New Opportunities for the Humanities: Professional Polylogue in a Multilingual World Review of the first international scientific and practical conference “Professional polylogue in a multilingual world: language, culture, method” (Moscow, April 6–7, 2023)

This paper presents a review of the first International Scientific and Practical Conference “Professional Polylogue in a Multilingual World: Language, Culture, Method”, which was held at MGIMO University (Moscow, Russia) on April 6–7, 2023. The conference aimed to explore various issues related to linguistics, foreign language teaching, and socio-cultural factors in modern language education. The event brought together over 300 specialists who participated as speakers and active listeners in seven sections, three online discussion panels, a round table, and a student section “Potential”. Discussions included significant aspects of foreign language learning, trends and stages in foreign language teaching methods, the formation of professional identity in a multilingual world, and the cultural aspect of learning and self-development of both students and teachers

A clinical case of a total therapeutic hypothermia for the newborn

Hypoxic-ischemic encephalopathy (HIE) is one of the most actual problems of рediatrics because of the high mortality and disability of children with this pathology. The most promising technique with a high degree of conclusiveness, that is able to reduce the negative effects of HIE, is considered a therapeutic hypothermia (ТH). In this article we consider a clinical case of low-tech total ТH carried out of newborn with severe HIE. The application of this approach stimulated early recovery of spontaneous breathing, relief of spasms, and also had a favorable impact on the development of the neurological status of the child.Гипоксически-ишемическая энцефалопатия (ГИЭ) является одной из самых актуальных проблем педиатрии из-за высокой летальности и инвалидизации детей с данной патологией. Наиболее перспективной методикой, имеющей высокую степень доказательности, способной негативные последствия снизить ГИЭ, считается лечебная гипотермия (ЛГ). В данной работе рассматривается клинический случай проведенной низкотехнологичной общей ЛГ новорожденному с тяжелой ГИЭ. Своевременное проведение общей ЛГ способствовало раннему восстановлению самостоятельного дыхания, купированию судорог, а также оказало благоприятное воздействие на становление неврологического статуса ребенка

Leucine-glycine and carnosine dipeptides prevent diabetes induced by multiple low-dose streptozotocin in experimental model of adult mice

Aims/Introduction Peptides are considered as quasi‐hormones and effective molecules for regulation of the cells function and metabolic disorders prevention. Di‐ and tripeptides with the ability to gastrointestinal absorption have been proposed to prevent diabetes progression. Materials and Methods Small peptides with different sequences of specific amino acids were synthesized based on a solid phase peptide synthesis (SPPS) protocol as well as carnosine (A) and glutathione (B) were examined for the prevention of diabetes induced by multiple low‐dose of streptozotocin (MLDS) in mice. Results The peptides A, Leu‐Gly (D) and Pro‐Pro (F) exhibited a preventive effects on blood glucose elevation and impairment of the signaling and performance of beta cells. The beta cells function assessed by immunofluorescence and blood glucose level in mice exposed to diabetes treated by the peptides A and D was similar to the normal mice. The peptide D prevented from body weight loss caused by diabetes induction. The use of D and A peptides dramatically prevents the incidence of disruption in beta cells signaling by maintaining the natural balance of intracellular Akt‐2 and cAMP. Conclusions The results proved that peptide D (Leu‐Gly) named Hannaneh inhibits the body weight loss caused by diabetes induction. The Hannaneh and carnosine dipeptides with preservation of normal beta cell signalling and anti DPP‐4 activity were prevented from increasing the blood glucose in mice at risk of diabetes. These dipeptides may be regarded as the pharmaceutical agents for the prevention of diabetes

Нейрорадиологические и патоморфологические особенности опухолей, ассоциированных с эпилепсией

Brain tumors are the second most common etiology in pediatric patients with focal seizures undergoing surgery for drug-resistant epilepsy. These neoplasms have a number of distinctive features from those found in adult patients, one of which is a wide polymorphism of structural architectonics during neuroradiological examination. Given the tremendous biological stability of these tumors, not in all cases of pre-surgical examination it is possible to verify the presence of a neoplastic process in the structure of the epileptogenic substrate using routine neuroimaging methods. In some complex diagnostic cases, a multimodal imaging approach and in-depth complex examination are required for reliable diagnosis and success of the results of epileptic surgery.Опухоли головного мозга представляют собой вторую по частоте этиологию у пациентов детского возраста с фокальными приступами, прошедших процедуру хирургического вмешательство по поводу фармакорезистентной эпилепсии. Эти новообразования имеют ряд отличительных особенностей от обнаруживаемых у взрослых пациентов, одной из которых является широкий полиморфизм структурной архитектоники при проведении нейрорадиологического обследования. Учитывая потрясающую биологическую стабильность этих опухолей, не во всех случаях проведения прехирургического обследования удается верифицировать наличие неопластического процесса в структуре эпилептогенного субстрата рутинными методами нейровизуализации. В некоторых сложных диагностических случаях требуется мультимодальный поход к визуализации и углубленное комплексное обследование для достоверной диагностики и успешности результатов эпилептической хирургии

Спектр мутаций BRCA1/2 у пациенток армянского происхождения с раком молочной железы и яичника

