Effect of Solvent Choice on the Self-Assembly Properties of a Diphenylalanine Amphiphile Stabilized by an Ion Pair

A diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules was studied by considering a peptide solution in an organic solvent and adding pure water, a KCl solution, or another organic solvent as co-solvent. The choice of the organic solvent and co-solvent and the solvent/co-solvent ratio allowed the mixture to be tuned by modulating the polarity, the ionic strength, and the peptide concentration. Differences in the properties of the media used to dissolve the peptides resulted in the formation of different self-assembled microstructures (e.g. fibers, branched-like structures, plates, and spherulites). Furthermore, crystals of TFAFF-OBzl were obtained from the aqueous peptide solutions for X-ray diffraction analysis. The results revealed a hydrophilic core constituted by carboxylate (from TFA), ester, and amide groups, and the core was found to be surrounded by a hydrophobic crown with ten aromatic rings. This segregated organization explains the assemblies observed in the different solvent mixtures as a function of the environmental polarity, ionic strength, and peptide concentration

Polarized blazar X-rays imply particle acceleration in shocks

Full list of authors: Liodakis, Ioannis; Marscher, Alan P.; Agudo, Ivan; Berdyugin, Andrei V.; Bernardos, Maria I.; Bonnoli, Giacomo; Borman, George A.; Casadio, Carolina; Casanova, Victor; Cavazzuti, Elisabetta; Cavero, Nicole Rodriguez; Di Gesu, Laura; Di Lalla, Niccolo; Donnarumma, Immacolata; Ehlert, Steven R.; Errando, Manel; Escudero, Juan; Garcia-Comas, Maya; Agis-Gonzalez, Beatriz; Husillos, Cesar; Jormanainen, Jenni; Jorstad, Svetlana G.; Kagitani, Masato; Kopatskaya, Evgenia N.; Kravtsov, Vadim; Krawczynski, Henric; Lindfors, Elina; Larionova, Elena G.; Madejski, Grzegorz M.; Marin, Frederic; Marchini, Alessandro; Marshall, Herman L.; Morozova, Daria A.; Massaro, Francesco; Masiero, Joseph R.; Mawet, Dimitri; Middei, Riccardo; Millar-Blanchaer, Maxwell A.; Myserlis, Ioannis; Negro, Michela; Nilsson, Kari; O'Dell, Stephen L.; Omodei, Nicola; Pacciani, Luigi; Paggi, Alessandro; Panopoulou, Georgia V.; Peirson, Abel L.; Perri, Matteo; Petrucci, Pierre-Olivier; Poutanen, Juri; Puccetti, Simonetta; Romani, Roger W.; Sakanoi, Takeshi; Savchenko, Sergey S.; Sota, Alfredo; Tavecchio, Fabrizio; Tinyanont, Samaporn; Vasilyev, Andrey A.; Weaver, Zachary R.; Zhovtan, Alexey V.; Antonelli, Lucio A.; Bachetti, Matteo; Baldini, Luca; Baumgartner, Wayne H.; Bellazzini, Ronaldo; Bianchi, Stefano; Bongiorno, Stephen D.; Bonino, Raffaella; Brez, Alessandro; Bucciantini, Niccolo; Capitanio, Fiamma; Castellano, Simone; Ciprini, Stefano; Costa, Enrico; De Rosa, Alessandra; Del Monte, Ettore; Di Marco, Alessandro; Doroshenko, Victor; Dovciak, Michal; Enoto, Teruaki; Evangelista, Yuri; Fabiani, Sergio; Ferrazzoli, Riccardo; Garcia, Javier A.; Gunji, Shuichi; Hayashida, Kiyoshi; Heyl, Jeremy; Iwakiri, Wataru; Karas, Vladimir; Kitaguchi, Takao; Kolodziejczak, Jeffery J.; La Monaca, Fabio; Latronico, Luca; Maldera, Simone; Manfreda, Alberto; Marinucci, Andrea; Matt, Giorgio; Mitsuishi, Ikuyuki; Mizuno, Tsunefumi; Muleri, Fabio; Ng, Stephen C. -Y.; Oppedisano, Chiara; Papitto, Alessandro; Pavlov, George G.; Pesce-Rollins, Melissa; Pilia, Maura; Possenti, Andrea; Ramsey, Brian D.; Rankin, John; Ratheesh, Ajay; Sgro, Carmelo; Slane, Patrick; Soffitta, Paolo; Spandre, Gloria; Tamagawa, Toru; Taverna, Roberto; Tawara, Yuzuru; Tennant, Allyn F.; Thomas, Nicolas E.; Tombesi, Francesco; Trois, Alessio; Tsygankov, Sergey; Turolla, Roberto; Vink, Jacco; Weisskopf, Martin C.; Wu, Kinwah; Xie, Fei; Zane, Silvia.--This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Most of the light from blazars, active galactic nuclei with jets of magnetized plasma that point nearly along the line of sight, is produced by high-energy particles, up to around 1 TeV. Although the jets are known to be ultimately powered by a supermassive black hole, how the particles are accelerated to such high energies has been an unanswered question. The process must be related to the magnetic field, which can be probed by observations of the polarization of light from the jets. Measurements of the radio to optical polarization—the only range available until now—probe extended regions of the jet containing particles that left the acceleration site days to years earlier1,2,3, and hence do not directly explore the acceleration mechanism, as could X-ray measurements. Here we report the detection of X-ray polarization from the blazar Markarian 501 (Mrk 501). We measure an X-ray linear polarization degree ΠX of around 10%, which is a factor of around 2 higher than the value at optical wavelengths, with a polarization angle parallel to the radio jet. This