Rare Case of Hodgkin Lymphoma Transformation into Diffuse Large B-Cell Lymphoma with Atypical Spread Epidurally, Intradurally and Intramedullary : A Case Report

Publisher Copyright: © Am J Case Rep.BACKGROUND Hodgkin lymphoma (HL) transformation into diffuse large B-cell lymphoma (DLBCL) is uncommon, and scant information has been published on transformed high-grade lymphomas. Therefore, it is important to present and discuss cases of lymphoma transformation to make new information on disease progression, diagnosis, and treatment more readily available. In this paper, we present a case of HL transformation into DLBCL with atypical dissemination. CASE REPORT A 39-year-old woman presented with severe hip pain. A computed tomography (CT) scan was performed, which showed massive pathological retroperitoneal and pelvic lymphadenopathy. The lymph nodes were biopsied and revealed HL. The patient then underwent 7 cycles of ABVD therapy; however, clinical concern was raised for persistent disease due to the poor response to therapy. A vertebral body biopsy was performed to clarify the diagnosis, and histological analysis revealed DLBCL. Therefore, specific chemotherapy with the R-CHOP scheme was begun; the patient received 8 cycles of rituximab and residual lymphoma tissue irradiation. Two months later, magnetic resonance imaging later demonstrated radiological disease progression with multiple widespread metastases in the spinal vertebrae as well as prevertebral, epidural, intradural, and intramedullary metastatic spread. The patient underwent intrathecal chemotherapy and radiation therapy, after which, full metabolic remission was observed on PET/CT. CONCLUSIONS Vigilance should be maintained for patients with poor response to HL treatment owing to the possible transformation into DLBCL. However, even in such cases, full metabolic remission can be achieved with appropriate treatment.publishersversionPeer reviewe

Promotion of adaption of pre-school children aged 2-3

Darba autore: Ginta Balode Darba nosaukums: 2–3 gadus vecu bērnu adaptācijas veicināšana pirmsskolas izglītības iestādē Darba veids: kvalifikācijas darbs Studiju programma: pirmsskolas izglītības skolotājs Darba zinātniskais vadītājs: Mg. Paed., Mg. Psych. Ilze Kricka Darba apjoms: 47 lpp., anotācija, ievads, 2 nodaļas ar apakšnodaļām, teorētiskā daļa, empīriskā daļa, secinājumi, priekšlikumi, tabulu skaits – 8, literatūras avotu skaits – 26, pielikumi – 2 Pētījuma mērķis: teorētiski analizēt, kā arī praktiski noskaidrot, kādas darba metodes sekmē 2 – 3 gadus vecu bērnu adaptācijas veicināšanu pirmsskolas izglītības iestādē. Galvenie darba uzdevumi: •Analizēt teorētisko literatūru par adaptācijas veicināšanu pirmsskolas izglītības iestādē. •Veikt praktisku pētījumu par veiksmīgas adaptācijas veicināšanu pirmsskolas izglītības iestādē ‘’X’’. Darba gaita: Kvalifikācijas darbā analizēti dažādu psihologu, pedagogu un pediatru ieteikumi adaptācijas veiksmīgai norisei. Pētījumā novēroti grupas bērni, kā arī veikta vecāku anketēšana un pārrunas. Darba izstrādes laikā hipotēze – 2 – 3 gadus vecu bērnu adaptācija būs veiksmīga, ja pirmsskolas izglītības pedagogs iepazīs katra bērna vajadzības, kā arī sadarbosies ar bērnu vecākiem, apstiprinājās. Atslēgas vārdi: adaptācija, adaptācijas veicināšana, pedagogu un vecāku sadarbība.Author: Ginta Balode Title: Promotion of adaptation of preschool children of 2-3 years Type of work: qualification work Study program: Preschool teacher Scientific supervisor of the work: Mg. Paed., Mg. Psychic. Ilze Kricka Workload: 47 pages, Annotation, introduction, 2 chapters with subdivisions, theoretical part, empirical part, conclusions, suggestions, number of tables - 8, number of literature sources – 26, addition – 2. Aim of the research: to theoretically analyze as well as to find out in practice, using working methods contributes to the promotion of adaptation of preschool children at the age of 2 - 3 years. Main tasks: • Analyze theoretical literature on the promotion of adaptation in pre-school education. • Conduct a practical study on the promotion of successful adaptation in pre-school education institution '' X ''. Workflow: The qualification paper analyzes the recommendations of various psychologists, educators and pediatricians for successful adaptation. The study observed children in the group, as well as questionnaires and interviews with parents. During the elaboration of the thesis, the hypothesis - adaptation of 2 - 3 year old children will be successful if the preschool teacher learns the needs of each child and cooperates with the parents of the children. Keywords: adaptation, promotion of adaptation, cooperation between educators and parents.

User Behavior in Multi-Screen Elearning

This article reports on the progress we have achieved as we continue to pilot new approaches using an eEcosystem that is based on a multi-screen concept to support e-learning. Here we recap our recent progress with the project JAUZI/eBig3 that is a multi-screen e-learning development. The approach effectively integrates the popular technologies of television, Internet, and mobile phones. It is a new way of using technology to support and encourage engagement in the lifelong learning process. Here we present the results of ten course pilots offered in 2013 with the eBig3-learning format as well as the teacher training courses offered by the MII project (Modern Education of Interests) in 2014. The target group of eBig3 courses was general public, but for the MII courses it was teachers. We compared the user behavior data from the various presented courses with the number of learning objects to the number of users. The normalised curves of the user behavior data graph are a valuable source for data analysis to teachers and course developers because they profile effectiveness of course content and delivery approach in respect to target group expections. Our observations about the variance in user behavior distribution between mandatory and optional courses can be used as a potential quality indicator for the success of eLearning courses

"eBig3": A New Triple Screen Approach for the Next Generation of Lifelong Learning

In this report we want to map out our progress on design science research project ETM that creates a new approach to lifelong learning by the smart integration of the popular technologies Internet, mobile phones, and television [1,2,3]. By studying the results of the target group behaviour as they simultaneously use of these technologies, we designed the learning approach eBig3 that is based on user usage patterns. The evaluation of the initial delivery of the courses confirms the interest of the target group and their commitment to continue-on to pass the courses