19,578 research outputs found
Asymptotic properties of eigenmatrices of a large sample covariance matrix
Let where is a matrix
with i.i.d. complex standardized entries having finite fourth moments. Let
in which
and where
is the Mar\v{c}enko--Pastur law with parameter ; which
converges to a positive constant as , and and are unit vectors in ,
having indices and , ranging in a compact subset
of a finite-dimensional Euclidean space. In this paper, we prove that the
sequence converges weakly to a
-dimensional Gaussian process. This result provides further evidence in
support of the conjecture that the distribution of the eigenmatrix of is
asymptotically close to that of a Haar-distributed unitary matrix.Comment: Published in at http://dx.doi.org/10.1214/10-AAP748 the Annals of
Applied Probability (http://www.imstat.org/aap/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
BACKGROUND: Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood. METHODS: BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis. The virus-infected mice were treated with the CC chemokine antagonist Met-RANTES or anti-RANTES mAb to determine the role of RANTES in affecting TBEV-induced neurological disease. The underlying signaling mechanisms were delineated using RANTES promoter luciferase reporter assay, siRNA-mediated knockdown, and pharmacological inhibitors in human brain-derived cell culture models. RESULTS: In a mouse model, pathological features including marked inflammatory cell infiltrates were observed in brain sections, which correlated with a robust up-regulation of RANTES within the brain but not in peripheral tissues and sera. Antagonizing RANTES within CNS extended the survival of mice and reduced accumulation of infiltrating cells in the brain after TBEV infection. Through in vitro studies, we show that virus infection up-regulated RANTES production at both mRNA and protein levels in human brain-derived cell lines and primary progenitor-derived astrocytes. Furthermore, IRF-3 pathway appeared to be essential for TBEV-induced RANTES production. Site mutation of an IRF-3-binding motif abrogated the RANTES promoter activity in virus-infected brain cells. Moreover, IRF-3 was activated upon TBEV infection as evidenced by phosphorylation of TBK1 and IRF-3, while blockade of IRF-3 activation drastically reduced virus-induced RANTES expression. CONCLUSIONS: Our findings together provide insights into the molecular mechanism underlying RANTES production induced by TBEV, highlighting its potential importance in the process of neuroinflammatory responses to TBEV infection
miRNAs-mediated overexpression of Periostin is correlated with poor prognosis and immune infiltration in lung squamous cell carcinoma.
Lung cancer is one of the most common malignancies with a high mortality rate worldwide. POSTN has been shown to be strongly correlated with the poor prognosis of lung cancer patients. However, the function and mechanism of action of POSTN in lung cancer remain unclear. Here, we carried out a pan-cancer analysis to assess the clinical prognostic value of POSTN based on the TCGA, TIMER, Oncomine, Kaplan-Meier, and UALCAN databases. We found that upregulated POSTN can be a promising biomarker to predict the prognosis of patients with lung cancer. High levels of POSTN correlated with immune cell infiltration in lung cancer, especially lung squamous cell carcinoma (LUSC), which was further confirmed based on the results from the TISIDB database. Moreover, the expression analysis, correlation analysis, and survival analysis revealed that POSTN-targeted miRNAs, downregulation of has-miR-144-3p and has-miR-30e-3p, were significantly linked to poor prognosis in patients with LUSC. Taken together, we identified that POSTN can act as a novel biomarker for determining the prognosis related to immune infiltration in patients with LUSC and deserves further research
Existence problem of proton semi-bubble structure in the state of Si
The fully self-consistent Hartree-Fock (HF) plus random phase approximation
(RPA) based on Skyrme-type interaction is used to study the existence problem
of proton semi-bubble structure in the state of Si. The
experimental excitation energy and the B(E2) strength of the state in
Si can be reproduced quite well. The tensor effect is also studied. It
is shown that the tensor interaction has a notable impact on the excitation
energy of the state and a small effect on the B(E2) value. Besides, its
effect on the density distributions in the ground and state of
Si is negligible. Our present results with T36 and T44 show that the
state of Si is mainly caused by proton transiton from orbit to orbit, and the existence of a proton
semi-bubble structure in this state is very unlikely.Comment: 6 pages, 3 figures, 3 table
A Population of Radio-loud Narrow Line Seyfert 1 Galaxies with Blazar-like Properties?
(abridged) We present a comprehensive study of a sample of 23 genuine
radio-loud NLS1 galaxies which have the radio-loudness parameters greater than
100. The radio sources of the sample are ubiquitously compact. A significant
fraction of these objects show interesting radio to X-ray properties that are
unusual to most of the previously known radio-loud NLS1 AGN, but are
reminiscent of blazars. These include flat radio spectra, large amplitude flux
and spectral variability, compact VLBI cores, very high brightness temperatures
derived from variability, enhanced optical emission in excess of the normal
ionising continuum, flat X-ray spectra, and blazar-like SEDs. We interpret them
as evidence for the postulated blazar nature of these very radio-loud NLS1 AGN,
which might possess at least moderately relativistic jets. Intrinsically, some
of the objects have relatively low radio power and would have been classified
as radio-intermediate AGN. The black hole masses are estimated to be within
10^{6-8}Msun, and the inferred Eddington ratios are around unity. The results
imply that radio-loud AGN may be powered by black holes with moderate masses
(10^{6-7}Msun) accreting at high rates. We find that a significant fraction of
the objects, despite having strong emission lines, resemble high-energy peaked
BL Lacs (HBL) in their SED. Given the peculiarities of blazar-like NLS1
galaxies, questions arise as to whether they are plain downsizing extensions of
normal radio-loud AGN, or whether they form a previously unrecognised
population.Comment: Comments: 29 pages, 16 figures, 4 tables, accepted for publication in
Ap
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