points to a shock front as the source of particle acceleration and also implies that the plasma becomes increasingly turbulent with distance from the shock. © The Author(s) 2022.I.L. was supported by the JSPS postdoctoral short-term fellowship programme. The Imaging X-ray Polarimetry Explorer (IXPE) is a joint US and Italian mission. The US contribution is supported by the National Aeronautics and Space Administration (NASA) and led and managed by its Marshall Space Flight Center (MSFC), with industry partner Ball Aerospace (contract NNM15AA18C). The Italian contribution is supported by the Italian Space Agency (Agenzia Spaziale Italiana, ASI) through contract ASI-OHBI-2017-12-I.0, agreements ASI-INAF-2017-12-H0 and ASI-INFN-2017.13-H0, and its Space Science Data Center (SSDC) with agreements ASI-INAF-2022-14-HH.0 and ASI-INFN 2021-43-HH.0, and by the Istituto Nazionale di Astrofisica (INAF) and the Istituto Nazionale di Fisica Nucleare (INFN) in Italy. This research used data products provided by the IXPE Team (MSFC, SSDC, INAF and INFN) and distributed with additional software tools by the High-Energy Astrophysics Science Archive Research Center (HEASARC), at NASA Goddard Space Flight Center (GSFC). Data from the Steward Observatory spectropolarimetric monitoring project were used. This programme is supported by Fermi Guest Investigator grants NNX08AW56G, NNX09AU10G, NNX12AO93G and NNX15AU81G. This research has made use of data from the RoboPol programme, a collaboration between Caltech, the University of Crete, the Institute of Astrophysics-Foundation for Research and Technology (IA-FORTH), the Inter-University Centre for Astronomy and Astrophysics (IUCAA), the Max Planck Institute for Radioastronomy (MPIfR) and the Nicolaus Copernicus University, which was conducted at Skinakas Observatory in Crete, Greece. The Instituto Astrofísica Andalucía (IAA)-Consejo Superior de Investigaciones Científicas (CSIC) co-authors acknowledge financial support from the Spanish Ministerio de Ciencia e Innovacion (MCINN) through the ‘Center of Excellence Severo Ochoa‘ award for the Instituto de Astrofisica de Andalucia-CSIC (SEV-2017-0709). Acquisition and reduction of the POLAMI and Monitoring AGN with Polarimetry at the Calar Alto Telescopes (MAPCAT) data were supported in part by Ministerio de Ciencia e Innovación (MICINN) through grants AYA2016-80889-P and PID2019-107847RB-C44. The POLAMI observations were carried out at the IRAM 30 m Telescope. IRAM is supported by the National Institute of Sciences of the Universe (INSU)/Scientific Research National Center (CNRS) (France), Max-Planck-Gesellschaft (MPG) (Germany) and Instituto Geográfico Nacional (IGN) (Spain). The research at Boston University was supported in part by National Science Foundation grant AST-2108622, NASA Fermi Guest Investigator grant 80NSSC21K1917 and NASA Swift Guest Investigator grant 80NSSC22K0537. This study uses observations conducted with the 1.8 m Perkins Telescope Observatory in Arizona (USA), which is owned and operated by Boston University. Based on observations obtained at the Hale Telescope, Palomar Observatory as part of a continuing collaboration between the California Institute of Technology, NASA/Jet Propulsion Laboratory (JPL), Yale University and the National Astronomical Observatories of China. This research made use of Photutils, an Astropy package for detection and photometry of astronomical sources60. G.V.P. acknowledges support by NASA through the NASA Hubble Fellowship grant no. HST-HF2-51444.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. Based on observations made with the Nordic Optical Telescope, owned in collaboration by the University of Turku and Aarhus University, and operated jointly by Aarhus University, the University of Turku and the University of Oslo, representing Denmark, Finland and Norway, the University of Iceland and Stockholm University at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. The data presented here were obtained (in part) with ALFOSC, which is provided by the Instituto de Astrofisica de Andalucia (IAA) under a joint agreement with the University of Copenhagen and the Nordic Optical Telescope. V.K. thanks the Vilho, Yrjö and Kalle Väisälä Foundation. J.J. was supported by Academy of Finland project 320085. E.L. was supported by Academy of Finland projects 317636 and 320045. Part of the French contribution was supported by the CNRS and the French spatial agency (CNES). Based on observations collected at the Observatorio de Sierra Nevada, owned and operated by the Instituto de Astrofisica de Andalucia (IAA-CSIC). Based on observations collected at the Centro Astronomico Hispano-Aleman (CAHA), proposal 22A-2.2-015, operated jointly by Junta de Andalucia and Consejo Superior de Investigaciones Cientificas (IAA-CSIC).Peer reviewe

