Formation of an integrated system for monitoring the food security of the region

The agro-industrial complex at the current stage of operation requires a comprehensive analysis of the main directions of agricultural development and its development prospects, assessment of indicators determining the level of accessibility of food products - according to the global food security index, which allowed us to identify the main problems in ensuring the availability of food products. The subject of the study is the formation of an integrated system for monitoring food security in the agro-industrial complex of the region. The paper presents a comparative description of the methodological approaches to assessing the food security of the region. Indicators of the Russian Federation that are not fully synchronized with the main indicators of FAO food security have been identified. The aim and objective of the study is the introduction of progressive methodological approaches to assessing the physical accessibility of food products, which involves assessing the level of development of the distribution infrastructure taking into account the FAO system of food safety indicators, which allows an objective assessment of the volume of domestic production, determine the country's comparative advantages in the production of basic food products, and also evaluate the effectiveness of this production. The identified systemic threats to the food security of the region make it possible to justify the reserves for improving the functioning of the regional agri-food market. The necessity of applying a systematic approach to assessing the level of regional food security, which consists in consolidating the organizational, managerial, financial, economic and regulatory mechanisms for regulating the food security of the region, is substantiated. This will provide an information basis for determining development priorities and guidelines, identifying problems and threats in the food sector, taking into account regional characteristics, increasing the efficiency of forms and methods of food flow movement based on the use of effective management methods, the capabilities of modern information technologies and logistic ties

Chemo-Enzymatic Synthesis and Biological Evaluation of 5,6-Disubstituted Benzimidazole Ribo- and 2 '-Deoxyribonucleosides

A number of new 5,6-disubstituted benzimidazoles have been prepared and their substrate properties for recombinant E. coli purine nucleoside phosphorylase (PNP; the product of the deoD gene) in the transglycosylation reaction were investigated. The heterocyclic bases showed good substrate activity for PNP and the ribo- and 2-deoxyribonucleosides were synthesized. The predominant (OMe and OEt) or exclusive (Oi-Pr, morpholino, and N-methylpiperazino) formation of the 5-substituted 6-fluoro-1-(β-d- ribofuranosyl)benzimidazoles was observed. The formation of the regioisomeric 6- methoxy-, 6-ethoxy-, or 6-isopropoxy-substituted 1-(2-deoxy-β-d- ribofuranosyl)-5-fluorobenzimidazoles was observed in the trans-2- deoxyribosylation reaction of the corresponding bases. The predominant or exclusive formation of the regioisomeric N1-nucleosides with bulky 5-substituents of 6-fluorobenzimidazole points to a large hydrophobic pocket in the E. coli PNP active site that can accommodate these groups. The biological activity of the synthesized nucleosides was studied and revealed no inhibitory activity against a broad variety of DNA and RNA viruses. The compounds also lacked significant cytotoxicity. © Georg Thieme Verlag Stuttgart New York.status: publishe