Shape Optimisation of Curved Interconnecting Ducts

Practical ducting layout in process plants needs to satisfy a number of on-site constraints. The search for an optimal flow path around the obstructions is a multi-parameter problem and is computationally prohibitively expensive. In this study, authors proposed a rapid and efficient methodology for the optimal linkage of arbitrarily oriented fluid flow ducts using a single-parameter quadratic/cubic Bézier curves in two/three dimensions to describe the centreline of the curved duct. A smooth interconnecting duct can then be generated by extruding the duct face along the curve. By varying the parameter either along the angular bisector or along the axes of the ducts, a family of Bézier curves is generated. Computational fluid dynamics simulations show that the relationship between pressure drop and the adjustable parameter is a unimodal curve and the optimal connecting duct is the one which has the least pressure drop while satisfying on-site constraints can be used for linking the ducts. The efficacy of the method is demonstrated by applying it to some cases of practical interest.Defence Science Journal, Vol. 65, No. 4, July 2015, pp. 300-306, DOI: http://dx.doi.org/10.14429/dsj.65.8353

COMBINED EFFECT OF SELECTIVE BIOACTIVE COMPOUNDS FROM PLANT ORIGIN IN AN ANIMAL MODEL OF ANXIETY

Objective: Evidence is emerging that specific combinations of bioactive compounds may be far more effective in protecting against several diseases as compared to the effect of a single compound. The present study was aimed to investigate the interactive effect of Diosgenin and Silymarin, the bioactive compounds from plant origin in an animal model of anxiety. Methods: Albino wistar rats of either sex were divided into five groups and treated for 5 d. Group I and II served as control and standard and test groups were treated with Diosgenin (100 mg/kg, p. o.), Silymarin (100 mg/kg, p. o.) and combination of Diosgenin (50 mg/kg, p. o.)+Silymarin (50 mg/kg, p. o.), respectively. Diazepam (1 mg/kg, i. p.) was used as a standard for the study. Anxiolytic effects were studied in the Elevated plus-maze, Hole-board test and Light/Dark model. Results: The results suggested that Diosgenin when given alone at a dose of 100 mg/kg, does not shown significant anxiolytic effect when as compared with control. Whereas, the compound Silymarin (100 mg/kg) shown significant anti-anxiety effect (P<0.01), independently. The same two bioactive compounds, given in combination at a dose of 50 mg/kg, (each), exhibited significant anxiolytic-like effect, potentially. Conclusion: It can be concluded that Diosgenin has got a synergistic effect on anti-anxiety action when given in combination with Silymarin

Ride Dynamics of a Tracked Vehicle with a Finite Element Vehicle Model

Research on tracked vehicle dynamics is by and large limited to multi-rigid body simulation. For realistic prediction of vehicle dynamics, it is better to model the vehicle as multi-flexible body. In this paper, tracked vehicle is modelled as a mass-spring system with sprung and unsprung masses of the physical tracked vehicle by Finite element method. Using the equivalent vehicle model, dynamic studies are carried out by imparting vertical displacement inputs to the road wheels. Ride characteristics of the vehicle are captured by modelling the road wheel arms as flexible elements using Finite element method. In this work, a typical tracked vehicle test terrain viz., Trapezoidal blocks terrain (APG terrain) is considered. Through the simulations, the effect of the road wheel arm flexibility is monitored. Result of the analysis of equivalent vehicle model with flexible road wheel arms, is compared with the equivalent vehicle model with rigid road wheel arms and also with the experimental results of physical tracked vehicle. Though there is no major difference in the vertical bounce response between the flexible model and the rigid model, but there is a visible difference in the roll condition. Result of the flexible vehicle model is also reasonably matches with the experimental result.

Chemical Reaction and Hall Effects on MHD Convective Flow along an Infinite Vertical Porous Plate with Variable Suction and Heat Absorption

In this paper an attempt is made to study the chemical reaction and combined buoyancy effects of thermal and mass diffusion on MHD convective flow along an infinite vertical porous plate in the presence of Hall current with variable suction and heat generation. A uniform magnetic field is applied in a direction normal to the porous plate. The equations governing the fluid flow are solved using the perturbation technique and the expressions for the velocity, the temperature and the concentration distributions have been obtained. Dimensionless velocity, temperature and concentration profiles are displayed graphically for different values of the parameters entering into the problem like Prandtl number Pr, Hartmann number M, Grashof number G, modified Grashof number Gc, Hall parameter m, Heat source parameter δ, Schmidt number Sc, and Chemical reaction parameter Kr. The Skin-friction coefficient, rate of heat transfer and mass transfer at the plate have been obtained and also discussed through tables. It has been observed that an increase in the Prandtl number leads to a decrease in the primary and secondary velocities, and also a decrease in the primary and secondary temperatures. The primary and secondary velocities decrease with increase in the Chemical reaction parameter or Magnetic field parameter