X-Ray Polarization Observations of BL Lacertae

Full list of authors: Middei, Riccardo; Liodakis, Ioannis; Perri, Matteo; Puccetti, Simonetta; Cavazzuti, Elisabetta; Di Gesu, Laura; Ehlert, Steven R.; Madejski, Grzegorz; Marscher, Alan P.; Marshall, Herman L.; Muleri, Fabio; Negro, Michela; Jorstad, Svetlana G.; Agis-Gonzalez, Beatriz; Agudo, Ivan; Bonnoli, Giacomo; Bernardos, Maria, I; Casanova, Victor; Garcia-Comas, Maya; Husillos, Cesar; Marchini, Alessandro; Sota, Alfredo; Kouch, Pouya M.; Lindfors, Elina; Borman, George A.; Kopatskaya, Evgenia N.; Larionova, Elena G.; Morozova, Daria A.; Savchenko, Sergey S.; Vasilyev, Andrey A.; Zhovtan, Alexey, V; Casadio, Carolina; Escudero, Juan; Myserlis, Ioannis; Hales, Antonio; Kameno, Seiji; Kneissl, Ruediger; Messias, Hugo; Nagai, Hiroshi; Blinov, Dmitry; Bourbah, Ioakeim G.; Kiehlmann, Sebastian; Kontopodis, Evangelos; Mandarakas, Nikos; Romanopoulos, Stylianos; Skalidis, Raphael; Vervelaki, Anna; Masiero, Joseph R.; Mawet, Dimitri; Millar-Blanchaer, Maxwell A.; Panopoulou, Georgia, V; Tinyanont, Samaporn; Berdyugin, Andrei, V; Kagitani, Masato; Kravtsov, Vadim; Sakanoi, Takeshi; Imazawa, Ryo; Sasada, Mahito; Fukazawa, Yasushi; Kawabata, Koji S.; Uemura, Makoto; Mizuno, Tsunefumi; Nakaoka, Tatsuya; Akitaya, Hiroshi; Gurwell, Mark; Rao, Ramprasad; Di Lalla, Niccolo; Cibrario, Nicolo; Donnarumma, Immacolata; Kim, Dawoon E.; Omodei, Nicola; Pacciani, Luigi; Poutanen, Juri; Tavecchio, Fabrizio; Antonelli, Lucio A.; Bachetti, Matteo; Baldini, Luca; Baumgartner, Wayne H.; Bellazzini, Ronaldo; Bianchi, Stefano; Bongiorno, Stephen D.; Bonino, Raffaella; Brez, Alessandro; Bucciantini, Niccolo; Capitanio, Fiamma; Castellano, Simone; Ciprini, Stefano; Costa, Enrico; De Rosa, Alessandra; Del Monte, Ettore; Di Marco, Alessandro; Doroshenko, Victor; Dovciak, Michal; Enoto, Teruaki; Evangelista, Yuri; Fabiani, Sergio; Ferrazzoli, Riccardo; Garcia, Javier A.; Gunji, Shuichi; Hayashida, Kiyoshi; Heyl, Jeremy; Iwakiri, Wataru; Karas, Vladimir; Kitaguchi, Takao; Kolodziejczak, Jeffery J.; Krawczynski, Henric; La Monaca, Fabio; Latronico, Luca; Maldera, Simone; Manfreda, Alberto; Marin, Frederic; Marinucci, Andrea; Massaro, Francesco; Matt, Giorgio; Mitsuishi, Ikuyuki; Ng, C-Y; O'Dell, Stephen L.; Oppedisano, Chiara; Papitto, Alessandro; Pavlov, George G.; Peirson, Abel L.; Pesce-Rollins, Melissa; Petrucci, Pierre-Olivier; Pilia, Maura; Possenti, Andrea; Ramsey, Brian D.; Rankin, John; Ratheesh, Ajay; Romani, Roger W.; Sgro, Carmelo; Slane, Patrick; Soffitta, Paolo; Spandre, Gloria; Tamagawa, Toru; Taverna, Roberto; Tawara, Yuzuru; Tennant, Allyn F.; Thomas, Nicholas E.; Tombesi, Francesco; Trois, Alessio; Tsygankov, Sergey; Turolla, Roberto; Vink, Jacco; Weisskopf, Martin C.; Wu, Kinwah; Xie, Fei; Zane, Silvia.--This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Blazars are a class of jet-dominated active galactic nuclei with a typical double-humped spectral energy distribution. It is of common consensus that the synchrotron emission is responsible for the low frequency peak, while the origin of the high frequency hump is still debated. The analysis of X-rays and their polarization can provide a valuable tool to understand the physical mechanisms responsible for the origin of high-energy emission of blazars. We report the first observations of BL Lacertae (BL Lac) performed with the Imaging X-ray Polarimetry Explorer, from which an upper limit to the polarization degree ΠX < 12.6% was found in the 2–8 keV band. We contemporaneously measured the polarization in radio, infrared, and optical wavelengths. Our multiwavelength polarization analysis disfavors a significant contribution of proton-synchrotron radiation to the X-ray emission at these epochs. Instead, it supports a leptonic origin for the X-ray emission in BL Lac. © 2022. The Author(s). Published by the American Astronomical Society.The Imaging X-ray Polarimetry Explorer (IXPE) is a joint US and Italian mission. The US contribution is supported by the National Aeronautics and Space Administration (NASA) and led and managed by its Marshall Space Flight Center (MSFC), with industry partner Ball Aerospace (contract NNM15AA18C). The Italian contribution is supported by the Italian Space Agency (Agenzia Spaziale Italiana, ASI) through contract ASI-OHBI-2017-12-I.0, agreements ASI-INAF-2017-12-H0 and ASI-INFN-2017.13-H0, and its Space Science Data Center (SSDC), and by the Istituto