Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study

<p>Abstract</p> <p>Background</p> <p>Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women.</p> <p>Methods</p> <p>Seventy-nine healthy sedentary post-menopausal women aged 58-78 years participated in this study. Subjects were randomized to one of 4 groups: exercise + supplement (E+S, n = 21), exercise (E, n = 20), supplement (S, n = 20), and control (Con, n = 18) groups. The subjects in the E+S and E groups performed aerobic exercise training (walking and jogging) up to 65% of HR_max, three times a week for 24 weeks. Subjects in the E+S and S groups consumed 1000 mg/d N-3 for 24 weeks. The lumbar spine (L₂-L₄) and femoral neck BMD, serum tumor necrosis factor (TNF) α, interleukin (IL) 6, prostaglandin (PG) E₂, estrogen, osteocalcin, 1, 25-dihydroxyvitamin D₃(1, 25 Vit D), C-telopeptide (CTX), parathyroid hormone (PTH) and calcitonin (CT) were measured at baseline, the end of week 12 and 24.</p> <p>Results</p> <p>Serum estrogen, osteocalcin, 1, 25 Vit D, CT, L₂-L₄and femoral neck BMD measures increased (<it>P </it>< 0.05) and the serum CTX, PTH, TNF-α, IL-6, and PGE₂decreased (<it>P </it>< 0.05) in E + S group after the 24 wk intervention but not in the E or S intervention groups. L₂-L₄and femoral neck BMD, estrogen, osteocalcin, and CT were negatively (<it>P </it>< 0.05) correlated with TNF-α and PGE₂. PTH and CT were correlated positively and negatively with IL-6, respectively (<it>P </it>< 0.05).</p> <p>Conclusions</p> <p>The present study demonstrates that long-term aerobic exercise training plus N-3 supplementation have a synergistic effect in attenuating inflammation and augmenting BMD in post-menopausal osteoporosis.</p

Effect of High Intensity Interval Training and Honey Consumption on some Inflammatory Indices in Sedentary Subjects

Background: The sedentary lifestyle has been introduced as one of the main causes of disease and a predictor of morbidity and mortality. Inflammation is an essential contributor to the pathogenesis of diseases. The aim of the present study was to investigate the effect of high-intensity interval training and honey consumption on IL-6, IL-12 and TNF-a levels in sedentary individuals. Methods: Thirty-eight young, healthy and inactive men were assigned to one of the following interventions: Exercise+placebo (EP), Exercise+Supplement (ES), Supplement (S) and Placebo (P). Subjects in the exercise groups underwent a supervised HIIT program over 8 weeks. Exercise at each session comprised 2 min high intensity training with the intensity of 80-90% of heart rate max interspersed by low-intensity intervals of walking for 1 minute. Throughout the study, the subjects in supplement groups received 5 cc/kg body mass of 13% honey dissolved in plain water within 30-60 min before each exercise session. The subjects in placebo groups were administered with an equal volume of water solution with 5 gr sucrose. Before and 72h after the experimental period blood samples were collected to assess plasma levels of IL-6, IL-12, and TNF-a. Results: We observed that IL-6 levels significantly decreased in ES and E groups from pretest to posttest and there was a significant difference between the ES and control groups (Pvalue=0.023). However, no significant changes were observed for IL-12 and TNF-a (Pvalue&gt; 0.05). Conclusions: HIIT program along with honey consumption over 8 weeks could have favorable effects on inflammatory indices such as IL-6 in subjects with sedentary life-style. Keywords: HIIT; honey; inflammation; IL-6; TNF-α; IL-12

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems. The respiratory system is a place of inappropriate activation of the immune system in people with multiple sclerosis (MS), and this may cause damage to the lung and worsen both MS and infections.The concerns for patients with multiple sclerosis are because of an enhance risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MS patients pose challenges in this pandemic situation, because of the regulatory defect of autoreactivity of the immune system and neurological and respiratory tract symptoms. In this review, we first indicate respiratory issues associated with both diseases. Then, the main mechanisms inducing lung damages and also impairing the respiratory muscles in individuals with both diseases is discussed. At the end, the leading role of physical exercise on mitigating respiratory issues inducing mechanisms is meticulously evaluated. Keywords: COVID-19; Exercise training; Immune system; Multiple sclerosis; Renin–angiotensin system; Respiratory system

