249 research outputs found
Long-range transfer of electron-phonon coupling in oxide superlattices
The electron-phonon interaction is of central importance for the electrical
and thermal properties of solids, and its influence on superconductivity,
colossal magnetoresistance, and other many-body phenomena in
correlated-electron materials is currently the subject of intense research.
However, the non-local nature of the interactions between valence electrons and
lattice ions, often compounded by a plethora of vibrational modes, present
formidable challenges for attempts to experimentally control and theoretically
describe the physical properties of complex materials. Here we report a Raman
scattering study of the lattice dynamics in superlattices of the
high-temperature superconductor and the
colossal-magnetoresistance compound that suggests
a new approach to this problem. We find that a rotational mode of the MnO
octahedra in experiences pronounced
superconductivity-induced lineshape anomalies, which scale linearly with the
thickness of the layers over a remarkably long range of
several tens of nanometers. The transfer of the electron-phonon coupling
between superlattice layers can be understood as a consequence of long-range
Coulomb forces in conjunction with an orbital reconstruction at the interface.
The superlattice geometry thus provides new opportunities for controlled
modification of the electron-phonon interaction in complex materials.Comment: 13 pages, 4 figures. Revised version to be published in Nature
Material
Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy
The prevalence of food allergy has increased over the last 20-30 years, including cow milk allergy (CMA) which is one of the most common causes of infant food allergy. International allergy experts met in 2019 to discuss broad topics in allergy prevention and management of CMA including current challenges and future opportunities. The highlights of the meeting combined with recently published developments are presented here. Primary prevention of CMA should start from pre-pregnancy with a focus on a healthy lifestyle and food diversity to ensure adequate transfer of inhibitory IgG- allergen immune complexes across the placenta especially in mothers with a history of allergic diseases and planned c-section delivery. For non-breastfed infants, there is controversy about the preventive role of partially hydrolyzed formulae (pHF) despite some evidence of health economic benefits among those with a family history of allergy. Clinical management of CMA consists of secondary prevention with a focus on the development of early oral tolerance. The use of extensive Hydrolysate Formulae (eHF) is the nutrition of choice for the majority of non-breastfed infants with CMA; potentially with pre-, probiotics and LCPUFA to support early oral tolerance induction. Future opportunities are, among others, pre- and probiotics supplementation for mothers and high-risk infants for the primary prevention of CMA. A controlled prospective study implementing a step-down milk formulae ladder with various degrees of hydrolysate is proposed for food challenges and early development of oral tolerance. This provides a more precise gradation of milk protein exposure than those currently recommended
The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity
Mentha species are medicinally used worldwide and remain attractive for research due to the diversity of their phytoconstituents and large therapeutic indices for various ailments. This study used the metabolomics examination of five Mentha species (M. suaveolens, M. sylvestris, M. piperita, M. longifolia, and M. viridis) to justify their cytotoxicity and their anti-Helicobacter effects. The activities of species were correlated with their phytochemical profiles by orthogonal partial least square discriminant analysis (OPLS-DA). Tentatively characterized phytoconstituents using liquid chromatography high-resolution electrospray ionization mass spectrometry (LC-HR-ESI-MS) included 49 compounds: 14 flavonoids, 10 caffeic acid esters, 7 phenolic acids, and other constituents. M. piperita showed the highest cytotoxicity to HepG2 (human hepatoma), MCF-7 (human breast adenocarcinoma), and CACO2 (human colon adenocarcinoma) cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. OPLS-DA and dereplication studies predicted that the cytotoxic activity was related to benzyl glucopyranoside-sulfate, a lignin glycoside. Furthermore, M. viridis was effective in suppressing the growth of Helicobacter pylori at a concentration of 50 mg mL−1. OPLS-DA predicted that this activity was related to a dihydroxytrimethoxyflavone. M. viridis extract was formulated with Pluronic® F127 to develop polymeric micelles as a nanocarrier that enhanced the anti-Helicobacter activity of the extract and provided minimum inhibitory concentrations and minimum bactericidal concentrations of 6.5 and 50 mg mL−1, respectively. This activity was also correlated to tentatively identified constituents, including rosmarinic acid, catechins, carvone, and piperitone oxide
