Analisis Pendapatan Usaha Kerajinan Tempurung Kelapa di Desa Bakka – Bakka Kecamatan Wonomulyo Kabupaten Polewali Mandar

Penelitian ini dilaksanakan pada Usaha Kerajinan Tempurung Kelapa Di Desa Bakka-Baka, Kecamatan Wonomulyo, Kabupaten Polewali Mandar yang berlangsung selama 3 bulan yaitu bulan April sampai dengan bulan Juni 2016. Penelitian ini bertujuan untuk mengetahui berapa besar pendapatan yang diterima serta untuk mengetahui nilai R/C Ratio yang diperoleh dari USAha kerajinan tempurung kelapa. Penentuan lokasi penelitian ini menggunakan metode purposive yaitu tehnik penentuan sampel dengan pertimbangan tertentu. metode yang digunakan adalah metode observasi, wawancara (dengan Quesioner yang telah disiapkan), dan dokumentasi. Dilanjutkan dengan pengolahan data dengan menggunakan metode analisis kuantitatif untuk menentukan berapa besar pendapatan dan nilai R/C Ratio yang diperoleh dari USAha kerajinan tempurung kelapa yang dijalankan. Hasil penelitian menunjukan bahwa rata-rata pendapatan perbulan yang diperoleh dari USAha kerajinan tempurung kelapa adalah sebesar Rp. 347.333,- dari total penerimaan sebesar Rp 1.320.00,- dan total biaya sebesar Rp. 972.667,- sedangkan nilai R/C Ratio yang diperoleh sebesar Rp. 1,36 artinya setiap penambahan biaya Rp. 1,- maka akan memperoleh penerimaan sebesar Rp. 1,36,- sehingga USAha kerajinan tempurung kelapa dikatakan layak (untung) sehingga dapat dijalankan dan dikembangkan

Attitudes of Students at Sultan Qaboos University towards the Nursing Profession

Objectives: The aim of this study was to explore the attitudes of Sultan Qaboos University (SQU) students towards the nursing profession. Methods: A sample of 377 students (male = 130; female = 247) were selected from different colleges of SQU, including the College of Nursing. A questionnaire was constructed and validated to assess the attitudes of SQU students towards the nursing profession. Results: Findings revealed that both male and female students in all academic years and colleges had positive attitudes toward the nursing profession. The findings also revealed that gender and academic year created no significant differences (P <0.05) among the study participants, but that the students’ college affiliation did have a significant effect on their attitudes. In particular, nursing students had more positive attitudes than students of other colleges. Conclusion: Findings indicated that the attitudes of SQU students towards the nursing profession were positive, especially those of the nursing students. This means that serious efforts should be made to continue to promote the nursing profession and so ensure that it remains positively regarded by all concerned

Karakteristik Alterasi dan Mineralisasi Hidrotermal Daerah Hulawa, Gorontalo, Indonesia

Gold is one of the precious metals with high economic value, so the exploration process becomes an important stage to find new resources so that gold production remains optimal. The research was aimed at investigating the geological condition and characteristics of hydrothermal alteration and mineralization developed in the research site. The research site was included in the area CoW of PT. Gorontalo Sejahtera Mining exactly lied in Hulawa Village, Gorontalo, Indonesia. This research integrated the fieldwork with laboratory tests and analysis, including petrography, Analytical Spectral Devices, and mineragraphy. Based on data that had been conducted and data analysis results, it can be concluded that the research site consisted of lithology in the form of Oligocene granodiorite and Pliocene rhyodacite and diatreme breccia that rolled as host rock\u27s mineralization. Normal right-slip fault directing E-W is interpreted as a pre-mineralization structure, while normal left-slip fault directing NNE-SSW is interpreted as syn-mineralization structure or controlling structure during alteration and mineralization process. Alteration developed in research area consisted of the phyllic zone (sericite + quartz ± pyrite ± montmorillonite ± chlorite ± carbonate), argillic zone (illite + kaolinite ± smectite ± montmorilonite), and chloritic zone (chlorite + carbonate + pyrite ± quartz ± illite ± sericite ± montmorillonite). Hydrothermal deposits controlled by geological structure and volcanic mechanism. Mineralization in the research site was found in stockwork quartz veins and hydrothermal breccia, and some were found in dissemination with ores such as pyrite, chalcopyrite, arsenopyrite, galena, sphalerite, bornite, covelite, gold, and electrum. Based on its alteration and mineralization characteristics, the epithermal deposits in the research site was the type of low sulphidation deposite in-depth level in the model of open-vein and breccia

Karakteristik Alterasi dan Mineralisasi Hidrotermal Daerah Hulawa, Gorontalo, Indonesia

