608 research outputs found
Phase 2, Open-Label, International, Non-Comparative Study of MEDI4736 in Patients with Locally Advanced or Metastatic, Pd-L1 +, Stage 3B–4 Nsclc Who Have Received ≥2 Prior Systemic Treatment Regimens (ATLANTIC)
n/
What determines auditory similarity? The effect of stimulus group and methodology.
Two experiments on the internal representation of auditory stimuli compared the pairwise and grouping methodologies as means of deriving similarity judgements. A total of 45 undergraduate students participated in each experiment, judging the similarity of short auditory stimuli, using one of the methodologies. The experiments support and extend Bonebright's (1996) findings, using a further 60 stimuli. Results from both methodologies highlight the importance of category information and acoustic features, such as root mean square (RMS) power and pitch, in similarity judgements. Results showed that the grouping task is a viable alternative to the pairwise task with N > 20 sounds whilst highlighting subtle differences, such as cluster tightness, between the different task results. The grouping task is more likely to yield category information as underlying similarity judgements
Resource Utilization Due to Breakthrough Pain in Patients With Chronic Painful Conditions
Objectives Primary: To capture healthcare resource consumption and work loss in a population of patients with chronic pain who have pain flares from one or more non-cancer conditions.
Secondary: To explore the relationship between anxiety, depression, and pain in this population
Perception of Breakthrough Pain in Patients with Chronic Painful Conditions
Objective: To understand how patients with chronic non-cancer pain define and describe pain flares
Aged garlic extract therapy for sickle cell anemia patients
BACKGROUND: Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). METHODS: Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. RESULTS: The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). CONCLUSIONS: These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia
Peri-ampullary mixed acinar-endocrine carcinoma
Mixed acinar-endocrine carcinomas (MAEC) are rare tumors of the pancreas. We present the case of a patient with periampullary tumor that presented with painless jaundice and after investigation was found to have MAEC. He underwent pancreaticoduo-dunectomy with tumor free margins and negative lymph nodes. The patient presented with local recurrence and liver metastasis after 1 year and is on chemotherapy with stable lesions 30 months after the diagnosis
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis
Designing informative warning signals: Effects of indicator type, modality, and task demand on recognition speed and accuracy
An experiment investigated the assumption that natural indicators which exploit
existing learned associations between a signal and an event make more effective
warnings than previously unlearned symbolic indicators. Signal modality (visual,
auditory) and task demand (low, high) were also manipulated. Warning
effectiveness was indexed by accuracy and reaction time (RT) recorded during
training and dual task test phases. Thirty-six participants were trained to
recognize 4 natural and 4 symbolic indicators, either visual or auditory, paired
with critical incidents from an aviation context. As hypothesized, accuracy was
greater and RT was faster in response to natural indicators during the training
phase. This pattern of responding was upheld in test phase conditions with
respect to accuracy but observed in RT only in test phase conditions involving
high demand and the auditory modality. Using the experiment as a specific
example, we argue for the importance of considering the cognitive contribution
of the user (viz., prior learned associations) in the warning design process.
Drawing on semiotics and cognitive psychology, we highlight the indexical nature
of so-called auditory icons or natural
indicators and argue that the cogniser is an indispensable element
in the tripartite nature of signification
- …