Quantum Computing and Quantum Simulation with Group-II Atoms
Recent experimental progress in controlling neutral group-II atoms for
optical clocks, and in the production of degenerate gases with group-II atoms
has given rise to novel opportunities to address challenges in quantum
computing and quantum simulation. In these systems, it is possible to encode
qubits in nuclear spin states, which are decoupled from the electronic state in
the S ground state and the long-lived P metastable state on the
clock transition. This leads to quantum computing scenarios where qubits are
stored in long lived nuclear spin states, while electronic states can be
accessed independently, for cooling of the atoms, as well as manipulation and
readout of the qubits. The high nuclear spin in some fermionic isotopes also
offers opportunities for the encoding of multiple qubits on a single atom, as
well as providing an opportunity for studying many-body physics in systems with
a high spin symmetry. Here we review recent experimental and theoretical
progress in these areas, and summarise the advantages and challenges for
quantum computing and quantum simulation with group-II atoms.Comment: 11 pages, 7 figures, review for special issue of "Quantum Information
Processing" on "Quantum Information with Neutral Particles
Giant phonon anomalies and central peak due to charge density wave formation in YBaCuO
The electron-phonon interaction is a major factor influencing the competition
between collective instabilities in correlated-electron materials, but its role
in driving high-temperature superconductivity in the cuprates remains poorly
understood. We have used high-resolution inelastic x-ray scattering to monitor
low-energy phonons in YBaCuO (superconducting
K), which is close to a charge density wave (CDW) instability. Phonons in a
narrow range of momentum space around the CDW ordering vector exhibit extremely
large superconductivity-induced lineshape renormalizations. These results imply
that the electron-phonon interaction has sufficient strength to generate
various anomalies in electronic spectra, but does not contribute significantly
to Cooper pairing. In addition, a quasi-elastic "central peak" due to CDW
nanodomains is observed in a wide temperature range above and below ,
suggesting that the gradual onset of a spatially inhomogeneous CDW domain state
with decreasing temperature is a generic feature of the underdoped cuprates
Multi-orbital and density-induced tunneling of bosons in optical lattices
We show that multi-orbital and density-induced tunneling have a significant
impact on the phase diagram of bosonic atoms in optical lattices. Off-site
interactions lead to density-induced hopping, the so-called bond-charge
interactions, which can be identified with an effective tunneling potential and
can reach the same order of magnitude as conventional tunneling. In addition,
interaction-induced higher-band processes also give rise to strongly modified
tunneling, on-site and bond-charge interactions. We derive an extended
occupation-dependent Hubbard model with multi-orbitally renormalized processes
and compute the corresponding phase diagram. It substantially deviates from the
single-band Bose-Hubbard model and predicts strong changes of the superfluid to
Mott-insulator transition. In general, the presented beyond-Hubbard physics
plays an essential role in bosonic lattice systems and has an observable
influence on experiments with tunable interactions.Comment: 21 pages, 7 figure
Edge stabilization in reduced-dimensional perovskites
