2 research outputs found
THU0116 European multicentre pilot survey to assess vitamin d and clinical status in rheumatoid arthritis patients
n/
European multicentre pilot survey to assess vitamin D status in rheumatoid arthritis patients and early development of a new Patient Reported Outcome questionnaire (D-PRO).
Objective: To collect data on vitamin D (25(OH)D) serum levels in a large number of rheumatoid arthritis (RA)
patients from different European countries, to investigate their relation with disease activity, disability, quality
of life, and possibly to construct a new Patient Reported Outcome (PRO) questionnaire in order to self-estimate
if they are at risk for vitamin D insufficiency/deficiency-related clinical implications (D-PRO).
Methods: This was a European League Against Rheumatism (EULAR) supported cross-sectional study (project No
CLI064) which involved 625 RA patients (mean age 55 \ub1 11 years, mean disease duration 11 \ub1 9 years), 276 age
and sex matched healthy subjects, and rheumatologists working in academic institutions or hospital centres, as
well as PARE organizations (patient representatives) from 13 European countries. Serum samples for 25(OH)D
level measurement were collected during winter time and analyzed in a central laboratory using chemiluminescence immunoassay (DiaSorin). Patient past medical history was recorded. RA patients were provided with three
questionnaires: the Rheumatoid Arthritis Impact Diseases score (RAID), the Health Assessment Questionnaire
(HAQ), and the new D-PRO questionnaire at the time of 25(OH)D serum sampling. D-PRO questionnaire
consisted of three domains, Symptom Risk Score (SRS), Habitus Risk Score (HRS) and Global Risk Score (SRS
+ HRS = GRS), constructed with items possibly related to vitamin D deficiency. D-PRO was correlated with
both clinical and PRO scores. DAS28-CRP was also evaluated. Statistical analysis was performed by non parametric test