, presumably as a consequence of the joint effects of extensive linkage of QTLs for different traits and directional selection. The signature of consistent directional selection was found for leaf and shoot trait divergence. Intraspecific ecotype differences in S. vulgaris were found to be distributed across the entire genome. The study shows that QTL analyses on non-model organisms can provide novel insights into the genetic basis of plant diversificatio

Distribution, growth performance and genetic variation of Erigeron annuus in the Swiss Alps

We investigated whether local adaptation has been important in enabling the invasive apomictic species Erigeron annuus to extend its altitudinal range in the Swiss Alps. We first conducted a field survey along several major roads crossing the Swiss Alps to study the distribution and growth performance of E. annuus along an altitudinal gradient. We then used amplified fragment length polymorphism to assess genetic variation within and among populations originating from different altitudes. To complement the molecular analyses, we compared the performance of genotypes with different distributions (i.e. local, occasional, widespread genotypes) in two common gardens at 400m and 1,000m a.s.l. Although E. annuus was seldom found above 1,000m, plant performance in field populations did not decrease with increasing altitude. However, there was a significant decline in genotypic diversity within populations, and highland (711-1,100m) populations were more differentiated (Gst=0.55) than lowland (200-530m) populations (Gst=0.33). In the common garden experiment, local genotypes (i.e. those restricted to a single population) grew less vigorously than widespread genotypes, and were less likely to reproduce. We found no evidence for on-going adaptive changes and conclude that any selection acting on particular genotypes at the altitudinal limit is weak. This leads us to propose that the patterns in the distribution of genotypic diversity in E. annuus are governed by processes of occasional sexual reproduction, dispersal and extinction that are to a large extent independent of altitud

Genetic structure and phylogeography of alpine relict populations of Ranunculus pygmaeus and Saxifraga cernua

Bauert M. R., Kälin M., Edwards P. J. and Baltisberger M. 2007. Genetic structure and phylogeography of alpine relict populations of Ranunculus pygmaeus and Saxifraga cernua. Bot. Helv. 117: 181-196. Ranunculus pygmaeus and Saxifraga cernua are arctic-alpine species with similar disjunct distributions: both occur as small, isolated relict populations in the Alps, while they are more widespread in the Arctic. To improve our understanding of their glacial and postglacial history, we investigated their genetic diversity within and among populations collected in the Alps and in the Arctic using 80 RAPD primers. We found only two genotypes of R. pygmaeus, one in the Alps and one in the Arctic. The absence of genetic diversity within each region is probably the consequence of postglacial colonization from a single source, followed by inbreeding in very small populations. In S. cernua, we found six genotypes among 11 populations in the Alps but no genetic variation within alpine populations. This limited genetic variation probably results from an extreme reduction and fragmentation of populations during successive glacial periods. In contrast, there was a high level of genetic variation both among and within all arctic populations of S. cernua. We suggest that this arose at least partly through the immigration of plants from multiple sources after the last glaciation. The higher genetic diversity of S. cernua compared to R. pygmaeus might also be related to their contrasting breeding systems: R. pygmaeus is an inbreeding diploid which propagates only by seeds, while S. cernua is a clonal polyploid which propagates mainly by vegetative means. Clonal growth, by prolonging the life span of a genotype, might contribute to the maintenance of genetic diversity under conditions which are difficult for sexual reproduction and seedling establishmen

Occupational Science: A Data-based American Perspective

The purpose of this research was to provide a data-based picture of the discipline of occupational science by identifying patterns of research in the first 5 years of presentations at the Society for the Study of Occupation: USA (SSO:USA). A grounded theory approach was used to examine 184 peerreviewed presentation abstracts, from 2002 to 2006. Among the 108 data-based presentations, adults were the most studied group, with 46% of the data-based abstracts focused on participants with a disability or clear disadvantage. Presenters’ research foci related to 4 themes: the personal experience of occupation, the context surrounding or impacting occupation, changes associated with occupation, and a descriptive perspective of occupation. Implications for occupational science are discussed

Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics

Despite huge need in the medical domain and significant development efforts, artificial cells to date have limited composition and functionality. Whereas some artificial cells have proven successful for producing therapeutics or performing in vitro specific reactions, they have not been investigated in vivo to determine whether they preserve their architecture and functionality while avoiding toxicity. Here we overcome these limitations and achieve customizable cell mimic - molecular factories (MFs) - by supplementing giant plasma membrane vesicles derived from donor cells with nanometer-sized artificial organelles (AOs). MFs inherit the donor cell's natural cytoplasm and membrane, while the AOs house reactive components and provide cell-like architecture and functionality. We demonstrate that reactions inside AOs take place in a close-to-nature environment due to the unprecedented level of complexity in the composition of the MFs. We further demonstrate that in a zebrafish vertebrate animal model these cell mimics showed no apparent toxicity and retained their integrity and function. The unique advantages of highly varied composition, multi-compartmentalized architecture, and preserved functionality in vivo open new biological avenues ranging from the study of bio-relevant processes in robust cell-like environments to the production of specific bioactive compounds

Student Voices: Engaging Diverse Learners through Shared Learning

A student panel discussion and reflection on revising an assignment from a simulation to an experiential learning activity will be presented. Student facilitators represent several majors and levels of undergraduate experiences which also allows modeling for roots of interprofessional collaboration. Students as teaching partners increases awareness of diversity and disability culture on the EKU campus