A prospective study of demographic profile, risk factors and pregnancy outcome in Hepatitis B and Hepatitis C virus positive pregnant women in a tertiary care centre

Background: Viral hepatitis is the most common liver disease in pregnancy and is also the most common cause of jaundice in pregnancy in tropical countries. Risk factors for transmission are intravenous drug abuse, surgical and dental procedures done without adequate sterilization of instruments, sexual route etc. Early diagnosis and management can prevent maternal and fetal complications. This study was done to evaluate the frequency, risk factors and pregnancy outcome in hepatitis B virus (HBV) and hepatitis C virus (HCV) positive antenatal women.Methods: This case control study was conducted in Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India from January 2017 to June 2018 on total 2511 pregnant women. The serum samples were checked for presence of hepatitis B surface antigen (HBsAg) and presence of IgG antibodies to HCV. Analysis of sociodemographic profile, risk factors and pregnancy outcome were done in all HBV and HCV positive women.Results: Out of 2511 pregnant women, 292 were tested positive for hepatitis. Maximum number of women were in the age group of 21-30 years. Most of the seropositive women were multipara. Frequency of positivity was maximum for HCV (67.1%). The risk factors for transmission in study population were intravenous drug abuse, blood transfusion, history of surgery and tattooing.Conclusions: Hepatitis infection rate is increasing. Universal screening for HBV and HCV can be recommended in pregnant women in developing countries. Education and awareness of public and health care workers can reduce the risk of transmission.

Digital Education for Health Professions on Smoking Cessation Management:Systematic Review by the Digital Health Education Collaboration

BACKGROUND: Tobacco smoking, one of the leading causes of preventable death and disease, is associated with 7 million deaths every year. This is estimated to rise to more than 8 million deaths per year by 2030, with 80% occurring in low- and middle-income countries. Digital education, teaching, and learning using digital technologies have the potential to increase educational opportunities, supplement teaching activities, and decrease distance barriers in health professions education. OBJECTIVE: The primary objective of this systematic review was to evaluate the effectiveness of digital education compared with various controls in improving learners' knowledge, skills, attitudes, and satisfaction to deliver smoking cessation therapy. The secondary objectives were to assess patient-related outcomes, change in health professionals' practice or behavior, self-efficacy or self-rated competence of health professionals in delivering smoking cessation therapy, and cost-effectiveness of the interventions. METHODS: We searched 7 electronic databases and 2 trial registers for randomized controlled trials published between January 1990 and August 2017. We used gold standard Cochrane methods to select and extract data and appraise eligible studies. RESULTS: A total of 11 studies (number of participants, n=2684) were included in the review. All studies found that digital education was at least as effective as traditional or usual learning. There was some suggestion that blended education results in similar or greater improvements in knowledge (standardized mean difference, SMD=0.19, 95% CI -0.35 to 0.72), skill (SMD=0.58, 95% CI 0.08-1.08), and satisfaction (SMD=0.62, 95% CI 0.12-1.12) compared with digital education or usual learning alone. There was also some evidence for improved attitude (SMD=0.45, 95% CI 0.18-0.72) following digital education compared with usual learning. Only 1 study reported patient outcomes and the setup cost of blended education but did not compare outcomes among groups. There were insufficient data to investigate what components of the digital education interventions were associated with the greatest improvements in learning outcomes. CONCLUSIONS: The evidence suggests that digital education is at least as effective as usual learning in improving health professionals' knowledge and skill for delivering smoking cessation therapy. However, limitations in the evidence base mean that these conclusions should be interpreted with some caution. TRIAL REGISTRATION: PROSPERO CRD42016046815; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=46815

Clinical and microbiological profile of urinary tract infection in children less than twelve years of the age and their antibiotics resistant pattern at a Tertiary Care Hospital in Kanpur, India

Background: Urinary tract infection (UTI) is the most common bacterial infection which is seen in childhood population, which starts from the calyces of the kidney to the urethra. It is an important cause of morbidity and mortality in children mostly in the first 2 years of life. The Gram negative enteric bacilli, especially Escherichia coli and Klebsiella spp. the dominant pathogens. The objective of the study was to analyze the causative microorganism and their Antibiotic Resistance Pattern in UTI in childhood population between 0-12years of the age. Methods: This one year prospective and observational study was conducted in the Department of Microbiology; Rama Medical College Hospital & Research Centre Kanpur, Uttar Pradesh, India, on 100 pediatric patients (aged 0-12 years). All the pediatric age group (0-12 years) with suspected UTI and, whose urine culture showed one or two pathogen with colony counts greater than or equal to 105 colony forming units (CFU)/ml was included for the study. Clinical data was obtained from OPD and IPD Patients. Antimicrobial susceptibility was done for positive urine culture by Kirby-Bauer disk diffusion method. The data was expressed in terms of frequency and percentage

Clinical and Microbiological Profile of Urinary Tract Infection in Children Less Than Twelve Years of the Age and Their Antibiotics Resistant Pattern at A Tertiary Care Hospital in Kanpur, India

Background: Urinary tract infection (UTI) is the most common bacterial infection which is seen in childhood population, which starts from the calyces of the kidney to the urethra. It is an important cause of morbidity and mortality in children mostly in the first 2 years of life. The Gram negative enteric bacilli, especially Escherichia coli and Klebsiella spp. the dominant pathogens. The objective of the study was to analyze the causative microorganism and their Antibiotic Resistance Pattern in UTI in childhood population between 0-12years of the age. Methods: This one year prospective and observational study was conducted in the Department of Microbiology; Rama Medical College Hospital & Research Centre Kanpur, Uttar Pradesh, India, on 100 pediatric patients (aged 0-12 years). All the pediatric age group (0-12 years) with suspected UTI and, whose urine culture showed one or two pathogen with colony counts greater than or equal to 105 colony forming units (CFU)/ml was included for the study. Clinical data was obtained from OPD and IPD Patients. Antimicrobial susceptibility was done for positive urine culture by Kirby-Bauer disk diffusion method. The data was expressed in terms of frequency and percentage

Additional file 3: Table S3. of Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action

Quality ratings for included systematic reviews of melatonin for health. (DOCX 254 kb

Additional file 2: Table S2. of Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action

Summary of studies on the effects of endogenous melatonin on health outcomes (N = 75). (DOCX 111 kb

Additional file 5: Table S5. of Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action

Summary of the adverse effects of MLT reported in the studies included (N = 11). (DOCX 24 kb