Reduced-dimensional perovskites are attractive light-emitting materials due to their efficient luminescence, color purity, tunable bandgap, and structural diversity. A major limitation in perovskite light-emitting diodes is their limited operational stability. Here we demonstrate that rapid photodegradation arises from edge-initiated photooxidation, wherein oxidative attack is powered by photogenerated and electrically-injected carriers that diffuse to the nanoplatelet edges and produce superoxide. We report an edge-stabilization strategy wherein phosphine oxides passivate unsaturated lead sites during perovskite crystallization. With this approach, we synthesize reduced-dimensional perovskites that exhibit 97 ± 3% photoluminescence quantum yields and stabilities that exceed 300 h upon continuous illumination in an air ambient. We achieve green-emitting devices with a peak external quantum efficiency (EQE) of 14% at 1000 cd m-2; their maximum luminance is 4.5 × 104 cd m-2 (corresponding to an EQE of 5%); and, at 4000 cd m-2, they achieve an operational half-lifetime of 3.5 h.This publication is based in part on work supported by an award (KUS-11-009-21) from the King Abdullah University of Science and Technology (KAUST), by the Ontario Research Fund Research Excellence Program, by the Ontario Research Fund (ORF), by the Natural Sciences and Engineering Research Council (NSERC) of Canada, and by the US Department of Navy, Office of Naval Research (Grant Award No. N00014-17-1-2524). H.Y. acknowledges the Research Foundation-Flanders (FWO Vlaanderen) for a postdoctoral fellowship. E.B. gratefully acknowledges financial support by the Research Foundation-Flanders (FWO Vlaanderen). S.B. acknowledges financial support from European Research Council (ERC Starting Grant #815128-REALNANO). M.B.J.R. and J.H. acknowledge the Research Foundation-Flanders (FWO, Grants G.0962.13, G.0B39.15, AKUL/11/14 and G0H6316N), KU Leuven Research Fund (C14/15/053) and the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. [307523], ERC-Stg LIGHT to M.B.J.R. DFT calculations were performed on the IBM BlueGene Q supercomputer with support from the Southern Ontario Smart Computing Innovation Platform (SOSCIP). M.I.S. acknowledges the Banting Postdoctoral Fellowship program from the Natural Sciences and Engineering Research Council of Canada (NSERC). H.T. acknowledges the Netherlands Organisation for Scientific Research (NWO) for a Rubicon grant (680-50-1511)
Quantum computing implementations with neutral particles
We review quantum information processing with cold neutral particles, that
is, atoms or polar molecules. First, we analyze the best suited degrees of
freedom of these particles for storing quantum information, and then we discuss
both single- and two-qubit gate implementations. We focus our discussion mainly
on collisional quantum gates, which are best suited for atom-chip-like devices,
as well as on gate proposals conceived for optical lattices. Additionally, we
analyze schemes both for cold atoms confined in optical cavities and hybrid
approaches to entanglement generation, and we show how optimal control theory
might be a powerful tool to enhance the speed up of the gate operations as well
as to achieve high fidelities required for fault tolerant quantum computation.Comment: 19 pages, 12 figures; From the issue entitled "Special Issue on
Neutral Particles
Clinical presentations and outcomes of Filipino juvenile systemic lupus erythematosus
<p>Abstract</p> <p>Objective</p> <p>Juvenile Systemic Lupus Erythematosus (SLE) varies by location and ethnicity. This study describes the clinical, laboratory profile and outcome of juvenile SLE seen at Philippine General Hospital (PGH) from 2004-2008.</p> <p>Method</p> <p>Medical charts of all Filipino Juvenile SLE cases admitted at PGH during the 5-year period were reviewed collecting demographic profile, clinical and laboratory manifestations and treatment during disease course.</p> <p>Results</p> <p>Seventy-eight cases of juvenile SLE were reviewed. There were 7 boys and 71 girls. The mean age at diagnosis was 14 years (SD 2.7) with a range of 8-18 years. Fever (52.5%) and malar rash (41.0%) were the most common features at disease onset. At the time of diagnosis, the most common features were malar rash (65.3%), renal involvement (62.8%) and photosensitivity (55.1%). Mucocutaneous (92.3%), renal (71.7%) and hematologic (69.2%) involvement were the most common features during the entire course of illness. Infection (34.5%) and neurologic (19.0%) complications were observed most frequently. Corticocosteroid treatment was given in most of the patients in the form of prednisone (97.4%) and concomitant methylprednisolone intravenous pulses (29.4%). Nine patients died during the study period. The overall 5-year mortality rate was 11.5%. Infection (77.0%) was the most frequent cause of death.</p> <p>Conclusion</p> <p>Malar rash was a common feature at disease onset and at diagnosis among Filipinos with juvenile SLE. Throughout the disease course, renal involvement occurs in 71.7% of patients. Infection was the leading cause of complication and death. The clinical presentations of Filipinos with juvenile SLE were similar to juvenile SLE in other countries.</p
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