The Effects of Combined Aquatic Exercise on Physical Performance and Metabolic Indices in Overweight Healthy Older Adults

International Journal of Exercise Science 16(4): 1499-1513, 2023. Addressing overweight and obesity to promote healthy aging is essential. Exercise is an outstanding approach to manage metabolic and physical dysfunction. Aquatic exercise has been recommended for older individuals due to reduced weight pressure on joints. The aim of this study was to determine the effects of twenty-eight weeks of combined aquatic exercise (aerobic and resistance) in overweight healthy older individuals. Thirty-two subjects of both genders with mean age of 72.06 ± 5.8 years were randomly assigned into two groups: an aquatic exercise group (EG; n = 19) and a control group (CG; n = 13). Body composition, anthropometric measurements, blood pressure, lipid profile, fasting glucose, insulin, and leptin were assessed before and after the training program. The lipid profile, fasting glucose, leptin, insulin, and insulin resistance did not change between and within groups. The lipid profile worsened in the CG. Reduction in body fat mass, waist and leg circumferences, along with body mass gain in the aquatic exercise group was observed (p ≤ 0.05). Systolic and diastolic blood pressure significantly improved in the exercise group (P = 0.003, P = 0.001). Significant differences were found in aerobic endurance (P = 0.008) and lower body flexibility (P = 0.049) of the aquatic exercise group compared with the control group. Also, upper body flexibility (P = 0.001, P = 0.020), lower and upper body strength (P = 0.001, P = 0.031), and handgrip (P = 0.001, P = 0.006), showed significant differences within the exercise group. Aquatic exercise may have a positive impact on the overweight aging population\u27s metabolic and cardiovascular parameters, based on the observed improvements in blood pressure and body composition

Multimodal benefits of exercise in patients with multiple sclerosis and COVID-19

Multiple sclerosis (MS) is a demyelinating disease characterized by plaque formation and neuroinflammation. The plaques can present in various locations, causing a variety of clinical symptoms in patients with MS. Coronavirus disease-2019 (COVID-19) is also associated with systemic inflammation and a cytokine storm which can cause plaque formation in several areas of the brain. These concurring events could exacerbate the disease burden of MS. We review the neuro-invasive properties of SARS-CoV-2 and the possible pathways for the entry of the virus into the central nervous system (CNS). Complications due to this viral infection are similar to those occurring in patients with MS. Conditions related to MS which make patients more susceptible to viral infection include inflammatory status, blood-brain barrier (BBB) permeability, function of CNS cells, and plaque formation. There are also psychoneurological and mood disorders associated with both MS and COVID-19 infections. Finally, we discuss the effects of exercise on peripheral and central inflammation, BBB integrity, glia and neural cells, and remyelination. We conclude that moderate exercise training prior or after infection with SARS-CoV-2 can produce health benefits in patients with MS patients, including reduced mortality and improved physical and mental health of patients with MS.9513-E3E4-C5C9 | Sílvia Fernanda Rocha RodriguesN/

The effects of TRX suspension training on sarcopenic biomarkers and functional abilities in elderlies with sarcopenia: a controlled clinical trial

