Comparison of IL-23 receptor gene polymorphisms in patients with primary sjögren syndrome, ankylosing spondylitis. and ankylosing spondylitis with sjögren’s syndrome

Objectives: The frequency of Interleukin-23 receptor (IL-23R) gene polymorphism was previously studied in Ankylosing spondylitis (AS) and Sjögren syndrome (SS). However, it hasn’t been studied in patients AS with SS. Methods: The study included 124 patients with AS, 55 patients with SS and 12 patients with association of AS and SS. Results: It was found that there was an increase in the frequency of rs10889677 gene mutant genotype while a decrease in the frequency of in rs11209032 gene mutant genotype in AS group compared to the healthy controls. In SS group, it was found that there was an increase the frequencies of rs11805303 gene wild genotype and rs2201841 gene wild genotype while a decrease in the frequencies of rs11209032 gene heterozygote genotype and rs10489629 gene mutant genotype when compared to healthy controls. CGCAA haplotype was associated with risk for AS (P=0.0125; RR: 1.32). CGCAG haplotype was associated with protective effect against ankylosing spondylitis (P=0.0042; RR: 0.52). While CTCAA haplotype was found to be protective against SS (P=0.022; RR: 0.46), it was associated with increased risk for association of AS and SS (P=0.0095; RR: 2.79). CTCAG haplotype was associated with protective effect against association of AS and SS (P=0.0151; RR: 0.02). It was observed that TGCGG haplotype increased significantly in SS group compared to the healthy controls and that it was related with increased risk for SS (P=0.032, RR: 2.56). Conclusion: Genotype distribution and genetic diversity vary among ethnic groups. Studies with larger sample size are needed to further clarify this issue. © 2016, E-Century Publishing Corporation. All rights reserved

The nailfold videocapillaroscopy findings of Behçet's syndrome

Background: Nailfold videocapillaroscopy (NVC) is a diagnostic method for evaluating the microvasculature. Behçet's disease (BD) can affect vessels of all types and sizes. Methods: We performed NVC in 82 randomly selected patients with BD. NVC was performed for eight fingers (excluding the thumbs) with a 200× magnification. Results: Of the 82 patients with BD, 75 had at least one capillaroscopic change, including tortuosity in 75 (91.5%), bizarre capillaries in eight (9.8%), microhemorrhages in four (4.9%) and mega capillary in two (2.4%). The mean number of capillaries/mm length of nailfold in the group with BD was 10.17 ± 1.23 and was 11.45 ± 0.99 in the healthy controls (p < 0.001). Conclusion: In this study, the BD group had significantly more capillaroscopic pathological findings than did the healthy control group. However, the detected capillaroscopic pathology rate in BD patients was significantly lower than that of three previously published studies. Further studies are needed to clarify the diagnostic and prognostic value of capillaroscopy in BD

Assessment of damage and prognosis in patients with adult iga vasculitis: Retrospective multicentered cohort study

Bu çalışma, 14-17, Haziran 2017 tarihlerinde Madrid[İspanya]’da düzenlenen Annual European Congress of Rheumatology Kongresi‘nde bildiri olarak sunulmuştur

Cyclophosphamide induced bladder toxicity and protective effect of 2-mercaptoethane sulfonate (mesna) in systemic autoimmune disorders

WOS: 00033158790435

The management of gout in different clinical specialties in Turkey: a patient-based survey

Although gout is potentially curable, the management of this disease is often suboptimal. In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties. Three hundred and nineteen consecutive patients (mean age 58.60 ± 12.8 years; 44 females, 275 males) were included in this multicenter study. A standardized form was generated to collect data about the patient’s first admission to health care, the specialty of the doctor first diagnosed the gout, the treatment options for gout including attack management, patient referral, chronic treatment including medical treatment, and life style modifications. Forty patients were referred to another center without any treatment (12.8 %), and referral rate is most common among the primary care physicians (28.8 %). Colchicine was more commonly used for attack prophylaxis than allopurinol. Ninety-two patients had never been treated with allopurinol (28.8 %). Allopurinol prescription was less common among the primary care physicians and orthopedists, and highest among the rheumatologists. Recommendation of diet and life style modifications was less common among the primary care physicians and orthopedists, and highest among the rheumatologists. The rates of life style modification recommendation and long-term allopurinol prescription were 83.7 and 77.6 %, respectively, among the rheumatologists. Both acute and chronic management of gout is suboptimal in Turkey especially among the primary care physicians and orthopedists. Moreover, chronic treatment is even suboptimal among rheumatologists. © 2016, International League of Associations for Rheumatology (ILAR)