Gold is one of the precious metals with high economic value, so the exploration process becomes an important stage to find new resources so that gold production remains optimal. The research was aimed at investigating the geological condition and characteristics of hydrothermal alteration and mineralization developed in the research site. The research site was included in the area CoW of PT. Gorontalo Sejahtera Mining exactly lied in Hulawa Village, Gorontalo, Indonesia. This research integrated the fieldwork with laboratory tests and analysis, including petrography, Analytical Spectral Devices, and mineragraphy. Based on data that had been conducted and data analysis results, it can be concluded that the research site consisted of lithology in the form of Oligocene granodiorite and Pliocene rhyodacite and diatreme breccia that rolled as host rock\u27s mineralization. Normal right-slip fault directing E-W is interpreted as a pre-mineralization structure, while normal left-slip fault directing NNE-SSW is interpreted as syn-mineralization structure or controlling structure during alteration and mineralization process. Alteration developed in research area consisted of the phyllic zone (sericite + quartz ± pyrite ± montmorillonite ± chlorite ± carbonate), argillic zone (illite + kaolinite ± smectite ± montmorilonite), and chloritic zone (chlorite + carbonate + pyrite ± quartz ± illite ± sericite ± montmorillonite). Hydrothermal deposits controlled by geological structure and volcanic mechanism. Mineralization in the research site was found in stockwork quartz veins and hydrothermal breccia, and some were found in dissemination with ores such as pyrite, chalcopyrite, arsenopyrite, galena, sphalerite, bornite, covelite, gold, and electrum. Based on its alteration and mineralization characteristics, the epithermal deposits in the research site was the type of low sulphidation deposite in-depth level in the model of open-vein and breccia

Down's Syndrome with Alzheimer's Disease-Like Pathology: What Can It Teach Us about the Amyloid Cascade Hypothesis?

Down's syndrome (DS, trisomy 21) represents a complex genetic abnormality that leads to pathology in later life that is similar to Alzheimer's disease (AD). We compared two cases of DS with APOE ε3/3 genotypes, a similar age at death, and comparable amyloid-beta 42 peptide (Aβ42) burdens in the brain but that differed markedly in the severity of AD-like pathology. One exhibited extensive neurofibrillary pathology whereas the other showed minimal features of this type. Comparable loads of Aβ42 could relate to the cases' similar life-time accumulation of Aβ due to trisomy 21-enhanced metabolism of amyloid precursor protein (APP). The cases' significant difference in AD-like pathology, however, suggests that parenchymal deposition of Aβ42, even when extensive, may not inevitably trigger AD-like tau pathology (though it may be necessary). Thus, these observations of a natural experiment may contribute to understanding the nuances of the amyloid cascade hypothesis of AD pathogenesis

Dynamic characterisation of a heritage structure with limited accessibility using ambient vibrations

Historic Cairo has been a UNESCO World Heritage Site since 1979. It has more than 600 historic structures, which require extensive studies to sustain their cultural, religious, and economic values. The main aim of this paper is to undertake dynamic investigation tests for the dome of Fatima Khatun, a historic mausoleum in Historic Cairo dating back to the 13th century and consisting of mainly bricks and stones. The challenge was that the structure was difficult to access, and only a small portion of the top was accessible for the attachment of accelerometers. Current dynamic identification procedures typically adopt methods in which the sensors are arranged at optimal locations and permit direct assessment of the natural frequencies, mode shapes, and damping ratios of a structure. Approaches that allow for the evaluation of dynamic response for structures with limited accessibility are lacking. To this end, in addition to in situ dynamic investigation tests, a numerical model was created based on available architectural, structural, and material documentation to obtain detailed insight into the dominant modes of vibration. The free vibration analysis of the numerical model identified the dynamic properties of the structure using reasonable assumptions on boundary conditions. System identification, which was carried out using in situ dynamic investigation tests and input from modelling, captured three experimental natural frequencies of the structure with their mode shapes and damping ratios. The approach proposed in this study informs and directs structural restoration for the mausoleum and can be used for other heritage structures located in congested historic sites

IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

Nuclear factor κB (NF-κB) is involved in multiple skeletal muscle disorders, but how it functions in differentiation remains elusive given that both anti- and promyogenic activities have been described. In this study, we resolve this by showing that myogenesis is controlled by opposing NF-κB signaling pathways. We find that myogenesis is enhanced in MyoD-expressing fibroblasts deficient in classical pathway components RelA/p65, inhibitor of κB kinase β (IKKβ), or IKKγ. Similar increases occur in myoblasts lacking RelA/p65 or IKKβ, and muscles from RelA/p65 or IKKβ mutant mice also contain higher fiber numbers. Moreover, we show that during differentiation, classical NF-κB signaling decreases, whereas the induction of alternative members IKKα, RelB, and p52 occurs late in myogenesis. Myotube formation does not require alternative signaling, but it is important for myotube maintenance in response to metabolic stress. Furthermore, overexpression or knockdown of IKKα regulates mitochondrial content and function, suggesting that alternative signaling stimulates mitochondrial biogenesis. Together, these data reveal a unique IKK/NF-κB signaling switch that functions to both inhibit differentiation and promote myotube homeostasis

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3 ubiquitin ligase HUWE1 as a key inducing factor in AMBRA1-mediated mitophagy, a process that takes place independently of the main mitophagy receptors. Furthermore, we show that mitophagy function of AMBRA1 is post-translationally controlled, upon HUWE1 activity, by a positive phosphorylation on its serine 1014. This modification is mediated by the IKKα kinase and induces structural changes in AMBRA1, thus promoting its interaction with LC3/GABARAP (mATG8) proteins and its mitophagic activity. Altogether, these results demonstrate that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells