An automated data management/analysis system for space shuttle orbiter tiles

An engineering data management system was combined with a nonlinear stress analysis program to provide a capability for analyzing a large number of tiles on the space shuttle orbiter. Tile geometry data and all data necessary of define the tile loads environment accessed automatically as needed for the analysis of a particular tile or a set of tiles. User documentation provided includes: (1) description of computer programs and data files contained in the system; (2) definitions of all engineering data stored in the data base; (3) characteristics of the tile anaytical model; (4) instructions for preparation of user input; and (5) a sample problem to illustrate use of the system. Description of data, computer programs, and analytical models of the tile are sufficiently detailed to guide extension of the system to include additional zones of tiles and/or additional types of analyse

Treatment of dental complications in sickle cell disease.

BACKGROUND: Sickle cell disease is the most common single gene disorder and the commonest haemoglobinopathy found with high prevalence in many populations across the world. Management of dental complications in people with sickle cell disease requires special consideration for three main reasons. Firstly, dental and oral tissues are affected by the blood disorder resulting in several oro-facial abnormalities. Secondly, living with a haemoglobinopathy and coping with its associated serious consequences may result in individuals neglecting their oral health care. Finally, the treatment of these oral complications must be adapted to the systemic condition and special needs of these individuals, in order not to exacerbate or deteriorate their general health.Guidelines for the treatment of dental complications in this population who require special care are unclear and even unavailable in many aspects. Hence this review was undertaken to provide a basis for clinical care by investigating and analysing the existing evidence in the literature for the treatment of dental complications in people with sickle cell disease. OBJECTIVES: To assess methods of treating dental complications in people with sickle cell disease. SEARCH METHODS: We searched the Cochrane Haemoglobinopathies Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books.Date of last search: 11 April 2016.Additionally, we searched nine online databases (PubMed, Google Scholar, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Literature in the Health Sciences in Latin America and the Caribbean database, African Index Medicus, Index Medicus for South East Asia Region, Index Medicus for the Eastern Mediterranean Region, Indexing of Indian Medical Journals). We also searched the reference lists of relevant articles and reviews and contacted haematologists, experts in fields of dentistry, organizations, pharmaceutical companies and researchers working in this field.Date of last search: 03 March 2016. SELECTION CRITERIA: We searched for published or unpublished randomised controlled studies of treatments for dental complications in people with sickle cell disease. DATA COLLECTION AND ANALYSIS: Two review authors intended to independently extract data and assess the risk of bias of the included studies using standard Cochrane methodologies; however, no studies were identified for inclusion in the review. MAIN RESULTS: No randomised controlled studies were identified. AUTHORS\u27 CONCLUSIONS: This Cochrane review did not identify any randomised controlled studies assessing interventions for the treatment of dental complications in people with sickle cell disease. There is an important need for randomised controlled studies in this area, so as to identify the most effective and safe method for treating dental complications in people with sickle cell disease

Estimating Small Area Income Deprivation: An Iterative Proportional Fitting Approach

Small area estimation and in particular the estimation of small area income deprivation has potential value in the development of new or alternative components of multiple deprivation indices. These new approaches enable the development of income distribution threshold based as opposed to benefit count based measures of income deprivation and so enable the alignment of regional and national measures such as the Households Below Average Income with small area measures. This paper briefly reviews a number of approaches to small area estimation before describing in some detail an iterative proportional fitting based spatial microsimulation approach. This approach is then applied to the estimation of small area HBAI rates at the small area level in Wales in 2003-5. The paper discusses the results of this approach, contrasts them with contemporary ‘official’ income deprivation measures for the same areas and describes a range of ways to assess the robustness of the results

The design of mixed-use virtual auditory displays: Recent findings with a dual-task paradigm

Presented at the 10th International Conference on Auditory Display (ICAD2004)In the third of an ongoing series of exploratory sound information display studies, we augmented a dual task with a mixed-use auditory display designed to provide relevant alert information for each task. The tasks entail a continuous tracking activity and a series of intermittent classification decisions that, in the present study, were presented on separate monitors that were roughly 90\,^{\circ} apart. Using a 2-by-3 design that manipulated both the use of sound in each task and where sounds for the decision task were positioned, the following principal questions were addressed: Can tracking performance be improved with a varying auditory alert tied to error? To what degree do listeners use virtual auditory deixis as a cue for improving decision reaction times? Can a previous finding involving participants' use of sound offsets (cessations) be repeated? And, last, are there performance consequences when auditory displays for separate tasks are combined? Respectively, we found that: Tracking performance as measured by RMS error was not improved and was apparently negatively affected by the use of our auditory design. Listener's use of even limited virtual auditory deixis is robust, but it is probably also sensitive to the degree it is coincident with the location of corresponding visual stimuli in the task environment. On the basis of manually collected head movement data, listeners do make opportunistic use of sound offsets. And, finally, a significant interaction, as measured by average participant reaction time, was observed between the auditory display used for one task and the manipulation of the degree of auditory deixis encoded in the auditory display used for the other task in our paradigm

