8,813 research outputs found
A Survey of Ring Baffle Damping in Cylindrical Tanks
Survey of Miles method for determination of damping by ring baffles in cylindrical tank
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ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury.
The complex molecular microenvironment of the wound bed regulates the duration and degree of inflammation in the wound repair process, while its dysregulation leads to impaired healing. Understanding factors controlling this response provides therapeutic targets for inflammatory disease. Esophageal cancer-related gene 4 (ECRG4) is a candidate chemokine that is highly expressed on leukocytes. We used ECRG4 knockout (KO) mice to establish that the absence of ECRG4 leads to defective neutrophil recruitment with a delay in wound healing. An in vitro human promyelocyte model identified an ECRG4-mediated suppression of the hyaluronic acid receptor, CD44, a key receptor mediating inflammation resolution. In ECRG4 KO mouse leukocytes, there was an increase in CD44 expression, consistent with a model in which ECRG4 negatively regulates CD44 levels. Therefore, we propose a previously unidentified mechanism in which ECRG4 regulates early neutrophil recruitment and subsequent CD44-mediated resolution of inflammation
The Impact of Rising Ocean Acidification Levels on Fish Migration
Ocean acidification, a direct consequence of increased carbon dioxide (CO2)emissions, has emerged as a critical area of concern within the scientific community.The world's oceans absorb approximately one-third of human-caused CO2 emissions,leading to chemical reactions that reduce seawater pH, carbonate ion concentration,and saturation states of biologically important calcium carbonate minerals. Thisprocess, known as ocean acidification, has far-reaching implications for marineecosystems, particularly for marine organisms such as fish, whose migratory patternsare integral to the health and function of these ecosystems.
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The role of hydrological transience in peatland pattern formation
The sloping flanks of peatlands are commonly patterned with non-random, contour-parallel stripes of distinct microhabitats such as hummocks, lawns and hollows. Patterning seems to be governed by feedbacks among peatland hydrological processes, plant micro-succession, plant litter production and peat decomposition. An improved understanding of peatland patterning may provide important insights into broader aspects of the long-term development of peatlands and their likely response to future climate change
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