The aim of the study was to compare the spectra of pathogenic BRCA1 and BRCA2 variants in patients with hereditary breast cancer (BC) and ovarian cancer (OC) from two groups of ethnic Armenians: Yerevan and cities of southern Russia.Material and Methods. 106 BC patients from the V.A. Fanardjian National Centre of Oncology (Yerevan, Republic of Armenia) and 117 BC and OC patients of Armenian origin who were referred to the Petrov National Medical Centre of Oncology (St. Petersburg, Russia) from several cancer centers of Russia (Krasnodar, Sochi, Pyatigorsk) were included into the study. The coding sequences of BRCA1 and BRCA2 genes were analyzed by the method of targeted high-throughput sequencing.Results. Pathogenic variants of BCRA1 and BCRA2 genes were detected in 16/106 (BRCA1: n=9, BRCA2: n=7; 15%) BC patients from Yerevan. The only recurrent mutation was the BRCA1 nonsense variant c.5444G>A [W1815X], accounting for 44% of all pathogenic alleles identified. In patients of Armenian origin from Russia, pathogenic BRCA1/2 variants were detected in 16/117 (14%) individuals (BRCA1: n=6, BRCA2: n=10). The proportion of samples with mutations was 13% in the group of BC patients and 19% in the group of OC patients. 75% of pathogenic alleles were represented by five recurrent mutations: BRCA1 c.2649_2650insGGCA, BRCA2 c.2808_2808_2811delACAA, BRCA1 c.4065_4068delTCAA, BRCA2 c.9027delT and BRCA2 c.8437G>T [G2813X]. The independent origin of the pathogenic BRCA2 c.2808_2808_2811delACAA variant in Armenian and non-Armenian patients was shown.Conclusion. A significant difference in the spectrum of BRCA1/2 mutations between Armenian patients from Yerevan and patients from southern regions of Russia was found. This should be taken into account when developing diagnostic programs.Цель исследования – сравнить спектры патогенных вариантов BRCA1 и BRCA2 у пациенток с наследственными формами рака молочной железы (РМЖ) и рака яичников (РЯ) – представительниц двух групп этнических армян: из Еревана и городов юга России.Материал и методы. В исследование включено 106 больных РМЖ из Национального центра онкологии им. В.А. Фанарджяна (Ереван, Республика Армения) и 117 пациенток с РМЖ и РЯ армянского происхождения, которые были направлены в НМИЦ онкологии им. Н.Н. Петрова (Санкт-Петербург) из нескольких онкологических диспансеров России (Краснодар, Сочи, Пятигорск). Анализ кодирующих последовательностей генов BRCA1 и BRCA2 выполнялся методом таргетного высокопроизводительного секвенирования.Результаты. В группе больных РМЖ из Еревана выявлено 16/106 (15 %) носительниц патогенных вариантов BRCA1/2 (BRCA1: n=9, BRCA2: n=7). Единственной повторяющейся мутацией оказался нонсенс-вариант BRCA1 c.5444G>A [W1815X], составляющий 44 % всех выявленных патогенных аллелей. У пациенток армянского происхождения из России патогенные варианты BRCA1/2 были обнаружены у 16/117 (14 %) человек (BRCA1: n=6, BRCA2: n=10). В группе пациенток с РМЖ доля образцов с мутациями составила 13 %, а у больных РЯ – 19 %. 75 % патогенных аллелей были представлены пятью повторяющимися мутациями: BRCA1 c.2649_2650insGGCA, BRCA2 c.2808_2811delACAA, BRCA1 c.4065_4068delTCAA, BRCA2 c.9027delT и BRCA2 c.8437G>T [G2813X]. Показано независимое происхождение патогенного варианта BRCA2 c.2808_2811delACAA у пациенток армянского и неармянского происхождения.Заключение. Спектр мутаций BRCA1/2 у пациенток армянского происхождения из Еревана и южных регионов России имеет существенные различия, что следует учитывать при разработке диагностических программ

Output effect of a quadrature receiver with an input band-pass filter at reception of a phase-keyed wideband signal

An output effect of a quadrature correlation receiver with an input band-pass filter at reception of a phase-keyed wideband signal is considered. Analytical expressions for output effect of a receiver proportional to the absolute value of a complex envelope of a cross-correlation function for received and reference signals are obtained. Dependences of cross-correlation function absolute value on a time delay, frequency mismatch of a received and reference signals, and passband width of input filter are analyzed. It is shown, that cross-correlation function’s maximum is reached in case of non-zero time delay of a received signal when there is no frequency mismatch between input and reference signals. The time delay value corresponding to cross-correlation function’s maximum depends on passband width of input filter

Phase-Shift keyed wideband signal against noises detection by quadrature receiver with input band-pass filter

In this paper we consider wideband signal against noise receiving by quadrature correlation receiver with input band-pass filter. We obtain analytical expressions of detection characteristics. We analyzed dependences of correct receiving on delay time, signal-to-noise ratio and input filter bandwidth. It is shown, that maximal probability of signal detection is obtained in case of non-zero delay time of received signal, which depends on filter bandwidth