Çalışanların iş tatmin düzeylerinin incelenmesi (Muğla Orman Bölge Müdürlüğü örneği)

Günümüz çalışma hayatında iş tatmininin artan önemi ve ormancılık sektöründeki çalışmaların yetersizliği, bu çalışmanın ortaya çıkışındaki başlıca nedenlerdir. Çalışmanın amacı, yöneticilerin tatmin düzeylerini belirlemek ve böylece gereken tedbirlerin alınabilmesi için öneriler sunmaktır. Çalışmada veri elde etmek için anket yönteminden yararlanılmıştır. Verilerin değerlendirilmesi için bağımsız iki örnek t-testi ve tek yönlü varyans analizi kullanılmıştır. Çalışanların, işin niteliği ve çalışma koşullarına, çalışma arkadaşlarına ve iletişim ve kurum imajına ilişkin tatmin düzeyleri yüksek çıkmıştır. Çalışanların en fazla tatminsizlik duydukları faktörün ücret olduğu ve yaş ilerledikçe ücrete bağlı tatminsizliğin arttığı bulunmuştur. Çalışanların iş tatmin düzeylerini arttırmak için daha iyi ücret politikaları uygulanmalı ve sosyal imkânlar iyileştirilmelidir. Anahtar Kelimeler: İş tatmini, Varyans analizi, Orman Bölge Müdürlüğü, Muğl

Exhibition / Sergi

6 Aralık 2013 tarihinde ODTÜ Mimarlık Fakültesi Sergi Salonunda açılan sergide, Raci Bademli’nin yürütmüş olduğu önemli proje çalışmaları sergilenmektedir. Sergi, 1986 tarihli ‘Ulus Tarihi Kent Merkezi Düzenleme Yarışması Projesi”, 1989 tarihli ‘Ulus Tarihi Kent Merkezi Koruma Islah İmar Planı’, 2002 tarihli ‘Hacıbayram Camisi Çevresi Kamu Proje Alanı Kentsel Tasarım Planı’ ve 2001-2002 tarihli ‘Gelibolu Yarımadası Tarihi Milli Parkı-Barış Parkı Uzun Devreli Gelişme Planı’ndan oluşmaktadırPublisher's Versio

A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

Evran, Serap/0000-0001-6676-4888; Aydindogan, Eda/0000-0003-4882-6445; BALABAN, Simge/0000-0002-4540-1882WOS: 000505735900018PubMed: 31581533Aptamer-based point-of-care (POC) diagnostics platforms may be of substantial benefit in forensic analysis as they provide rapid, sensitive, user-friendly, and selective analysis tools for detection. Aptasensors have not yet been adapted commercially. However, the significance of the applications of aptasensors in the literature exceeded their potential. Herein, in this review, a bottom-up approach is followed to describe the aptasensor development and application procedure, starting from the synthesis of the corresponding aptamer sequence for the selected analyte to creating a smart surface for the sensitive detection of the molecule of interest. Optical and electrochemical biosensing platforms, which are designed with aptamers as recognition molecules, detecting abused drugs are critically reviewed, and existing and possible applications of different designs are discussed. Several potential disciplines in which aptamer-based biosensing technology can be of greatest value, including forensic drug analysis and biological evidence, are then highlighted to encourage researchers to focus on developing aptasensors in these specific areas.Republic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2016K121190]Researches were funded by the Republic of Turkey, Ministry of Development, grant number 2016K121190

Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection

In recent years, magnetic nanoparticles (MNPs) have been widely used in many fields due to their advantageous properties, such as biocompatibility, easy modifiability, and high chemical stability. One of these areas is the detection of cancer. It is essential to use existing biomarkers, such as microRNAs (miRNAs), for the early diagnosis of this disease. miRNAs are challenging to distinguish and detect in biological samples because they are small, circulating molecules. It is necessary to use more sensitive and feature-rich systems. Thanks to their large surface areas and magnetic moments, MNPs allow easy separation of miRNA at low concentrations from complex samples (urine and blood) and rapid and specific detection in biosensing systems. Here, we discussed the synthesis and characterization methods of MNPs, their stabilization, and MNP-based biosensors in terms of miRNA detection. We considered the challenges and prospects of these biosensor systems in evaluating the development stages, sensitivity, and selectivity