Nazionale di Astrofisica (INAF) and the Istituto Nazionale di Fisica Nucleare (INFN) in Italy. This research used data products provided by the IXPE Team (MSFC, SSDC, INAF, and INFN) and distributed with additional software tools by the High-Energy Astrophysics Science Archive Research Center (HEASARC), at NASA Goddard Space Flight Center (GSFC). We acknowledge financial support from ASI-INAF agreement n. 2022-14-HH.0. The research at Boston University was supported in part by National Science Foundation grant AST-2108622 and NASA Swift Guest Investigator grant 80NSSC22K0537. This research has made use of data from the RoboPol program, a collaboration between Caltech, the University of Crete, IA-FORTH, IUCAA, the MPIfR, and the Nicolaus Copernicus University, which was conducted at Skinakas Observatory in Crete, Greece. The IAA-CSIC coauthors acknowledge financial support from the Spanish "Ministerio de Ciencia e Innovacion" (MCINN) through the "Center of Excellence Severo Ochoa" award for the Instituto de Astrofísica de Andalucía-CSIC (SEV-2017-0709). Acquisition and reduction of the POLAMI, TOP-MAPCAR, and OSN data was supported in part by MICINN through grants AYA2016-80889-P and PID2019-107847RB-C44. The POLAMI observations were carried out at the IRAM 30 m Telescope. IRAM is supported by INSU/CNRS (France), MPG (Germany), and IGN (Spain). This Letter makes use of the following ALMA director's discretionary time data under proposal ESO#2021.A.00016.T. ALMA is a partnership of ESO (representing its member states), NSF (USA), and NINS (Japan), together with NRC (Canada), MOST, and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. Some of the data reported here are based on observations obtained at the Hale Telescope, Palomar Observatory as part of a continuing collaboration between the California Institute of Technology, NASA/JPL, Yale University, and the National Astronomical Observatories of China. This research made use of Photutils, an Astropy package for detection and photometry of astronomical sources (Bradley et al. 2019). G.V.P. acknowledges support by NASA through the NASA Hubble Fellowship grant #HST-HF2-51444.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. The data in this study include observations made with the Nordic Optical Telescope, owned in collaboration by the University of Turku and Aarhus University, and operated jointly by Aarhus University, the University of Turku, and the University of Oslo, representing Denmark, Finland, and Norway, the University of Iceland and Stockholm University at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. The data presented here were obtained in part with ALFOSC, which is provided by the Instituto de Astrofísica de Andalucía (IAA) under a joint agreement with the University of Copenhagen and NOT. E.L. was supported by Academy of Finland projects 317636 and 320045. Part of the French contribution is supported by the Scientific Research National Center (CNRS) and the French Spatial Agency (CNES). Some of the data are based on observations collected at the Observatorio de Sierra Nevada, owned and operated by the Instituto de Astrofísica de Andalucía (IAA-CSIC). Further data are based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA), operated jointly by Junta de Andalucía and Consejo Superior de Investigaciones Científicas (IAA-CSIC). D.B., S.K., R.S., and N. M. acknowledge support from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program under grant agreement No. 771282. C.C. acknowledges support by the European Research Council (ERC) under the HORIZON ERC Grants 2021 program under grant agreement No. 101040021. The Dipol-2 polarimeter was built in cooperation by the University of Turku, Finland, and the Leibniz Institut für Sonnenphysik, Germany, with support from the Leibniz Association grant SAW-2011-KIS-7. We are grateful to the Institute for Astronomy, University of Hawaii, for the allocated observing time. A.H. acknowledges The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This work was supported by JST, the establishment of university fellowships toward the creation of science technology innovation; grant No. JPMJFS2129. This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant Nos. JP21H01137. This work was also partially supported by Optical and Near-Infrared Astronomy Inter-University Cooperation Program from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).Peer reviewe