Abstract Background Sarcopenia is an age-related progressive loss of muscle mass and strength that can be modulated by resistance training. This study aimed to investigate the effects of TRX Suspension Training (TST) on serum levels of neuromuscular and growth factors and functional indices in elderly men with sarcopenia, an age-related condition characterized by progressive muscle mass and strength loss. Methods Nineteen sarcopenic elderly men (age = 74.87 ± 4.58 years) were randomly assigned into two groups, the TST group (n = 10) and the control group (n = 9). Serum concentrations of regulatory muscle markers, anthropometric and body composition indices, and functional tests were evaluated at baseline and after 8 weeks. The training protocol consisted of eight weeks of TRX exercises, with three weekly sessions. Results After 8 weeks of training, growth factors such as Follistatin (FST) (P = 0.001), 22 kDa C-terminal agrin fragment (CAF) (P = 0.031), and growth differentiation factor 15 (GDF15) (P = 0.049) increased significantly in the training group in comparison to the control group and Myostatin (MSTN) (P = 0.002) had a significant decrease. However, there was no significant difference in ASMM/m2 (P = 0.527), SMM/m2 (P = 0.621), or Body fat mass (P = 0.433) within or between groups. In addition, the TRX Suspension Training had a significant effect on the functional tests and improved gait speed (P = 0.037), chair stand (P = 0.016), and TUG (P = 0.016) as well as Handgrip strength (P = 0.035). Conclusion Our findings highlight the efficacy of TRX Suspension Training in enhancing the serum levels of muscle growth factors and functional capacities among elderly individuals with sarcopenia. Therefore, considering the ongoing COVID-19 pandemic, this protocol can prove beneficial for this demographic group. Trial registry Iranian Registry of Clinical Trials identifier: IRCT20230727058944N1, prospectively registered 20-09-2023, https://en.irct.ir/trial/7163

Effect of olive oil on IL-6, TNF-α and cortisol hormone levels in active girls after one session of an exhaustive exercise: a brief report

Background: The aim of this research was to determine the effect of olive oil on interleukin 6 (IL-6), Tumor necrosis factor a (TNF-a) and cortisol hormone in response to exhaustive exercise in active girls.Methods: Twenty four healthy girls aged 21-27 years participated in this study. The subjects were randomly assigned to supplement (n=12) and control (n=12) groups. Supplemented group was fed with olive oil for one week. Blood samples were taken in a week before of exercise test, before exercise, immediately and 1 hour after the end of the exercise.Results: There was a significant increase in the level of cortisol, IL-6 and TNF-α in the supplement and control groups in compared with a week before of exercise test and before exercise test (P≤0.05). There was no significant difference in cortisol levels between the two groups (P≥0.05), but there was a significant difference between the levels of TNF-α and IL-6 in immediately and one hour after the end of exercise (P≤0.05). These markers were lower in the supplement group.Conclusion: Our results show olive oil prevent from increasing inflammatory markers in active girls during exhaustive exercise

Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model

Abstract One of the important concerns in the field of exercise immunology is determining the appropriate intensity and duration of exercise to prevent suppression of the immune system. Adopting a reliable approach to predict the number of white blood cells (WBCs) during exercise can help to identify the appropriate intensity and duration. Therefore, this study was designed to predict leukocyte levels during exercise with the application of a machine-learning model. We used a random forest (RF) model to predict the number of lymphocytes (LYMPH), neutrophils (NEU), monocytes (MON), eosinophils, basophils, and WBC. Intensity and duration of exercise, WBCs values before exercise training, body mass index (BMI), and maximal aerobic capacity (VO2 max) were used as inputs and WBCs values after exercise training were assessed as outputs of the RF model. In this study, the data was collected from 200 eligible people and K-fold cross-validation was used to train and test the model. Finally, model efficiency was assessed using standard statistics (root mean square error (RMSE), mean absolute error (MAE), relative absolute error (RAE), root relative square error (RRSE), coefficient of determination (R2), and Nash–Sutcliffe efficiency coefficient (NSE)). Our findings revealed that the RF model performed well for predicting the number of WBC with RMSE = 0.94, MAE = 0.76, RAE = 48.54, RRSE = 48.17, NSE = 0.76, and R2 = 0.77. Furthermore, the results showed that intensity and duration of exercise are more effective parameters than BMI and VO2 max to predict the number of LYMPH, NEU, MON, and WBC during exercise. Totally, this study developed a novel approach based on the RF model using the relevant and accessible variables to predict WBCs during exercise. The proposed method can be applied as a promising and cost-effective tool for determining the correct intensity and duration of exercise in healthy people according to the body’s immune system response