Synthetic antibodies for methamphetamine analysis: Design of high affinity aptamers and their use in electrochemical biosensors

An aptamer-based electrochemical biosensor was designed and fabricated for methamphetamine (METH) anal-ysis. Several aptamer sequences developed by the GO-SELEX method were immobilized onto gold electrodes (GE) via gold-thiol affinity. Surface characterizations were performed by electrochemical methods including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectrometry (EIS). GE/Apta-4/METH aptasensor was selected for further studies since the best results were obtained with the Apta-4 sequence in terms of analytical parameters. Accordingly, it exhibited good selectivity for METH analysis with a wide linear range of 0.1-50 ng/mL and a low limit of detection (LOD) which was found to be 0.467 ng/mL. The proposed aptasensor platform displayed good selectivity for the detection of METH in synthetic urine samples spiked with METH.This work was supported by the Republic of Turkey, Ministry of Development (Project Grant No: 2016 K121190) and partially by Ege University Scienti fi c Research Projects Coordination Unit (Project Grant No: 18 -FEN -006) . We thank Ege University Central Research Testing and Analysis Laboratory Research and Application Center (EGE-MATAL) for ITC measurements.Republic of Turkey, Ministry of Development [2016 K121190]; Ege University Scienti fi c Research Projects Coordination Unit [18 -FEN -006

Elevated Circulating Endocan Levels Are Associated with Increased Levels of Endothelial and Inflammation Factors in Postprandial Lipemia

Background: Postprandial lipemia (PPL) causes endothelial dysfunction by causing endothelial damage to lipoproteins that remain rich in triglycerides. Endocan is a proteoglycan with increased tissue expression, endothelial activation, and neovascularization. The aim of the study was to examine circulating endocan levels in PPL subjects by considering the degree of PPL response according to a high-fat test meal. The other aim was to determine the association between endocan levels and endothelial and inflammatory factors. Method: Fifty-four hyperlipidemic subjects and 28 normolipidemic subjects consumed the high-fat meal. Endocan, sICAM-1, sVCAM-1, and VEGFA as endothelial factors and IL-6 and LFA-1α as inflammatory factors were evaluated. Results: Fasting serum endocan, VEGFA, sICAM-1, sVCAM-1 IL-6, and LFA-1α levels were increased in the PPL group compared to the control group. The PPL group was divided into tertiles based on mean AUC levels. Endocan levels in tertile 3 were at the highest and were increased significantly compared to tertiles 1 and 2. AUC and endocan levels were positively correlated with other endothelial and inflammation factors. ROC analysis showed endocan levels to be one of the highest values. Conclusions: Circulating endocan is seen at significantly higher levels and independently associated with endothelial and inflammatory factors in postprandial lipemia and dyslipidemia

The effects of N-acetylcysteine on microsomal and serum paraoxonase 1 activities at high fat diet induced obese rats

41st FEBS Congress on Molecular and Systems Biology for a Better Life -- SEP 03-08, 2016 -- Kusadasi, TURKEYWOS: 000383616901816…FEB

Short-Term Standard Diet Consumption Prior to the Oral Fat Tolerance Test Modulates the Postprandial Triglyceride Response

We hypothesized that the consumption of a 3-day standard diet (SD) prior to the oral fat tolerance test (OFTT), used to evaluate postprandial lipemia, may counteract the undesirable effects of individual dietary habits on the test results. The OFTT was applied to 22 healthy adults (11 females and 11 males), after their habitual diets (HDs) and following the consumption of a 3-day SD (45–60% energy from carbohydrate, 20–35% from fat, and 10–20% from protein). Plasma triglyceride (TG) concentrations were measured during fasting and at the fourth hour of the OFTT. A 3-day SD significantly reduced fasting and fourth-hour TG concentrations and delta TG values by 10%, 12.8%, and 22.7%, respectively. Decreases were observed in fasting and fourth-hour TG and delta TG values following the 3-day SD compared to the HD in subjects with fasting TG concentrations between 89 and 180 mg/dL (p = 0.062, p = 0.018, and 0.047, respectively). As a result, the consumption of a 3-day standardized diet prior to the OFTT may be useful to eliminate the false positive or negative effects of individual dietary habits on test results and to correctly identify individuals who should be administered the OFTT