X-Ray Polarization of BL Lacertae in Outburst

Full list of authors: Peirson, Abel L.; Negro, Michela; Liodakis, Ioannis; Middei, Riccardo; Kim, Dawoon E.; Marscher, Alan P.; Marshall, Herman L.; Pacciani, Luigi; Romani, Roger W.; Wu, Kinwah; Di Marco, Alessandro; Di Lalla, Niccolo; Omodei, Nicola; Jorstad, Svetlana G.; Agudo, Ivan; Kouch, Pouya M.; Lindfors, Elina; Aceituno, Francisco Jose; Bernardos, Maria I.; Bonnoli, Giacomo; Casanova, Victor; Garcia-Comas, Maya; Agis-Gonzalez, Beatriz; Husillos, Cesar; Marchini, Alessandro; Sota, Alfredo; Casadio, Carolina; Escudero, Juan; Myserlis, Ioannis; Sievers, Albrecht; Gurwell, Mark; Rao, Ramprasad; Imazawa, Ryo; Sasada, Mahito; Fukazawa, Yasushi; Kawabata, Koji S.; Uemura, Makoto; Mizuno, Tsunefumi; Nakaoka, Tatsuya; Akitaya, Hiroshi; Cheong, Yeon; Jeong, Hyeon-Woo; Kang, Sincheol; Kim, Sang-Hyun; Lee, Sang-Sung; Angelakis, Emmanouil; Kraus, Alexander; Cibrario, Nicolo; Donnarumma, Immacolata; Poutanen, Juri; Tavecchio, Fabrizio; Antonelli, Lucio A.; Bachetti, Matteo; Baldini, Luca; Baumgartner, Wayne H.; Bellazzini, Ronaldo; Bianchi, Stefano; Bongiorno, Stephen D.; Bonino, Raffaella; Brez, Alessandro; Bucciantini, Niccolo; Capitanio, Fiamma; Castellano, Simone; Cavazzuti, Elisabetta; Chen, Chien-Ting; Ciprini, Stefano; Costa, Enrico; De Rosa, Alessandra; Del Monte, Ettore; Di Gesu, Laura; Doroshenko, Victor; Dovciak, Michal; Ehlert, Steven R.; Enoto, Teruaki; Evangelista, Yuri; Fabiani, Sergio; Ferrazzoli, Riccardo; Garcia, Javier A.; Gunji, Shuichi; Hayashida, Kiyoshi; Heyl, Jeremy; Iwakiri, Wataru; Kaaret, Philip; Karas, Vladimir; Kitaguchi, Takao; Kolodziejczak, Jeffery J.; Krawczynski, Henric; La Monaca, Fabio; Latronico, Luca; Madejski, Grzegorz; Maldera, Simone; Manfreda, Alberto; Marin, Frederic; Marinucci, Andrea; Massaro, Francesco; Matt, Giorgio; Mitsuishi, Ikuyuki; Muleri, Fabio; Ng, C. -Y.; O'Dell, Stephen L.; Oppedisano, Chiara; Papitto, Alessandro; Pavlov, George G.; Perri, Matteo; Pesce-Rollins, Melissa; Petrucci, Pierre-Olivier; Pilia, Maura; Possenti, Andrea; Puccetti, Simonetta; Ramsey, Brian D.; Rankin, John; Ratheesh, Ajay; Roberts, Oliver J.; Sgro, Carmelo; Slane, Patrick; Soffitta, Paolo; Spandre, Gloria; Swartz, Douglas A.; Tamagawa, Toru; Taverna, Roberto; Tawara, Yuzuru; Tennant, Allyn F.; Thomas, Nicholas E.; Tombesi, Francesco; Trois, Alessio; Tsygankov, Sergey; Turolla, Roberto; Vink, Jacco; Weisskopf, Martin C.; Xie, Fei; Zane, Silvia.--This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.We report the first >99% confidence detection of X-ray polarization in BL Lacertae. During a recent X-ray/γ-ray outburst, a 287 ks observation (2022 November 27–30) was taken using the Imaging X-ray Polarimetry Explorer (IXPE), together with contemporaneous multiwavelength observations from the Neil Gehrels Swift observatory and XMM-Newton in soft X-rays (0.3–10 keV), NuSTAR in hard X-rays (3–70 keV), and optical polarization from the Calar Alto and Perkins Telescope observatories. Our contemporaneous X-ray data suggest that the IXPE energy band is at the crossover between the low- and high-frequency blazar emission humps. The source displays significant variability during the observation, and we measure polarization in three separate time bins. Contemporaneous X-ray spectra allow us to determine the relative contribution from each emission hump. We find >99% confidence X-ray polarization {{\rm{\Pi }}}_{2\mbox{--}4\mathrm{keV}}={21.7}_{-7.9}^{+5.6} \% and electric vector polarization angle ψ2–4keV = −28fdg7 ± 8fdg7 in the time bin with highest estimated synchrotron flux contribution. We discuss possible implications of our observations, including previous IXPE BL Lacertae pointings, tentatively concluding that synchrotron self-Compton emission dominates over hadronic emission processes during the observed epochs. © 2023. The Author(s). Published by the American Astronomical Society.The Imaging X-ray Polarimetry Explorer (IXPE) is a joint US and Italian mission. The US contribution is supported by the National Aeronautics and Space Administration (NASA) and led and managed by its Marshall Space Flight Center (MSFC), with industry partner Ball Aerospace (contract NNM15AA18C). The Italian contribution is supported by the Italian Space Agency (Agenzia Spaziale Italiana, ASI) through contract ASI-OHBI-2017-12-I.0, agreements ASI-INAF-2017-12-H0 and ASI-INFN-2017.13-H0, and its Space Science Data Center (SSDC) with agreements ASI-INAF-2022-14-HH.0 and ASI-INFN 2021-43-HH.0, and by the Istituto Nazionale di Astrofisica (INAF) and the Istituto Nazionale di Fisica Nucleare (INFN) in Italy. This research used data products provided by the IXPE Team (MSFC, SSDC, INAF, and INFN) and distributed with additional software tools by the High-Energy Astrophysics Science Archive Research Center (HEASARC), at NASA