Computational Analysis of Heat Transfer through Fins with Different Types of Notches

The Engine is one of the important component in an automobile which is subjected to high temperature and thermal stresses. In order to cool the engine the fins are another component which are used to dissipate the heat from the Engine. Fins are generally used to increase the heat transfer rate from the system to the surroundings. By doing computational flow analysis on the engine cooling fins, it is helpful to know about the heat dissipation rate and the Principle implemented in this project is to increase the heat transfer rate, so in this analysis, the fins are modified by putting different types of notches and are of same material. The knowledge of efficiency and effectiveness of the fins are necessary for proper designing of fins. The main objective of our analysis is to determine the flow of heat at various notches available and the analysis is done by using ANSYS – CFD Fluent software

Rosuvastatin plus fenofibrate in diabetic dyslipidemia: a hospital record based study

Background: Cardiovascular diseases (CVD) are the leading cause of death throughout world population each and every year. Focus on dyslipidemia management is urgently required in India to halt the rising tide of CVD. The purpose of diabetic dyslipidemia study is a record based one, to find out the effect of Rosuvastatin plus Fenofibrate, in adult Type 2 diabetes with dyslipidemia, with high TGL/HDL ratio in Lipid profiles, in a tertiary care hospital in the Union territory of Puducherry.Methods: There were 101 patients hospital records were analysed in which male were 45 and females were 56. The various biochemical parameters like serum Total Cholesterol, HDL, LDL, TGL, Non-HDL, TCL/HDL Ratio and TGL/HDL ratio reports were collected before and after 12-weeks of Rosuvastatin 10 mg with Fenofibrate 145 mg combination, for the treatment period once daily for their lipid-lowering therapy.Results: The combination therapies of Rosuvastatin plus Fenofibrate were safe and feasible to achieve more TG goal and proved that has predominately decreased the elevated lipid profiles from the medical resources of our record based study. The use of combination medications of rosuvastatin (10mg) plus Fenofibrate (145mg) is often needed to effectively treat the lipid triad, by the potency of rosuvastatin to lower LDL-C and Fenofibrates effectiveness in lowering TG in treating mixed diabetic dyslipidemia.Conclusions: After Rosuvastatin (10mg) plus Fenofibrate (145mg), the lipid profile data proved that the importance of TGL/HDL ratio apart from the TCL/HDL ratio, for good lipid control in diabetic dyslipidemic patients

Pattern of adverse effects in patients with nephrotic syndrome on oral prednisolone

Background: Nephrotic syndrome is a common illness affecting the paediatric age group and 80% of the idiopathic syndrome is steroid sensitive. Multiple relapses make them vulnerable to the adverse effects of corticosteroids. There is limited literature evidence for the adverse effects of steroids in children with renal pathology.Methods: This descriptive, cross sectional study analyses the adverse effects of oral prednisolone in children and adults with nephrotic syndrome Fifty-five patients with nephrotic syndrome, attending nephrology or paediatric OP, more than 3 years of age and who were on oral prednisolone for a minimum of eight weeks were included in the study. Demographic details, detailed history, lab investigations and ophthalmic examination were done and the results were analysed.Results: Hypertension and behavioural changes were the most common adverse effects followed by dermatological, endocrine and metabolic changes. Infections and gastrointestinal disturbances were more in adults (p <0.05). Short stature was more in children (p< 0.05). There was no abnormality in blood glucose levels and body weight. Hypertension, cushingoid habitus, infections and short stature were statistically less in patients on alternate day prednisolone. But no statistical association could be made between the occurrence of cataract and the pattern of prednisolone use.Conclusions: Adverse effects pattern is different among adults and children. Also, the adverse effects are less with alternate day prednisolone regimen. Long term follow up into their adulthood is needed to analyse the morbidity produced by corticosteroids in these subsets of population

(E)-4-Bromo-2-[(2,6-diisopropyl­phen­yl)imino­meth­yl]phenol

In the title compound, C19H22BrNO, the dihedral angle between the benzene rings is 76.17 (14)° and an intra­molecular O—H⋯N hydrogen bond with an S(6) graph-set motif is present. One methyl group is disordered over two sets of sites with site occupancies of 0.66 (3) and 0.34 (3). A weak inter­molecular C—H⋯π inter­action is observed in the crystal structure