4,660 research outputs found
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients
Purpose: Methotrexate administration is associated with
frequent adverse neurological events during treatment for
childhood acute lymphoblastic leukemia. Here, we present
evidence to support the role of common drug interactions
and low vitamin B12 levels in potentiating methotrexate
neurotoxicity.
Methods: We review the published evidence and highlight
key potential drug interactions as well as present clinical
evidence of severe methotrexate neurotoxicity in conjunction
with nitrous oxide anesthesia and measurements of
vitamin B12 levels among pediatric leukemia patients during
therapy.
Results: We describe a very plausible mechanism for
methotrexate neurotoxicity in pediatric leukemia patients
involving reduction in methionine and consequential disruption
of myelin production. We provide evidence that a
number of commonly prescribed drugs in pediatric leukemia
management interact with the same folate biosynthetic
pathways and/or reduce functional vitamin B12 levels and
hence are likely to increase the toxicity of methotrexate in
these patients. We also present a brief case study supporting
out hypothesis that nitrous oxide contributes to methotrexate
neurotoxicity and a nutritional study, showing that
patients.
Conclusions: Use of nitrous oxide in pediatric leukemia
patients at the same time as methotrexate use should be
avoided especially as many suitable alternative anesthetic
agents exist. Clinicians should consider monitoring levels
of vitamin B12 in patients suspected of having methotrexate-
induced neurotoxic effects
Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect
No abstract available
Note: Autonomous Pulsed Power Generator Based on Transverse Shock Wave Depolarization of Ferroelectric Ceramics
Autonomous pulsed generators utilizing transverse shock wave depolarization (shock front propagates across the polarization vector P0) of Pb(Zr0.52Ti0.48)O3 poled piezoelectric ceramics were designed, constructed, and experimentally tested. It was demonstrated that generators having total volume of 50 cm3 were capable of producing the output voltage pulses with amplitude up to 43 kV with pulse duration 4 µs. A comparison of high-voltage operation of transverse and longitudinal shock wave ferroelectric generators is given
Coupled Particle Transport and Pattern Formation in a Nonlinear Leaky-Box Model
Effects of particle-particle coupling on particle characteristics in nonlinear leaky-box type descriptions of the acceleration and transport of energetic particles in space plasmas are examined in the framework of a simple two-particle model based on the Fokker-Planck equation in momentum space. In this model, the two particles are assumed coupled via a common nonlinear source term. In analogy with a prototypical mathematical system of diffusion-driven instability, this work demonstrates that steady-state patterns with strong dependence on the magnetic turbulence but a rather weak one on the coupled particles attributes can emerge in solutions of a nonlinearly coupled leaky-box model. The insight gained from this simple model may be of wider use and significance to nonlinearly coupled leaky-box type descriptions in general
Rotons and Quantum Evaporation from Superfluid 4He
The probability of evaporation induced by and rotons at the
surface of superfluid helium is calculated using time dependent density
functional theory. We consider excitation energies and incident angles such
that phonons do not take part in the scattering process. We predict sizable
evaporation rates, which originate entirely from quantum effects. Results for
the atomic reflectivity and for the probability of the roton change-mode
reflection are also presented.Comment: 11 pages, REVTEX, 3 figures available upon request or at
http://anubis.science.unitn.it/~dalfovo/papers/papers.htm
De Litteris
This book is drawn from a series of annual faculty lectures at Connecticut College. The contents are Some Philosophical Remarks About Poetry, Robert W. Jordan Linguistics and Rhetoric, Eugene P. Cognon Literary Problems in Interpreting Paul\u27s Letters, Gordon P. Wiles Iris Sacred and Profane: the Philosopher as Novelist, Susan M. Woody Toward an American Epic: Four Poets, James R. Baird 1100 A.D.: A Crisis for Us?, F. Edward Cranz Of Messages and Messengers, Marijan Despalotovichttps://digitalcommons.conncoll.edu/ccbooks/1006/thumbnail.jp
Pd/Cr Gates for a MIS Type Hydrogen Sensor
Instead of the pure Pd gates in MIS type hydrogen sensor, Pd-Cr alloy gates with different composition and structure were used to improve the sensors performance. The use of Pd-Cr alloy not only extended the dynamic range from 100 ppm to 50,000 ppm of hydrogen, but also showed quick response. The dynamic range and sensitivity were related to the nature of metal outer surface and the metal/insulator interface respectively
Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer
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