Goddard Space Flight Center (GSFC). Funding for this work was provided in part by contract 80MSFC17C0012 from the MSFC to MIT in support of the IXPE project. Support for this work was provided in part by the NASA through the Smithsonian Astrophysical Observatory (SAO) contract SV3-73016 to MIT for support of the Chandra X-Ray Center (CXC), which is operated by SAO for and on behalf of NASA under contract NAS8-03060. The IAA-CSIC coauthors acknowledge financial support from the Spanish "Ministerio de Ciencia e Innovación" (MCIN/AEI/10.13039/501100011033) through the Center of Excellence Severo Ochoa award for the Instituto de Astrofíisica de Andalucía-CSIC (CEX2021-001131-S), and through grants PID2019-107847RB-C44 and PID2022-139117NB-C44. Some of the data are based on observations collected at the Observatorio de Sierra Nevada, owned and operated by the Instituto de Astrofísica de Andalucía (IAA-CSIC). Further data are based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA), operated jointly by Junta de Andalucía and Consejo Superior de Investigaciones Científicas (IAA-CSIC). The POLAMI observations were carried out at the IRAM 30 m Telescope. I.R.A.M. is supported by INSU/CNRS (France), MPG (Germany), and IGN (Spain). The Submillimetre Array is a joint project between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics and is funded by the Smithsonian Institution and the Academia Sinica. Maunakea, the location of the SMA, is a culturally important site for the indigenous Hawaiian people; we are privileged to study the cosmos from its summit. The data in this study include observations made with the Nordic Optical Telescope, owned in collaboration by the University of Turku and Aarhus University, and operated jointly by Aarhus University, the University of Turku, and the University of Oslo, representing Denmark, Finland, and Norway, the University of Iceland, and Stockholm University at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. The data presented here were obtained in part with ALFOSC, which is provided by the Instituto de Astrofísica de Andalucía (IAA) under a joint agreement with the University of Copenhagen and NOT. E.L. was supported by Academy of Finland projects 317636 and 320045. We acknowledge funding to support our NOT observations from the Finnish Centre for Astronomy with ESO (FINCA), University of Turku, Finland (Academy of Finland grant nr 306531). The research at Boston University was supported in part by National Science Foundation grant AST-2108622, NASA Fermi Guest Investigator grants 80NSSC21K1917 and 80NSSC22K1571, and NASA Swift Guest Investigator grant 80NSSC22K0537. This study used observations conducted with the 1.8 m Perkins Telescope Observatory (PTO) in Arizona (USA), which is owned and operated by Boston University. The above study is based in part on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA. We are grateful to the NuSTAR team for approving our DDT request. This work was supported under NASA contract No. NNG08FD60C, and made use of data from the NuSTAR mission, a project led by the California Institute of Technology, managed by the Jet Propulsion Laboratory, and funded by the NASA. This research has made use of the NuSTAR Data Analysis Software (NuSTARDAS) jointly developed by the ASI Science Data Center (ASDC, Italy) and the California Institute of Technology (USA). This work was supported by JST, the establishment of university fellowships toward the creation of science technology innovation, grant No. JPMJFS2129. This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant No. JP21H01137. This work was also partially supported by Optical and Near-Infrared Astronomy Inter-University Cooperation Program from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan. We are grateful to the observation and operating members of Kanata Telescope. M.N. acknowledges the support by NASA under award number 80GSFC21M0002. C.C. acknowledges support by the ERC under the Horizon ERC Grants 2021 program under grant agreement no. 101040021. S.K., S.-S.L., W.Y.C., S.-H.K., and H.-W.J. were supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST; 2020R1A2C2009003). The KVN is a facility operated by the Korea Astronomy and Space Science Institute. The KVN operations are supported by KREONET (Korea Research Environment Open NETwork), which is managed and operated by KISTI (Korea Institute of Science and Technology Information). Partly based on observations with the 100 m telescope of the MPIfR (Max-Planck-Institut für Radioastronomie) at Effelsberg. Observations with the 100 m radio telescope at Effelsberg have received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 101004719 (ORP). A.L.P. acknowledges support from NASA FINESST grant 80NSSC19K1407 and the Stanford Data Science Scholars program.Peer reviewe