Tame and relatively elliptic CP1\mathbb{CP}^1-structures on the thrice-punctured sphere

Suppose a relatively elliptic representation $\rho$ of the fundamental group of the thrice-punctured sphere $S$ is given. We prove that all projective structures on $S$ with holonomy $\rho$ and satisfying a tameness condition at the punctures can be obtained by grafting certain circular triangles. The specific collection of triangles is determined by a natural framing of $\rho$. In the process, we show that (on a general surface $\Sigma$ of negative Euler characteristics) structures satisfying these conditions can be characterized in terms of their M\"obius completion, and in terms of certain meromorphic quadratic differentials.Comment: 58 pages, 19 figures, comments welcom

A 2-year intercomparison of the WAM-Cycle4 and the WAVEWATCH-III wave models implemented within the Mediterranean Sea

In this work we present the implementation of a wave forecast/hindcast system for the Mediterranean Sea at a 1/10º horizontal resolution and we show a first assessment of its performance by inter-comparing model results to observational data time series at selected points for the period 2000-2001. The system which is part of the POSEIDON-II operational system includes the WAM – Cycle4 and the WAVEWATCH-III wave forecast models (implemented within the same region) one way coupled with the non-hydrostatic version of the ETA atmospheric model which provides at 3-hour intervals the necessary wind velocity fields to the wave models. The same system but based on the WAM-Cycle4 wave model, has been used in the past for the production of the Aegean Sea wind and wave Atlas. Overall, the inter-comparison shows that both wave models are rather skilful in predicting the integral wave parameters with significant wave height skill scores in the range 0.85-0.90 and mean period scores in the range 0.77-0.83. It is also evident that WAM model has a tendency to overestimate mean wave periods while the opposite is true for WAVEWATCH-III model. Differences between the two models simulated spectra exist along the main passage of cyclonic systems over the Mediterranean Sea while in the wind seas dominated areas of the basin (the Aegean Sea for example) the two models show almost the same behavior

What determines auditory similarity? The effect of stimulus group and methodology.

Two experiments on the internal representation of auditory stimuli compared the pairwise and grouping methodologies as means of deriving similarity judgements. A total of 45 undergraduate students participated in each experiment, judging the similarity of short auditory stimuli, using one of the methodologies. The experiments support and extend Bonebright's (1996) findings, using a further 60 stimuli. Results from both methodologies highlight the importance of category information and acoustic features, such as root mean square (RMS) power and pitch, in similarity judgements. Results showed that the grouping task is a viable alternative to the pairwise task with N > 20 sounds whilst highlighting subtle differences, such as cluster tightness, between the different task results. The grouping task is more likely to yield category information as underlying similarity judgements

Dynamic downscaling of the ERA-40 data using a mesoscale meteorological model

A sophisticated downscaling procedure that was applied to reproduce high resolution historical records of the atmospheric conditions across the Mediterranean region is presented in this paper. This was accomplished by the dynamical downscaling of the European Center for Medium-Range Forecasts ERA-40 reanalyses with the aid of the atmospheric model of the POSEIDON weather forecasting system. The full three dimensional atmospheric fields with 6 hours of temporal resolution and the surface meteorological parameters at hourly intervals were produced for a 10-year period (1995-2004). The meteorological variables are readily available at 10 km resolution and may constitute the atmospheric forcing to drive wave, ocean hydrodynamic and hydrological models, as well as the baseline data for environmental impact assessment studies. A brief overview of the procedure and a quantitative estimation of the benefit of the new dynamical downscaling dataset are presented

Resource Utilization Due to Breakthrough Pain in Patients With Chronic Painful Conditions

Objectives Primary: To capture healthcare resource consumption and work loss in a population of patients with chronic pain who have pain flares from one or more non-cancer conditions. Secondary: To explore the relationship between anxiety, depression, and pain in this population