13C=18O/15N isotope dependence of the amide-I/II 2D IR cross peaks for the fully extended peptides

We have used a combination of 2D IR spectroscopy with 13C=18O labeled amide-I and 15N-labeled amide-II modes to reveal how vibrational coupling between labeled peptide units depends on secondary structure. Linear and 2D IR measurements and simulations of Cα,α-diethylglycine homotetrapeptide show that this compound adopts the fully extended (2.05-helical) conformation in CDCl3, consistent with previous work on the Ac-capped peptide. The amide-I/II cross peaks of isotopomers exhibit only a marginal isotope frequency shift between labeled modes that are separated by two peptide units, indicating a very weak coupling. This result is in sharp contrast with a large cross-peak shift observed in 310-helical peptides, in which the labeled amide-I and -II modes are connected through an inter-residue C=O···H-N hydrogen bond. The discovered 3D-structural dependence indicates that the 13C=18O/15N labeled amide-I/II cross peaks can distinguish the formation of a single 310-helical turn from the fully extended polypeptide chain and increase the versatility of 2D IR spectroscopy as a conformational analysis tool of biomolecules

A Newtonian Model for the WASP-148 Exoplanetary System Enhanced with TESS and Ground-based Photometric Observations

The WASP-148 planetary system has a rare architecture with a transiting Saturn-mass planet on a tight orbit which is accompanied by a slightly more massive planet on a nearby outer orbit. Using new space-born photometry and ground-based follow-up transit observations and data available in literature, we performed modeling that accounts for gravitational interactions between both planets. Thanks to the new transit timing data for planet b, uncertainties of orbital periods and eccentricities for both planets were reduced relative to previously published values by a factor of 3-4. Variation in transit timing has an amplitude of about 20 min and can be easily followed-up with a 1-m class telescopes from the ground. An approximated transit ephemeris, which accounts for gravitational interactions with an accuracy up to 5 min, is provided. No signature of transits was found for planet c down to the Neptune-size regime. No other transiting companions were found down to a size of about 2.4 Earth radii for interior orbits. We notice, however, that the regime of terrestrial-size planets still remains unexplored in that system. © 2020 Copernicus Foundation for Polish Astronomy. All rights reserved.GM acknowledges the financial support from the National Science Centre, Poland through grant no. 2016/23/B/ST9/00579. MF acknowledges financial support from grant AYA2016-79425-C3-3-P of the Spanish Ministry of Economy and Competitiveness (MINECO), co-funded with EU FEDER funds, and grant PID2019-109522GB-C5X/AEI/10.13039/501100011033 of the Spanish Ministry of Science and Innovation (MICINN). This paper includes data collected with the TESS mission, obtained from the MAST data archive at the Space Telescope Science Institute (STScI). MF, AS, and AGS acknowledge financial support from the State Agency for Research of the Spanish MCIU through the Center of Excellence Severo Ochoa award to the Instituto de Astrofisica de Andalucia (SEV-2017-0709). Funding for the TESS mission is provided by the NASA Explorer Program. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. This research made use of Lightkurve, a Python package for Kepler and TESS data analysis (Lightkurve Collaboration, 2018). This research has made use of the SIMBAD database and the VizieR catalogue access tool, operated at CDS, Strasbourg, France, and NASA's Astrophysics Data System Bibliographic Services.Peer reviewe

Model Peptide Aggregates: the Role of Aromatic Interactions and Conformational Aspects

none5The aggregation propensities of two Ala-based pentapeptides [Py-CH2-CO-(L-Ala)5-OtBu (A5P) and Py-CH2-CO-(L-Ala)3- Aib-L-Ala-OtBu (A3UAP)], both functionalized with a pyrene (Py) aromatic chromophore at the N-terminus, have been investigated in methanol/water solvent mixtures by optical spectroscopies and in dried conditions by atomic force microscopy.noneM. Caruso;G. Ballano;F. Formaggio;C. Toniolo;M. VenanziM., Caruso; G., Ballano; Formaggio, Fernando; Toniolo, Claudio; M., Venanz

13C=18O/15N isotope dependence of the amide-I/II 2D IR cross peaks for the fully extended peptides

We have used a combination of 2D IR spectroscopy with 13C=18O labeled amide-I and 15N-labeled amide-II modes to reveal how vibrational coupling between labeled peptide units depends on secondary structure. Linear and 2D IR measurements and simulations of Cα,α-diethylglycine homotetrapeptide show that this compound adopts the fully extended (2.05-helical) conformation in CDCl3, consistent with previous work on the Ac-capped peptide. The amide-I/II cross peaks of isotopomers exhibit only a marginal isotope frequency shift between labeled modes that are separated by two peptide units, indicating a very weak coupling. This result is in sharp contrast with a large cross-peak shift observed in 310-helical peptides, in which the labeled amide-I and -II modes are connected through an inter-residue C=O···H-N hydrogen bond. The discovered 3D-structural dependence indicates that the 13C=18O/15N labeled amide-I/II cross peaks can distinguish the formation of a single 310-helical turn from the fully extended polypeptide chain and increase the versatility of 2D IR spectroscopy as a conformational analysis tool of biomolecules

C-13=O-18/N-15 Isotope Dependence of the Amide-I/II 2D IR Cross Peaks for the Fully Extended Peptides

We have used a combination of 2D IR spectroscopy with 13C=18O labeled amide-I and 15N-labeled amide-II modes to reveal how vibrational coupling between labeled peptide units depends on secondary structure. Linear and 2D IR measurements and simulations of Calpha,alpha-diethylglycine homotetrapeptide show that this compound adopts the fully extended (2.05-helical) conformation in CDCl3, consistent with previous work on the Ac-capped peptide. The amide-I/II cross peaks of isotopomers exhibit only a marginal isotope frequency shift between labeled modes that are separated by two peptide units, indicating a very weak coupling. This result is in sharp contrast with a large cross-peak shift observed in 3-10-helical peptides, in which the labeled amide-I and -II modes are connected through an inter-residue C=O...H-N hydrogen bond. The discovered 3D-structural dependence indicates that the 13C=18O/15N labeled amide-I/II cross peaks can distinguish the formation of a single 3-10-helical turn from the fully extended polypeptide chain and increase the versatility of 2D IR spectroscopy as a conformational analysis tool of biomolecules